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1644-71-9

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1644-71-9 Usage

Description

5-Bromo-4-fluorosalicylic acid is a chemical compound that belongs to the class of salicylic acids. It is a derivative of salicylic acid, characterized by the presence of a bromine and fluorine atom on the benzene ring. This unique structure endows it with versatile properties, making it a valuable intermediate in various chemical processes and a promising candidate for research and development.

Uses

Used in Pharmaceutical Industry:
5-Bromo-4-fluorosalicylic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its presence in the final products can enhance their therapeutic effects or improve their pharmacokinetic properties, such as solubility, stability, and bioavailability.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-4-fluorosalicylic acid serves as a key intermediate in the production of agrochemicals, including pesticides and herbicides. Its incorporation into these compounds can enhance their efficacy in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Dye Industry:
5-Bromo-4-fluorosalicylic acid is utilized in the dye industry as a precursor for the synthesis of various dyes. Its unique chemical structure allows for the creation of dyes with specific color properties, making it a valuable component in the production of textiles, paints, and other colorant applications.
Used in Materials Science:
5-Bromo-4-fluorosalicylic acid has potential applications in the field of materials science, where it can be used to develop new materials with specific properties. Its incorporation into polymers, for example, can result in materials with improved mechanical strength, thermal stability, or other desirable characteristics.
Used in Organic Chemistry Research and Development:
In the realm of organic chemistry, 5-Bromo-4-fluorosalicylic acid is employed as a reagent in various chemical reactions. Its unique structure allows for the formation of new compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science. Researchers can leverage its properties to explore new reaction pathways and develop innovative synthetic methods.
Used in Organic Building Blocks Production:
5-Bromo-4-fluorosalicylic acid is also used in the production of organic building blocks, which are essential components in the synthesis of a wide range of organic compounds. Its versatility and reactivity make it a valuable precursor for the creation of complex organic molecules with diverse applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 1644-71-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1644-71:
(6*1)+(5*6)+(4*4)+(3*4)+(2*7)+(1*1)=79
79 % 10 = 9
So 1644-71-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrFO3/c8-4-1-3(7(11)12)6(10)2-5(4)9/h1-2,10H,(H,11,12)

1644-71-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-4-fluoro-2-hydroxybenzoic acid

1.2 Other means of identification

Product number -
Other names 5-bromo-4-fluorosalicylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1644-71-9 SDS

1644-71-9Relevant articles and documents

Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens

Wu, Yongqi,Wang, Bin,Lu, Haijia,Zhao, Hongyi,Yang, Beibei,Li, Li,Lu, Yu,Zhang, Dongfeng,Sun, Ning,Huang, Haihong

supporting information, p. 3234 - 3248 (2021/04/06)

A series of conformationally constrained novel benzo[1,3]oxazinyloxazolidinones were designed, synthesized, and evaluated on their activities against Mycobacterium tuberculosis, Gram-positive bacteria, and Gram-negative bacteria. The studies identified a new compound 20aa that displayed good to excellent antibacterial and antitubercular profiles against drug-resistant TB strains (MIC = 0.48-0.82 μg/mL), MRSA (MIC = 0.25-0.5 μg/mL), MRSE (MIC = 1 μg/mL), VISA (MIC = 0.25 μg/mL), and VRE (MIC = 0.25 μg/mL) and some linezolid-resistant strains (MIC 1-2 μg/mL). Compound 20aa was demonstrated as a promising candidate through ADME/T evaluation including microsomal stability, cytotoxicity, and inhibition of hERG and monoamine oxidase. Notably, 20aa showed excellent mouse PK profile with high plasma exposure (AUC0-∞ = 78 669 h·ng/mL), high peak plasma concentration (Cmax = 10 253 ng/mL), appropriate half-life of 3.76 h, and superior oral bioavailability (128%). The present study not only successfully provides a novel benzo[1,3]oxazinyloxazolidinone scaffold with superior druggability but also lays a good foundation for new antibacterial drug development.

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

Wu, Yong-Qi,Lu, Hai-Jia,Zhao, Wen-Ting,Zhao, Hong-Yi,Lin, Zi-Yun,Zhang, Dong-Feng,Huang, Hai-Hong

supporting information, p. 813 - 822 (2020/02/15)

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

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Paragraph 00267, (2019/08/29)

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

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