15284-33-0

Basic information

• Product Name: 1-ethenyl-1H-tetrazol-5-amine
• CAS NO: 15284-33-0
• Molecular Formula: C₃H₅N₅
• Molecular Weight: 111.1053
• Mol File: 15284-33-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 284.7°C at 760 mmHg
• Flash Point: 126°C
• Density: 1.52g/cm³
• Vapor Pressure: 0.00294mmHg at 25°C
• Refractive Index: 1.717
• CAS DataBase Reference: 1-ethenyl-1H-tetrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethenyl-1H-tetrazol-5-amine(15284-33-0)
• EPA Substance Registry System: 1-ethenyl-1H-tetrazol-5-amine(15284-33-0)

Safety Data

• Hazardous Substances Data: 15284-33-0(Hazardous Substances Data)

Usage

General Description

1-ethenyl-1H-tetrazol-5-amine, also known as Edaravone, is a chemical compound with the molecular formula C5H6N4. It is a small molecule that has been developed as a neuroprotective and antioxidant drug. Edaravone has been shown to have beneficial effects in the treatment of acute ischemic stroke and amyotrophic lateral sclerosis. It works by scavenging free radicals and inhibiting lipid peroxidation, thereby protecting brain cells from damage. Additionally, it has been studied for its potential in treating conditions such as Alzheimer's disease and Parkinson's disease. Overall, Edaravone shows promise as a therapeutic agent in the treatment of neurological disorders and as a neuroprotective agent.

Upstream product

• 4418-61-5 5-aminotetrazole 
• 108-05-4 vinyl acetate 
• 106-93-4 ethylene dibromide 
• 15284-31-8 1-(2-chloroethyl)-5-aminotetrazole 

Downstream Products

• 150996-53-5 Pd(1-vinyl-5-aminotetrazole)2Cl₂ 
• 150996-52-4 Ni(1-vinyl-5-aminotetrazole)2Cl₂ 
• 150996-51-3 Cu(1-vinyl-5-aminotetrazole)2Cl₂ 

Relevant articles and documents

Vinyltetrazoles: II. Synthesis of 5-substituted 1(2)-vinyltetrazoles

5-R-Substituted 1(2)-vinyltetrazoles (R = Ar, Alk, CH2=CH, NH2, H) were synthesized by alkylation of 5-R-tetrazoles with 1,2-dibromoethane in the presence of triethylamine in acetonitrile, followed by elimination of triethylamine hydrobromide. Vinylation of dinuclear substrates, such as bis(1H-tetrazol-5-yl)-methane and 1,3-bis(1H-tetrazol-5-yl)benzene, under analogous conditions gave the corresponding N1,N 2′- and N2,N2′-divinyl derivatives.

SYNTHESIS OF FUNCTIONALLY SUBSTITUTED N-VINYLTETRAZOLES

5-Alkyl- and 5-aryl-N-vinyltetrazoles (II) are formed during vinyl exchange between 5-substituted tetrazoles (I) and vinyl acetate in the presence of the copper acetate-boron trifluoride etherate catalytic system.The direction of vinylation depends on steric effects and on the electronic nature of the substituents at position 5 of the tetrazole ring.A series of functionally substituted 2-vinyltetrazoles were obtained by nucleophilic substitution of the chlorine in 2-vinyl-5-chloromethyltetrazole.