18065-78-6

Basic information

• Product Name: 1-(2-phenylethyl)pyridin-2(1H)-one
• CAS NO: 18065-78-6
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.2484
• Mol File: 18065-78-6.mol

Chemical Properties

• Boiling Point: 401.5°C at 760 mmHg
• Flash Point: 195.4°C
• Density: 1.113g/cm³
• Vapor Pressure: 1.18E-06mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(2-phenylethyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-phenylethyl)pyridin-2(1H)-one(18065-78-6)
• EPA Substance Registry System: 1-(2-phenylethyl)pyridin-2(1H)-one(18065-78-6)

Safety Data

• Hazardous Substances Data: 18065-78-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1-(2-phenylethyl)pyridin-2(1H)-one is used as a research compound for its potential anti-inflammatory and anti-cancer properties. It is being investigated for its ability to inhibit certain enzymes involved in disease processes, which could lead to the development of new therapeutic agents for various medical conditions.
Used in Drug Development:
In the pharmaceutical industry, 1-(2-phenylethyl)pyridin-2(1H)-one is used as a potential drug candidate. Its study is focused on understanding its mechanisms of action and evaluating its efficacy and safety in treating specific diseases. 1-(2-phenylethyl)pyridin-2(1H)-one's potential applications in drug development are being explored to bring forth novel treatments for patients in need.
Used in Enzyme Inhibition Studies:
1-(2-phenylethyl)pyridin-2(1H)-one is also used as a tool in enzyme inhibition studies. Its ability to inhibit certain enzymes makes it a valuable compound for understanding the roles these enzymes play in disease processes and for developing targeted therapies that can disrupt these processes.
Overall, 1-(2-phenylethyl)pyridin-2(1H)-one is a versatile compound with potential applications in various areas of pharmaceutical research and development, making it an important compound for ongoing scientific investigation.

Upstream product

• 109-06-8 α-picoline 
• 103-63-9 1-phenyl-2-bromoethane 
• 6324-18-1 1-(2-phenylethyl)pyridinium bromide 
• 142-08-5 2-Pyridone 
• 60-12-8 2-phenylethanol 
• 92039-54-8 1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 142-08-5 2-hydroxypyridin 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 110-86-1 pyridine 
• 17376-04-4 2-phenethyl iodide 

Downstream Products

• 18065-79-7 2-chloro-1-phenethyl]-pyridinium; iodide 
• 111911-81-0 7-oxo-6-phenethyl-6-azabicyclo<3.2.1>oct-2-ene-2-carboxylic acid 
• 120491-74-9 3,5-Dibromo-1-phenethyl-1H-pyridin-2-one 
• 120491-75-0 3,5-diiodo-1-phenethylpyridin-2(1H)-one 

Relevant articles and documents

Catalytic O- to N-Alkyl Migratory Rearrangement: Transition Metal-Free Direct and Tandem Routes to N-Alkylated Pyridones and Benzothiazolones

The present study reports the synthesis of N-alkylated pyridones and benzothiazolones via O- to N-alkyl group migration under transition metal-free TfOH-catalyzed reaction conditions for the first time, to the best of our knowledge. Primary as well as secondary alkyl groups smoothly migrate under the present reaction conditions. Moreover, a minor modification of the protocol used in this study is found to be applicable for an entirely new tandem synthesis of 2-alkoxy-N-heterocycles from the simplest starting materials in a solvent-free reaction conditions. Density Functional Theory (DFT) calculation identifies the energy species associated with the rearrangement, whereas, mechanistic experiments explore the role of the catalyst as the alkyl group transfer mediator. (Figure presented.).

Specific N-Alkylation of Hydroxypyridines Achieved by a Catalyst- and Base-Free Reaction with Organohalides

A specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and

Iron-catalyzed regioselective direct arylation at the C-3 position of N-alkyl-2-pyridone

A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C-H functionalization.

Value of zeolites in asymmetric induction during photocyclization of pyridones, cyclohexadienones and naphthalenones

Two strategies, namely chiral inductor and chiral auxiliary approaches, have been examined within zeolites with the aim of achieving asymmetric induction during the photocyclization of cyclohexadienone, naphthalenone and pyridone derivatives. Within zeoli

N- vs. O-alkylation in the Mitsunobu reaction of 2-pyridone

An N- vs. O-alkylation study of 2-pyridone with various alcohols and solvents under Mitsunobu conditions was carried out.

Sodium mercury edetate dehydrogenation of N-aliphatic substituted 1,2,3,6-tetrahydropyridine derivatives

Hg(II)-edta dehydrogenation of N-aliphatic substituted Δ3-piperideine 1 leads to polymers. From 4 carrying a hydroxy neighbour group in the aliphatic side chain, it is possible to yield definite oxidation products - in dependence of nucleophiles present - mainly 4-substituted piperidone-2 derivatives 5 and 9-12. The oxidation of corresponding 4-hydroxy- (19) or 4-amino- (20, 21) piperidines gives the same spectrum of products. A mechanism for all the reactions is proposed.