2403-02-3

Upstream product

• 22710-07-2 2,3-dimethylpyridine 1-oxide 
• 497-19-8 sodium carbonate 
• 694-59-7 pyridine N-oxide 
• 504-29-0 2-aminopyridine 

Downstream Products

• 2402-95-1 2-chloropyridine-N-oxide 
• 15009-91-3 2-nitropyridine 
• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 147149-98-2 2-(trifluoromethyl)pyridin-4-amine 
• 504-29-0 2-aminopyridine 
• 195813-55-9 2,6-bis-(2'-methoxyphenyl)pyridine 
• 1403954-98-2 2-(2-methoxy-5-methylphenyl)-6-(2-methoxyphenyl)pyridine 
• 1131-33-5 2-phenylpyridin N-oxide 
• 1403954-96-0 (E)-2-phenyl-6-(prop-1-enyl)pyridine N-oxide 
• 35469-61-5 (E)-2-(α-styryl)pyridine 1-oxide 
• 33421-20-4 2-(2-methylphenyl)pyridine N-oxide 
• 1403954-64-2 2-cyclohexenylpyridine N-oxide 

Relevant academic research and scientific papers

Nanocomposite-based inorganic-organocatalyst Cu(II) complex and SiO2- and Fe3O4 nanoparticles as low-cost and efficient catalysts for aniline and 2-aminopyridine oxidation

Bis-imino Cu(II) complex (CuLAn2), in which the imine ligand (HLAn) acts as a bidentate chelating ligand, was synthesized. The catalytic potential of the inorganic-organocatalyst was studied homogeneously and heterogeneously in the oxidation of aniline and 2-aminopyridine by H2O2 or tBuOOH. Two heterogeneous inorganic-organocatalysts, CuLAn2@Fe3O4 and CuLAn2@SiO2@Fe3O4, were synthesized by the successful immobilization of CuLAn2 on the Fe3O4 surface and the composited Fe3O4 with SiO2, respectively. The heterogeneous structure of those inorganic-organocatalysts was confirmed using Fourier-transform infrared, scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, transmission electron microscopy, and magnetic properties. The adsorption–desorption isotherms revealed respectable adsorption parameters (SBET, Vp, and rp). All catalysts exhibited high potential in the oxidation of aniline (with phenylhydroxylamine as the main product) and good potential in the oxidation of 2-aminopyridine, in the first attempt (with 2-nitropyridine-N-oxide and 2-nitrosopyridine-N-oxide as main products), at room temperature. Acetonitrile was found to be the best solvent compared to ethanol, dimethyl sulfoxide, chloroform, and water. The homogeneous catalyst exhibited reusability for three times. The heterogeneous catalysts, CuLAn2@Fe3O4 and CuLAn2@SiO2@Fe3O4, were active for five and seven times, respectively. A mechanism was proposed within electron and oxygen transfer processes.

A two-step continuous flow synthesis of 4-nitropyridine

4-Nitropyridine, a key intermediate in medicinal products, was successfully prepared from pyridine N-oxide in a two-step -approach. Pyridine N-oxide was nitrated with HNO3 and H2SO4 to give 4-nitropyridine N-oxide, followed by reaction with PCl3 to give the final product. The continuous flow methodology was used to minimise accumulation of the highly energetic and potentially explosive nitration product to enable the safe scale-up of 4-nitropyridine with no 2-nitropyridine by-product. By employing continuous extraction in the nitration step and applying the optimised conditions, a throughput of 0.716 kg 4-nitropyridine product per day from pyridine N-oxide with 83% yield and high selectivity in a continuous flow system was achieved.

Substituted fused pyrazolo compounds

Novel substituted pyrazolo-rings fused to nitrogen containing heterocyclic rings having the following formula STR1 in which at least one of Y, Z or W is N or N-O and the remainder of Y, Z or W is C-R wherein the variables are as defined in the specification; and agriculturally acceptable salts thereof.