159216-80-5Relevant articles and documents
Photocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride
Xu, Yangsen,Zhang, Zhaofei,Qiu, Chuntian,Chen, Shaoqin,Ling, Xiang,Su, Chenliang
, p. 582 - 589 (2020/12/09)
Photocatalytic water splitting technology (PWST) enables the direct use of water as appealing “liquid hydrogen source” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds. In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technology highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chemicals and pharmaceuticals from nitroarenes and amines with water and alkanols.
Synthesis, CNS and chloroquin resistance reversal activity of benzenepropanamines
Sharma,Bhandari, Kalpana,Shankar, Girija,Singh,Srivastava, Pratima,Pandey
, p. 207 - 211 (2007/10/03)
Several benzenepropanamines with a benzyl group attached to the 3-amino function are synthesized and evaluated for their CNS and chloroquin resistant reversal activity. The compounds are fully characterized by spectral and elemental analyses. These compounds are tested for their effect on gross behaviour and for antidepressant, anticonvulsant and anorexigenic activity. No effect is observed on gross behaviour where as most of them show fluoxetine like antireserpine and anorexigenic activity. Since this class of compounds have been reported to modulate the chloroquin resistance in P. falciparum, therefore these compounds are tested for chloroquin resistance reversal activity in vitro. Five compounds selectively inhibit P. falciparum heme oxygenase like fluoxetine.
N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation
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, (2008/06/13)
The invention provides the preparation procedure for N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3 -phenylpropylamine having the general formula (I), where R is hydrogen and the group of the general formula (II), in which R1/s
