20073-50-1

Basic information

• Product Name: 2-(3-OXAZOLIDINE)ETHANOL
• Synonyms: 3-oxazolidineethanol;2-(3-OXAZOLIDINE)ETHANOL;N-(2-HYDROXYETHYL)OXAZOLIDINE;TIMTEC-BB SBB008304;oxazolidine-3-ethanol;Einecs 243-499-2
• CAS NO: 20073-50-1
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• EINECS: 243-499-2
• Mol File: 20073-50-1.mol

Chemical Properties

• Boiling Point: 206.8°Cat760mmHg
• Flash Point: 78.8°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.0549mmHg at 25°C
• Refractive Index: 1.475
• Water Solubility: 1000g/L at 25℃
• CAS DataBase Reference: 2-(3-OXAZOLIDINE)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-OXAZOLIDINE)ETHANOL(20073-50-1)
• EPA Substance Registry System: 2-(3-OXAZOLIDINE)ETHANOL(20073-50-1)

Safety Data

• Hazardous Substances Data: 20073-50-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(3-OXAZOLIDINE)ETHANOL is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of diverse chemical entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(3-OXAZOLIDINE)ETHANOL is utilized as a chelating agent for metal ion removal, which is essential in the purification and stabilization of various agrochemical products.
Used in Materials Science:
2-(3-OXAZOLIDINE)ETHANOL is employed as a reagent in organic chemistry reactions within the field of materials science, enabling the synthesis of novel materials with specific properties for various applications.
It is crucial to handle 2-(3-OXAZOLIDINE)ETHANOL with care and adhere to safety protocols to mitigate any potential hazards associated with its use.

InChI:InChI=1/C5H11NO2/c7-3-1-6-2-4-8-5-6/h7H,1-5H2

Upstream product

• 50-00-0 formaldehyd 
• 111-42-2 2,2'-iminobis[ethanol] 
• 590-86-3 isovaleraldehyde 
• 71-36-3 butan-1-ol 

Downstream Products

• 86241-19-2 2-(bis(2-hydroxyethyl)amino)acetonitrile 
• 105-59-9 N-Methyldiethanolamine 
• 1424252-24-3 C₄₆H₇₁NO₇ 
• 1424252-22-1 C₄₆H₇₁NO₇ 
• 1424252-16-3 C₃₀H₅₅NO₅ 
• 1424252-14-1 C₃₀H₅₅NO₅ 
• 1424252-10-7 C₂₆H₄₇NO₃ 
• 1424252-12-9 C₂₆H₄₇NO₃ 
• 1462469-84-6 (E)-6-(2-(3-oxazolidinyl)ethoxy)-2-(4-dimethylaminostyryl)benzofuran 
• 99614-02-5 ondanserton 
• 120635-47-4 4,5,6,8,9,10-hexahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-11H-pyrido-[3,2,1-jk]-carbazol-11-one 
• 154198-23-9 2-<(bis-2-hydroxyethyl)aminomethyl>-3,5-dimethoxy-6-formylphenol 
• 105892-13-5 (4-Chloro-phenylsulfanyl)-acetic acid; compound with 2-oxazolidin-3-yl-ethanol 
• 17816-81-8 1-benzoyloxy-2-oxazolidin-3-yl-ethane 

Relevant articles and documents

Synthesis and characterization of different types of epoxide-based Mannich polyols from low-cost cashew nut shell liquid

Cashew nut shell liquid (CNSL) is a natural aromatic organic oil consisting of phenolic compounds with interesting structures. Extraction of CNSL was performed in a Soxhlet apparatus. The major (90 %) component of CNSL is anacardic acid, which is easily decarboxylated to cardanol (10 %) by use of conventional methods. In this paper we describe a three-step synthesis of Mannich polyols for rigid foams. The first step is synthesis of N-(2-hydroxyethyl)-1,3-oxazolidine (the Mannich precursor) by condensation of paraformaldehyde and diethanolamine. The second step involves synthesis of the Mannich base phenolic ring of cardanol by reaction with N-(2-hydroxyethyl)-1,3- oxazolidine. The third step is alkoxylation. The synthesized polyols were characterized by FTIR and 1H NMR spectroscopy and thin-layer chromatography. Springer Science+Business Media Dordrecht 2013.

Aldehydes containing hydroxl groups

The present invention relates to aldehydes of the formula (I) which contain tertiary amino groups and at least one hydroxyl group. Aldehydes of this kind can be utilized broadly. Aldehydes of particular advantage can be incorporated into a polymer, and find use as curing agents and/or catalysts. Preferably they find use in adhesives and sealants.

Synthesis and antimicrobial properties of 3-(β-hydroxyethyl)-1,3- oxazolidins

The possibility of synthesis of 3-(β-hydroxyethyl)-1,3-oxazolidin and its substituted derivatives at position 2 by the condensation-heterocyclization of diethanolamine with certain aldehydes and ketones was examined. The structure of the compounds was identifi ed by NMR spectroscopy. We investigated antimicrobial properties of the synthesized compounds against microorganisms that affect the lube oil M-11 and found a dependence of the antimicrobial properties on the nature of the substituent at position 2 of oxazolidin heterocycle.

PREPARATION OF DELMOPINOL

It comprises a process for the production of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by subjecting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6) alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6) cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4) alkyl, phenyl, and phenyl mono- ordisubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process. .

Synthesis of N-substituted oxazolidines and morpholines

A series of N-substituted oxazolidines and morpholines were prepared and characterized.

NOVEL PROCESS FOR THE PREPARATION OF IMIDAZOLYL COMPOUNDS

The present invention relates to a method for the preparation of an imidazolyl compound of the general formula (I), wherein: Ra and Rb each separately are (C1-C6)alkyl, (C1-C6)alkoxyalkyl, optionally substituted aryl or heteroaryl; or wherein Ra and Rb together form a further homocyclic or heterocyclic system comprising one or more rings; Ra’ and Rb’ each are hydrogen or together form a carbon-carbon double bond, said carbon-carbon double bond optionally being part of an aromatic system; Rc is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1,-C6)alkoxyalkyl or halogen; Rd is hydrogen or (C1-C4)aIkyl; Re is hydrogen or (C1-C4)aIkyl; m is 1 or 2; and R1, is hydrogen or (C1-C4)aIkyl; as well as its acid addition salt;characterized in that a compound of the general formula (II) is reacted with a compound of the formula (III), wherein: R is a hydrogen, a (C1-C4)alkyl group optionally substituted with a hydroxygroup or an optionally substituted aryl group, R', R", R'" and R"" each individually are a hydrogen or a (C1-C4)aIkyl group; followed by a reaction with a compound of the formula (IV), wherein R1, Rd and Re have the meanings defined above; and optionally followed by a reaction with a suitable acid. De method according to the present invention is especially useful for the preparation of ondansetron and cilansetron.

Synthesis of unsymmetrical dinucleating ligands bearing nitrogen and oxygen donor atoms

The synthesis of unsymmetrical dinucleating ligands bearing nitrogen and oxygen donor atoms is described. The Schiff-base condensation of functionalised salicylaldehyde derivatives with primary amines gave rise to unsymmetrical unsaturated ligands, whereas condensation with secondary amines followed by in situ reduction of the iminium species with sodium borohydride, led to the formation of unsymmetrical saturated ligands. The latter were also prepared by the tandem Mannich reactions of 4-chlororesorcinol.

Method of decolorizing mixtures of T-butyl alkylphenols with N-(2-hydroxyethyl)oxazolidine

A method of eliminating color-causing impurities in mixtures of t-butyl alkylphenols by treatment with N-(2-hydroxyethyl)oxazolidine at 90° C. and at atmospheric pressure is described. These phenols are used as peroxide inhibitors in polyoxyalkylene glycols for polyurethane foams. Discoloration of the polyol occurs if the phenol mixture is not treated with N-(2-hydroxyethyl)oxazolidine. The t-butyl alkylphenol mixture is derived from an alkylphenol made over an acid catalyst.