1911578-75-0

Usage

Uses

Used in Cellular Energy Metabolism:
ATP is used as an energy source for powering numerous cellular processes, including muscle contractions, nerve impulses, and protein synthesis. The release of one phosphate group from ATP generates a significant amount of energy, which is essential for maintaining cellular function and survival.
Used in Energy Storage and Transfer:
ATP is involved in the storage and transfer of energy within the cell, ensuring that cells have a readily available supply of energy to meet their metabolic demands.
Used in Pharmaceutical and Biomedical Research:
ATP is utilized in various research applications, such as studying cellular energy metabolism, developing new drugs targeting energy-related pathways, and understanding the role of ATP in various diseases and conditions.
Used in Food and Nutrition Industry:
ATP is sometimes used as a dietary supplement to support energy production in the body, although its effectiveness and safety are still under investigation.
Used in Cosmetics and Skincare:
ATP is incorporated into some cosmetic and skincare products, where it is believed to help support skin cell energy production and promote overall skin health.
Used in Agricultural and Plant Sciences:
ATP plays a role in plant growth and development, and research on ATP can contribute to the development of more efficient and sustainable agricultural practices.

Upstream product

• 1355049-94-3 (3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol 
• 1191237-68-9 (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile 
• 1191237-69-0 (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile 
• 1911578-98-7 (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester 
• 1770840-43-1 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine 
• 1355357-49-1 (2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile 
• 946511-97-3 2-ethylbutyl (S)-2-aminopropanoate hydrochloride 
• 770-12-7 O-phenyl phosphorodichloridate 
• 159326-68-8 pyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 16838-89-4 2,3,5-tri-O-benzyl-D-ribofuranose 
• 1439900-56-7 (2S)-2-ethylbutyl 2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate 
• 261909-49-3 phenyl(isopropoxy-L-alaninyl) phosphorochloridate 
• 1355049-92-1 2-ethylbutyl (2S)-2-{[chloro(phenoxy)phosphoryl]amino}propanoate 

Downstream Products

• 1911579-04-8 GS-704277 

Relevant academic research and scientific papers

Total synthesis of remdesivir

Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield.

Preparation method of remdesivir

The invention relates to the technical field of medical intermediates, in particular to a preparation method of remdesivir. A synthesis route of the remdesivir includes the following steps: 1) reacting a compound I with a compound II in the presence of Lewis acid and alkali to obtain a compound III; and 2) reacting the compound III with a compound IV in the presence of a hydroxyl activator and alkali to obtain a compound V. The invention effectively solves problems that the synthesis route is tedious in step, purification is not easy, and the risk that genotoxic impurities exist in the prior art. Meanwhile, the whole route is mild in reaction condition, operation is convenient, and the yield and purity are high, and the preparation method is suitable for industrial large-scale production.

Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation

Remdesivir, an inhibitor of RNA-dependent RNA polymerase developed by Gilead Sciences, has been used for the treatment of COVID-19. The synthesis of remdesivir is, however, challenging, and the overall cost is relatively high. Particularly, the stereoselective assembly of the P-chirogenic center requires recrystallization of a 1:1 isomeric p-nitrophenylphosphoramidate mixture several times to obtain the desired diastereoisomer (39%) for further coupling with the d-ribose-derived 5-alcohol. To address this problem, a variety of chiral bicyclic imidazoles were synthesized as organocatalysts for stereoselective (S)-P-phosphoramidation employing a 1:1 diastereomeric mixture of phosphoramidoyl chloridates as the coupling reagent to avoid a waste of the other diastereomer. Through a systematic study of different catalysts at different temperatures and concentrations, a mixture of the (S)- and (R)-P-phosphoramidates was obtained in 97% yield with a 96.1/3.9 ratio when 20 mol % of the chiral imidazole-cinnamaldehyde-derived carbamate was utilized in the reaction at -20 °C. A 10-g scale one-pot synthesis via a combination of (S)-P-phosphoramidation and protecting group removal followed by one-step recrystallization gave remdesivir in 70% yield and 99.3/0.7 d.r. The organocatalyst was recovered in 83% yield for reuse, and similar results were obtained. This one-pot process offers an excellent opportunity for industrial production of remdesivir.

Method for preparing retegravir by using micro-channel reactor

The invention discloses a method for synthesizing retegravir by using a micro-channel reactor, which realizes continuous flow synthesis of retegravir by using a scale effect of a micro-flow field technology and using a novel micro-channel reactor to repla

ISOMORPHS OF REMDESIVIR AND METHODS FOR SYNTHESIS OF SAME

A new isoform of 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3/4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate (Remdesivir) having increased water solubility is disclosed, along with methods

N-protected heterocyclic compound, preparation method thereof and method for preparing C-nucleoside derivative by using N-protected heterocyclic compound

The invention provides an N-protected heterocyclic compound, a preparation method thereof and a method for preparing a C-nucleoside derivative by using the N-protected heterocyclic compound. Specifically, the invention provides a method for preparing the C-nucleoside derivative by using a heterocyclic compound protected by N-carbobenzoxy or N-tert-butyloxycarboryl. According to the method, halogenation is not needed, temporary amino protection is not needed, protons of the heterocyclic compound are removed by directly using an organic lithium or organic magnesium compound, and addition with ribose lactone is carried out. According to the method, the synthesis route of the C-nucleoside derivative is shortened, and the yield of the reaction of the heterocyclic compound and the ribose lactone is remarkably improved under the condition that no halogen atom is used as a substituent group.

Preparation method of ridecevir compound

The invention belongs to the field of medicinal chemistry, and particularly relates to a novel synthesis and preparation method of a ridecevir compound. (2R, 3R, 4R, 5R)-2-(4-aminopyrrole[2, 1-f][1, 2, 4]triazin-7-yl)-3, 4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-nitrile is taken as an initial raw material, and is subjected to ketal protection, BC protection, resolution, phosphorylation reaction, substitution reaction and deprotection reaction to prepare ridecevir. The method has the advantages of mild and easily-controlled reaction conditions, simple operation, high product yield and high purity, and is suitable for industrial mass production.

Synthesis method of antiviral drug ridexivir and intermediate thereof

The invention discloses a synthesis method of an antiviral drug retegravir, which comprises the following steps: carrying out addition reaction on a compound 1 and a compound 2 to obtain a compound 3,carrying out cyanation reaction under the action of Lewis acid to obtain a compound 4, carrying out copper-catalyzed ammonolysis reaction to obtain a compound 5, carrying out palladium-catalyzed hydrogenation debenzylation to obtain a compound 6, and finally, reacting with a compound 7 to obtain a retegravir product. According to the method, the compound 1 is directly used as a raw material, no extra active hydrogen exists, and the reaction yield is high,the method has the advantages of simple operation, no amino interference, high cyanation reaction yield, clean and efficient palladium-carbon alkylation debenzylation reaction, convenient palladium-carbon recovery, and less three wastes. In addition, the leaving group of the compound 7 is improved to improve the activity of the compound 7, and the unprotected docking reaction of 6 and 7 is optimized by adding a proper auxiliary agent, so that the selectivity and the reaction yield can be greatly improved. The route is simple to operate, high in total yield, high in product purity and suitable for large-scale production.

Preparation method of high-purity Remdesivir

The invention belongs to the field of medicinal chemistry, and particularly relates to a preparation method of a compound Remdesivir as shown in a formula I defined in the description. The method is simple and convenient to operate, mild in reaction condi

Synthesis method of

The method comprises the following steps: (2R, 3R, 4S, 5R) -2 - (4 - 2) [1 - f, 1, 2] triazine 4-yl) -7 -3-hydroxy 4 - (hydroxymethyl) tetrahydrofuran -5 -2 - carbonitrile. 2,2 - Dimethoxypropane and first acid catalyst were added first solvent, stirred,