190011-87-1

Basic information

• Product Name: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE
• Synonyms: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE;TIMTEC-BB SBB003775;3-Chloro-2,6-difluorobenzaldehyde 97%
• CAS NO: 190011-87-1
• Molecular Formula: C₇H₃ClF₂O
• Molecular Weight: 176.55
• Product Categories: Benzaldehyde;Aldehydes;C7;Carbonyl Compounds
• Mol File: 190011-87-1.mol

Chemical Properties

• Melting Point: 46-49 °C(lit.)
• Boiling Point: 207.833 °C at 760 mmHg
• Flash Point: 216 °F
• Appearance: /
• Density: 1.453 g/cm³
• Vapor Pressure: 0.221mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(190011-87-1)
• EPA Substance Registry System: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(190011-87-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 190011-87-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2,6-difluorobenzaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure with a chlorine and two fluorine atoms allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Chemical Synthesis:
In the field of organic chemistry, 3-chloro-2,6-difluorobenzaldehyde serves as a key building block for the creation of a wide range of chemical compounds. Its reactivity and functional group compatibility make it a valuable component in the synthesis of various organic molecules, including agrochemicals, dyes, and specialty chemicals.
Used in Material Science:
3-Chloro-2,6-difluorobenzaldehyde can be utilized in the development of novel materials with specific properties, such as enhanced thermal stability, chemical resistance, or optical characteristics. Its incorporation into polymers or other materials can lead to improved performance in various applications, including electronics, coatings, and adhesives.
Used in Research and Development:
Due to its unique structural features, 3-chloro-2,6-difluorobenzaldehyde is an important compound for research and development purposes. It can be used to study the effects of halogen substitution on the properties of benzaldehyde derivatives and to explore new reaction pathways and synthetic strategies in organic chemistry.

InChI:InChI=1/C7H3ClF2O/c8-5-1-2-6(9)4(3-11)7(5)10/h1-3H

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 109-72-8 n-butyllithium 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 252004-35-6 (3-chloro-2,6-difluoro-phenyl)-methanol 

Downstream Products

• 942319-19-9 (E)-3-(3-chloro-2,6-difluoro-phenyl)acrylic acid 
• 1422510-33-5 (S)-N-((S)-1-(3-chloro-2,6-difluorophenyl)but-3-en-1-yl)-2-methylpropane-2-sulfmamide 
• 1336270-00-8 C₁₀H₁₀ClF₂N 
• 1422510-34-6 (S)-phenyl (1-(3-chloro-2,6-difluorophenyl)but-3-en-1-yl)carbamate 
• 1422510-31-3 (S)-phenyl (1-(3-chloro-2,6-difluorophenyl)-3-oxopropyl)carbamate 
• 1422509-98-5 1-(3-chloro-2,6-difluorophenyl)prop-2-en-1-one 
• 1422510-61-9 1-(3-chloro-2,6-difluorophenyl)-3-iodo(1-²H)propan-1-(²H)ol 
• 1422509-99-6 1-(3-chloro-2,6-difluorophenyl)-3-iodopropan-1-one 
• 1422511-22-5 (1R)-1-(3-chloro-2,6-difluorophenyl)-3-iodopropan-1-ol 
• 1422511-23-6 (1S)-1-(3-chloro-2,6-difluorophenyl)-3-iodopropan-1-ol 
• 1422510-91-5 methyl N-[(10R,14S)-14-{[3-(3-chloro-2,6-difluorophenyl)-3-hydroxypropyl]amino}-10-methyl-9-oxo-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate 
• 1422510-92-6 methyl N-[(10R,14S)-14-[6-(3-chloro-2,6-difluorophenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-16-{[2-(trimethylsilyl)ethoxy]methyl}-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate 
• 1422508-12-0 methyl N-[(10R,14S)-14-[(6R)-6-(3-chloro-2,6-difluorophenyl)-2-oxo-1,3-oxazinan-3-yl]-10-methyl-9-oxo-8,16,18-triazatricyclo[13.2.1.0^2,7]octadeca-1⁽¹⁷⁾,2,4,6,15⁽¹⁸⁾-pentaen-5-yl]carbamate 
• 1422511-13-4 methyl N-[(12E,15S)-18-chloro-15-{[3-(3-chloro-2,6-difluorophenyl)-3-oxopropyl]amino}-9-oxo-17-{[2-(trimethylsilyl)ethoxy]methyl}-8,17,19-triazatricyclo[14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate 

Relevant articles and documents

MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

2″-deoxy hygromycin derivatives

This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1and R2are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

Pharmaceutically active compounds

Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group --(CH2)c NHCO2 R10, a group --(CH2)c NR5 R6, or a group --CO2 R11 ; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group --NHCO2 R10 ; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)a Z(CH2)b ; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.