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15506-01-1

15506-01-1

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15506-01-1 Usage

Chemical Properties

White Solid

Uses

(7α,17β)-3-Methoxy-7-Methyl-estra-1,3,5(10)-trien-17-ol can be used in the preparation of alkylated estratrienes.

Check Digit Verification of cas no

The CAS Registry Mumber 15506-01-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,0 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15506-01:
(7*1)+(6*5)+(5*5)+(4*0)+(3*6)+(2*0)+(1*1)=81
81 % 10 = 1
So 15506-01-1 is a valid CAS Registry Number.

15506-01-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (7α,17β)-3-Methoxy-7-methyl-estra-1,3,5(10)-trien-17-ol

1.2 Other means of identification

Product number -
Other names (7R,8R,9S,13S,14S,17S)-3-methoxy-7,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15506-01-1 SDS

15506-01-1Relevant articles and documents

STRUCTURE-ACTIVITY RELATIONSHIPS OF ESTROGENS, EFFECTS OF 14-DEHYDROGENATION AND AXIAL METHYL GROUPS AT C-7, C-9 AND C-11

Gabbard, R. Bruce,Segaloff, Albert

, p. 791 - 805 (1983)

Thirty compounds were evaluated in the rat for uterotropic effects, inhibition of gonadotropin release, and competitive displacement of (3H) estradiol-17β from uterine cytosolic preparations. 7α-Methylestradiol-17β was 150percent as active as estradiol-17β as an uterotropic agent.Estradiol-17β was the most active inhibitor of gonadotropin release. 11β-Methylestradiol-17β had 124percent of the activity of estradiol-17β in displacing (3H) estradiol-17β from the "estrogen receptor." The 9α-methyl group considerably decreased the potency of estrogens in any of the three assays.The 14-dehydromodification was advantageous only in the estradiol-17β 3-methyl ether series.Uterotropic activities and inhibition of gonadotropin release did not parallel.The best compound for inhibiting gonadotropin release, as compared to uterotropic activity, was estrone.The "estrogen receptor" assay data correlated fairly well with uterotropic assay data, but only for compounds having free 3-hydroxyl groups; even so, some exceptions were noted.

PROCESS FOR THE PRODUCTION OF TIBOLONE

-

Page 35-36, (2010/02/08)

Disclosed is a process for the synthesis of 17β-hydroxy-7α-methyl- 19-nor-17α-pregn-5(10)-ene-20-yne-3-one (tibolone, 11) and intermediates useful for the synthesis thereof: (11).

Stereocontrolled derivatization of 3-methoxyestra-1,3,5(10), n-tetraenes via lewis acid promoted prins reactions, (n=7; 8(9))

Kuenzer, Hermann,Sauer, Gerhard,Wiechert, Rudolf

, p. 743 - 746 (2007/10/02)

Steroidal olefins 1 and 3 undergo dimethylaluminum chloride-mediated Prins reactions with paraformaldehyde to furnish homoallylic alcohols 4 and 16 as major products. These ene reaction-type intermediates are converted into 6 and 17 by hydroxyl group-assi

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