1911578-75-0Relevant articles and documents
Total synthesis of remdesivir
Kumar Palli, Kishore,Ghosh, Palash,Krishna Avula, Shiva,Sridhara Shanmukha Rao,Patil, Amol D.,Ghosh, Subhash,Sudhakar, Gangarajula,Raji Reddy, Chada,Mainkar, Prathama S.,Chandrasekhar, Srivari
supporting information, (2021/12/20)
Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield.
Preparation and analysis method of Sedellovir isomer
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Paragraph 0016; 0114-0116, (2021/10/13)
Through the preparation method provided by the invention, high-purity isomer compounds can be obtained; and the analysis method provided by the invention can realize effective separation of isomers and Sedgetalis, and has the advantages of simple and conv
Preparation method of ridecevir compound
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Paragraph 0060-0063, (2021/08/07)
The invention belongs to the field of medicinal chemistry, and particularly relates to a novel synthesis and preparation method of a ridecevir compound. (2R, 3R, 4R, 5R)-2-(4-aminopyrrole[2, 1-f][1, 2, 4]triazin-7-yl)-3, 4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-nitrile is taken as an initial raw material, and is subjected to ketal protection, BC protection, resolution, phosphorylation reaction, substitution reaction and deprotection reaction to prepare ridecevir. The method has the advantages of mild and easily-controlled reaction conditions, simple operation, high product yield and high purity, and is suitable for industrial mass production.