1708-41-4

Basic information

• Product Name: 2-(1,3-DIOXOLAN-2-YL)FURAN
• Synonyms: FURFURAL ETHYLENE ACETAL;2-(1,3-DIOXOLAN-2-YL)FURAN;2-(2-FURYL)-1,3-DIOXOLANE;RARECHEM AL BP 0007;Furfural Ethylene Acetal 2-(2-Furyl)-1,3-dioxolane;2-Furfural ethylene glycol acetal;Furalane
• CAS NO: 1708-41-4
• Molecular Formula: C₇H₈O₃
• Molecular Weight: 140.14
• Mol File: 1708-41-4.mol
• Article Data: 42

Chemical Properties

• Melting Point: -41 °C
• Boiling Point: 76°C/1mmHg(lit.)
• Flash Point: 90.6 °C
• Appearance: /
• Density: 1,2 g/cm3
• Vapor Pressure: 0.344mmHg at 25°C
• Refractive Index: 1.4840-1.4870
• Storage Temp.: ?20°C
• CAS DataBase Reference: 2-(1,3-DIOXOLAN-2-YL)FURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-DIOXOLAN-2-YL)FURAN(1708-41-4)
• EPA Substance Registry System: 2-(1,3-DIOXOLAN-2-YL)FURAN(1708-41-4)

Safety Data

• Hazardous Substances Data: 1708-41-4(Hazardous Substances Data)

Usage

General Description

2-(1,3-Dioxolan-2-yl)furane, also known as Dioxolane, is a chemical compound with the molecular formula C6H8O3. It is a colorless liquid that is commonly used as a solvent in various industrial processes, such as in the production of pharmaceuticals and as a stabilizer in the food industry. Dioxolane is also used as a reagent in the synthesis of other organic compounds and as a component in the production of perfumes and flavorings. Additionally, it can be found in some consumer products, such as adhesives and coatings. However, it is important to handle this chemical with care, as it may have harmful effects if inhaled, swallowed, or in contact with skin.

InChI:InChI=1/C7H8O3/c1-2-6(8-3-1)7-9-4-5-10-7/h1-3,7H,4-5H2

Upstream product

• 98-01-1 furfural 
• 107-21-1 ethylene glycol 
• 107-07-3 2-chloro-ethanol 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 

Downstream Products

• 3238-40-2 furan-2,5-dicarboxylic acid 
• 59259-01-7 2-<2-(1,3-dioxolanyl)>benzaldehyde 
• 68348-23-2 3-(1,3-dioxolan-2-yl)benzaldehyde 
• 23691-81-8 methyl 2-(1,3-dioxolan-2-yl)benzoate 
• 124038-36-4 3-[1,3]Dioxolan-2-yl-benzoic acid methyl ester 
• 153329-05-6 1-(3-(1,3-dioxolan-2-yl)phenyl)ethanone 
• 1256467-20-5 (1,3-dioxolan-2-yl)phenylethanone 
• 98-01-1 furfural 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 2167-14-8 1-ethyl-1H-pyrrole-2-carbaldehyde 
• 24964-64-5 3-Cyanobenzaldehyde 
• 7468-67-9 o-formylbenzonitrile 
• 35849-11-7 2-(1,3-dioxolan-2-yl)benzonitrile 
• 153329-04-5 3-(1,3-dioxolan-2-yl)-benzonitrile 

Relevant articles and documents

An Efficient Method for the Acetalization of α,β-Unsaturated Aldehydes

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New efficient Synthesis of Furanoacetylene Phytoalexins Wyerone and Dihydrowyerone

Furanoacetylene phytoalexins wyerone 1a and dihydrowyerone 1b were efficiently synthesized in multigram quantities starting from furfural.The key step involved an acylation by acetylenic N-methoxy-N-methylamides 3a,b. Key words: Phytoalexins, dihydrowyerone, wyerone, N-methoxy-N-methylamides.

Synthesis of amides and esters containing furan rings under microwave-assisted conditions

In this work, we present a novel method for the synthesis of ester and amide derivatives containing furan rings (furfural derivatives) under mild synthetic conditions supported by microwave radiation. N-(Furan-2-ylmethyl)furan-2-carboxamide and furan-2-ylmethyl furan-2-carboxylate were produced using 2-furoic acid, furfurylamine, and furfuryl alcohol. The reactions were carried out in a microwave reactor in the presence of effective coupling reagents: DMT/NMM/TsO? or EDC. The reaction time, the solvent, and the amounts of the substrates were optimized. After crystallization or flash chromatography, the final compounds were isolated with good or very good yields. Our method allows for the synthesis of N-blocked amides using N-blocked amino acids (Boc, Cbz, Fmoc) and amine. As well as compounds with a monoamide and ester moiety, products with diamides and diester bonds (N,N-bis(furan-2-ylmethyl) furan-2,5-dicarboxamide, bis(furan-2-ylmethyl) furan-2,5dicarboxylate, and furan-3,4-diylbis(methylene) bis(furan-2-carboxylate)) were synthesized with moderate yields in the presence of DMT/NMM/TsO– or EDC, using 2,5-furan-dicarboxylic acid and 3,4-bis(hydroxymethyl)furan as substrates.

Zeolite-catalyzed acetalization reaction of furfural with alcohol under solvent-free conditions

Acetalization reactions present a viable method for producing valuable chemicals and protecting carbonyl functionalities in organic compounds. Herein, several commercial zeolites were used as solid acid catalysts in the acetalization of biomass-derived furfural with alcohols under solvent-free conditions. The effects of major reaction parameters such as catalyst concentration, reaction temperature, and reaction time were investigated. Among the tested catalysts, SAPO-34 with appropriate acid sites and textural structure exhibited the highest catalytic activity under optimized reaction conditions. Additionally, the catalyst showed excellent recyclability and no obvious deactivation was observed even after using it six times.