153239-91-9

Basic information

• Product Name: 5-Iodo-2-Methylpyridazin-3(2h)-one
• Synonyms: 5-Iodo-2-Methylpyridazin-3(2h)-one;5-iodo-2-methyl-2,3-dihydropyridazin-3-one;5-Iodo-2-methyl-3(2H)-pyridazinone
• CAS NO: 153239-91-9
• Molecular Formula: C₅H₅IN₂O
• Molecular Weight: 236.01047
• Product Categories: CMLLYL
• Mol File: 153239-91-9.mol

Chemical Properties

• Melting Point: 179-180 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 236.3±43.0 °C(Predicted)
• Appearance: /
• Density: 2.07±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.41±0.20(Predicted)
• CAS DataBase Reference: 5-Iodo-2-Methylpyridazin-3(2h)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-2-Methylpyridazin-3(2h)-one(153239-91-9)
• EPA Substance Registry System: 5-Iodo-2-Methylpyridazin-3(2h)-one(153239-91-9)

Safety Data

• Hazardous Substances Data: 153239-91-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Iodo-2-Methylpyridazin-3(2h)-one is utilized as a building block in the synthesis of novel organic compounds that possess potential pharmacological properties. Its unique structure allows for the development of new drugs with specific therapeutic applications.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-Iodo-2-Methylpyridazin-3(2h)-one serves as a valuable component for the exploration and creation of new therapeutic agents. Its incorporation into various chemical entities can lead to the discovery of innovative medications.
Used in Chemical Synthesis:
5-Iodo-2-Methylpyridazin-3(2h)-one is employed as a reagent in chemical synthesis processes. Its presence can facilitate organic transformations, contributing to the development of new chemical compounds with diverse applications.
Used in Laboratory Research:
In laboratory settings, 5-Iodo-2-Methylpyridazin-3(2h)-one is used to support research and development efforts. Its role as a reagent aids in the advancement of scientific understanding and the creation of new chemical entities for various purposes.

Upstream product

• 933-76-6 4,5-dichloro-2-methyl-3(2H)-pyridazinone 
• 74-88-4 methyl iodide 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 

Downstream Products

• 359844-89-6 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-N-pivaloylanilide 
• 359844-90-9 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide 
• 682344-91-8 5-(2-bromophenoxy)-2-methylpyridazin-3(2H)-one 
• 682344-96-3 5-[(2-bromophenyl)amino]-2-methylpyridazin-3(2H)-one 
• 359844-93-2 5-(2-azidophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-91-0 5-(2-aminophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-92-1 5-(2-amino-5-chlorophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-94-3 5-(2-azido-5-chlorophenyl)-2-methylpyridazin-3(2H)-one 
• 1001619-97-1 C₁₄H₁₂N₂O₃ 
• 1346156-08-8 5-(5-chloro-2-triphenylphosphoranylideneaminophenyl)-2-methylpyridazin-3(2H)-one 
• 1346156-10-2 3-methyl-5-phenylamino-pyridazino[4,5-c]quinolin-4(3H)-one 
• 1346156-13-5 5-[2-(1,6-dihydro-1-methyl-6-oxopyridazin-4-yl)-phenylamino]-3-methylpyridazino[4,5-c]-quinolin-4(3H)-one 
• 1346156-11-3 9-chloro-3-methyl-5-phenylamino-pyridazino[4,5-c]quinolin-4(3H)-one 
• 1346156-14-6 5-[2-(1,6-dihydro-1-methyl-6-oxopyridazin-4-yl)-4-chlorophenyl-amino]-9-chloro-3-methyl-pyridazino[4,5-c]quinolin-4(3H)-one 

Relevant articles and documents

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof

Synthesis of 5H-pyridazino[4,5-b]indoles and their benzofurane analogues utilizing an intramolecular Heck-type reaction

The title ring systems were prepared from pyridazin-3(2H)-one precursors in novel, efficient pathways. 2-Methylbenzo[b]furo[2,3-d]pyridazin-1(2H)-one was synthesized via a regioselective nucleophilic substitution reaction of a 2-methyl-4,5-dihalopyridazin-3(2H)-one with phenol followed by an intramolecular Heck-type reaction. The same molecule and its 6-phenyl analogue were also prepared via reaction of 2-methyl-5-iodopyridazin-3(2H)-one or 2-methyl-5-chloro-6-phenylpyridazin-3(2H)-one, respectively, with 2-bromophenol or 2-iodophenol followed by Pd-catalyzed cyclodehydrohalogenation. Moreover, a new approach for the synthesis of 2-methyl-2,5-dihydro-1H-pyridazino[4,5-b] indol-1-ones was also elaborated utilizing a Heck-type ring closure reaction on 5-[(2-bromophenyl)amino]-2-methylpyridazin-3(2H)-ones which were obtained via Buchwald-Hartwig amination of 2-methyl-5-halopyridazin-3(2H)-ones with 2-bromoaniline.

The Diels-Alder Reaction of Pyridazinones as Dienophiles

The Diels-Alder reaction of 5-iodo (1a) and 5-ethylsulfonyl-2-methyl-3(2H)-pyridazinone (1b) with 2,3-dimethyl-1,3-butanediene afforded phthalazinone (3) and dihydrophthalazinone (2) as isolable products, respectively.The cycloadditions are well interpreted by the theoretical considerations based on the calculated AM1 data.