1575-47-9

Basic information

• Product Name: 4-phenylfuran-2(5H)-one
• CAS NO: 1575-47-9
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.1693
• Mol File: 1575-47-9.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 338.8°C at 760 mmHg
• Flash Point: 140.6°C
• Density: 1.215g/cm³
• Vapor Pressure: 9.6E-05mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 4-phenylfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylfuran-2(5H)-one(1575-47-9)
• EPA Substance Registry System: 4-phenylfuran-2(5H)-one(1575-47-9)

Safety Data

• Hazardous Substances Data: 1575-47-9(Hazardous Substances Data)

Upstream product

• 2243-35-8 2-acetoxyacetophenone 
• 3461-50-5 methyl trans-3-methylcinnamate 
• 100-34-5 benzene diazonium chloride 
• 497-23-4 2-buten-4-olide 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 34170-84-8 diethyl phosphonoacetic acid potassium salt 
• 70-11-1 α-bromoacetophenone 
• 591-50-4 iodobenzene 
• 145439-09-4 4-(tributylstannyl)-2,5-dihydrofuran-2-one 
• 220337-41-7 4-phenyl-3-tributylstannylfuran-2(5H)-one 
• 38111-44-3 phenylzinc(II) bromide 
• 471931-08-5 4-(p-toluenesulfonyloxy)-2(5H)-furanone 
• 4508-99-0 methyl γ-hydroxycrotonate 

Downstream Products

• 28784-56-7 3,6a-diphenyl-6,6a-dihydro-3aH-furo[3,4-d]isoxazol-4-one 
• 1575-55-9 5-bromo-4-phenyl-2(5H)-furanone 
• 1008-73-7 (R)-4-phenyl-4,5-dihydrofuran-2(3H)-one 
• 68844-05-3 4-phenyldihydrofuran-2-one 
• 1381783-44-3 3-diazo-4-phenyl-dihydrofuran-2-one 
• 120211-46-3 5-benzylidene-4-phenylfuran-2(5H)-one 

Relevant articles and documents

Palladium-catalyzed cross-coupling reactions of 4-tosyl-2(5H)-furanone with boronic acids: A facile and efficient route to generate 4-substituted 2(5H)-furanones

An efficient and facile synthesis of 4-substituted 2(5H)-furanones using palladium catalyzed cross-coupling reactions between 4-tosyl-2(5H)-furanone and boronic acids is reported herein.

Palladium-Catalyzed Cross-Coupling of Alkenyl Carboxylates

Carboxylate esters have many desirable features as electrophiles for catalytic cross-coupling: they are easy to access, robust during multistep synthesis, and mass-efficient in coupling reactions. Alkenyl carboxylates, a class of readily prepared non-aromatic electrophiles, remain difficult to functionalize through cross-coupling. We demonstrate that Pd catalysis is effective for coupling electron-deficient alkenyl carboxylates with arylboronic acids in the absence of base or oxidants. Furthermore, these reactions can proceed by two distinct mechanisms for C?O bond activation. A Pd0/II catalytic cycle is viable when using a Pd0 precatalyst, with turnover-limiting C?O oxidative addition; however, an alternative pathway that involves alkene carbopalladation and β-carboxyl elimination is proposed for PdII precatalysts. This work provides a clear path toward engaging myriad oxygen-based electrophiles in Pd-catalyzed cross-coupling.

Substituted aryl methyl radical Rubrolide compound and its preparation method and application

The invention discloses a substituted aryl methyl radical Rubrolide compound, its structure is shown as formula I: Wherein R is phenyl, pyridyl, pyrimidinyl, furyl, pyrazolyl, thiazolyl or thienyl, the R is one or more of the substituent of the substituted, the substituted the base is mutual independent, and is selected from one or more saturated or unsaturated alkyl, alkoxy, halogen, fluorine-containing methyl, nitro, cyano, ester or amide. The present invention provides substituted aryl-methyl radical Rubrolide compound of novel structure, which has a broad spectrum of herbicidal activity, can be used for various crops weed control. The invention also provides the preparation method and application.