149281-42-5Relevant articles and documents
Direct synthesis of β-aminoketones from amides via novel sequential nucleophilic substitution/Michael reaction
Gomtsyan, Arthur
, p. 11 - 13 (2000)
(formula presented) The synthesis of β-aminoketones from amides can be achieved in a process consisting of sequential nucleophilic substitution at the carbonyl group by vinylmagnesium bromide followed by Michael reaction after quench of the first reaction
PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 130; 131, (2018/08/04)
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS. (I)
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia
Hamada, Makoto,Takayama, Tetsuo,Shibata, Tsuyoshi,Hiratate, Akira,Takahashi, Masato,Yashiro, Miyoko,Takayama, Noriko,Okumura-Kitajima, Lisa,Koretsune, Hiroko,Kajiyama, Hiromitsu,Naruse, Takumi,Kato, Sota,Takano, Hiroki,Kakinuma, Hiroyuki
supporting information, p. 1725 - 1730 (2018/04/30)
Prolyl hydroxylase domain-containing protein (PHD) inhibitors are useful as orally administered agents for the treatment of renal anemia. Based on the common structures of known PHD inhibitors, we found novel PHD inhibitor 1 with a 2-[(4-hydroxy-6-oxo-2,3