147149-98-2

Basic information

• Product Name: 4-Amino-2-trifluoromethylpyridine
• Synonyms: 2-Ctrifluoromethyl/pyridin-4-amine;4-Amino-2-(trifluoromethyl)-pyridine;2-(Trifluoromethyl)pyridin-4-amine;2-CTRIFLUOROMETHYL/PYRIDIN-4-AMINE,98%;2-trifluoromethyl-4-aminopyridine;2-Trifluoromethyl-pyridin-4-ylamine;2-(Trifluoromethyl)pyridin-4-amine (4-Amino-2-trifluoromethylpyridine);4-Pyridinamine, 2-(trifluoromethyl)-
• CAS NO: 147149-98-2
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.12
• Product Categories: Pyridine;Fluorine series
• Mol File: 147149-98-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 230.695 °C at 760 mmHg
• Flash Point: 93.321 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.065mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.62±0.50(Predicted)
• CAS DataBase Reference: 4-Amino-2-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-trifluoromethylpyridine(147149-98-2)
• EPA Substance Registry System: 4-Amino-2-trifluoromethylpyridine(147149-98-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36-43
• Safety Statements: 26-36/37
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 147149-98-2(Hazardous Substances Data)

Usage

Description

4-Amino-2-trifluoromethylpyridine is a chemical compound with the molecular formula C6H5F3N2. It is a pyridine derivative, which is a class of organic compounds characterized by a six-membered aromatic ring with two nitrogen atoms and four carbon atoms. 4-Amino-2-trifluoromethylpyridine is notable for its trifluoromethyl group and amino group, which impart unique chemical properties to the molecule. The specific physical and chemical characteristics of 4-Amino-2-trifluoromethylpyridine, such as its melting point, density, and solubility, can vary depending on factors like temperature and pressure. While its potential applications in chemical synthesis or industrial processes are not fully detailed, it is important to consult a material safety data sheet for more information on its uses and potential hazards.

Uses

Used in Chemical Synthesis:
4-Amino-2-trifluoromethylpyridine is used as a building block in the synthesis of various complex organic molecules. Its unique structure, which includes a trifluoromethyl group and an amino group, allows it to participate in a range of chemical reactions, making it a valuable intermediate in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Industrial Processes:
In the industrial sector, 4-Amino-2-trifluoromethylpyridine may be employed as a catalyst or a reagent in certain chemical processes. Its reactivity and the presence of the trifluoromethyl group can enhance the efficiency of certain reactions, potentially leading to the production of high-value chemicals or materials.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)5-3-4(10)1-2-11-5/h1-3H,(H2,10,11)

Upstream product

• 147149-97-1 ⁽²⁸⁾-4-Nitro-6-trifluoromethylpyridine-N-oxide 
• 131748-14-6 4-chloro-2-trifluoromethylpyridine 
• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 
• 951627-69-3 4-nitro-2-(trifluoromethyl)pyridine 
• 2403-02-3 4-carboxy-2-nitropyridine N-oxide 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 340006-62-4 (Z)-1,1,1-Trifluoro-6-methoxy-hex-5-en-3-yn-2-one 
• 22253-71-0 2-(trifluoro-methyl)pyridine 1-oxide 

Downstream Products

• 871556-34-2 N-[2-(trifluoromethyl)-4-pyridinyl]carbamic acid phenyl ester 
• 1446502-11-9 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol 
• 1036990-42-7 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine 
• 590371-73-6 2-(trifluoromethyl)pyridine-4-iodide 

Relevant articles and documents

A general and versatile synthesis of 2-alkyl-4-aminopyridines

A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield.

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

CXCR3 RECEPTOR ANTAGONISTS

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.