1770840-43-1

Basic information

• Product Name: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
• Synonyms: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
• CAS NO: 1770840-43-1
• Molecular Weight: 260.037
• Mol File: 1770840-43-1.mol
• Article Data: 17

Chemical Properties

• Density: 2.43±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(1770840-43-1)
• EPA Substance Registry System: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(1770840-43-1)

Safety Data

• Hazardous Substances Data: 1770840-43-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1770840-43-1 differently. You can refer to the following data:
1. 4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs.
2. 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful reagent in the synthesis of phosphoramidate GS-5734 prodrug for potential treatment of Ebola virus infections and in the preparation of Remdesivir as COVID-19 antiviral drug candidate.

Upstream product

• 888720-29-4 4-chloropyrrolo[1,2-f][1,2,4]triazine 
• 159326-71-3 pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one 
• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 1003-29-8 2-pyrrole aldehyde 
• 159326-68-8 pyrrolo[2,1-f][1,2,4]triazin-4-amine 

Downstream Products

• 158227-80-6 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 1911578-75-0 (2S)-2-ethylbutyl 2-(((R)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 

Relevant articles and documents

Synthesis method of remdesivir intermediate triazinamine derivative

The invention discloses a synthesis method of a remdesivir intermediate triazinamine derivative. The remdesivir intermediate triazinamine derivative is prepared by adopting a unique synthesis method. The invention solves the problems of expensive raw materials, large amount of wastewater in the production process and the like in existing reaction of a remdesivir intermediate triazinamine derivative, and provides the novel synthesis method of the remdesivir intermediate triazinamine derivative, wherein the synthesis method has the advantages of simple preparation method, cheap and easily available raw materials, greatly reduced production cost, less wastewater and the like; the synthesis method is never reported in the prior art, is a brand-new preparation method of the remdesivir intermediate triazinamine derivative, and provides a new synthesis idea for similar compounds of remdesivir.

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

The kinetoplastid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are the causative agents of neglected tropical diseases with a serious burden in several parts of the world. These parasites are incapable of synthesizing purines de nov

Novel synthesis method of compound 7-iodopyrrolo[2, 1-f][1, 2, 4]triazin-4-amine

The invention provides a method for preparing a triazine compound as shown in a formula (I). According to the invention, pyruvic acid and formamidine are taken as starting materials to synthesize an intermediate, and the intermediate is subjected to two-step reaction to obtain the compound shown in the formula (I). The method provided by the invention is mild in condition, simple and convenient to operate, capable of greatly reducing the cost and suitable for industrial mass production.