20432-02-4

Basic information

• Product Name: (2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one
• Synonyms: (2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one;(E)-1-(4-Nitrophenyl)-3-phenyl-2-propen-1-one;2-Propen-1-one, 1-(4-nitrophenyl)-3-phenyl-, (E)- (9ci);Chalcone, 4'-nitro-, (E)-;(2E)-1-(4-nitrophenyl)-3-phenylprop-2-en-1-one
• CAS NO: 20432-02-4
• Molecular Formula: C₁₅H₁₁NO₃
• Molecular Weight: 253.2527
• Mol File: 20432-02-4.mol
• Article Data: 115

Chemical Properties

• Boiling Point: 441°Cat760mmHg
• Flash Point: 214.9°C
• Appearance: /
• Density: 1.255g/cm³
• CAS DataBase Reference: (2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one(20432-02-4)
• EPA Substance Registry System: (2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one(20432-02-4)

Safety Data

• Hazardous Substances Data: 20432-02-4(Hazardous Substances Data)

Usage

General Description

(2E)-1-(4-Nitrophenyl)-3-phenyl-2-propene-1-one, also known as p-nitrochalcone, is a chemical compound with the formula C15H11NO3. It is a bright yellow solid that is insoluble in water but soluble in organic solvents. It is often used as a precursor in the synthesis of other chemical compounds such as flavonoids and dyes. P-nitrochalcone has also been studied for its potential medicinal properties, including its ability to inhibit the growth of certain cancer cells and its anti-inflammatory effects. Its structure consists of a chalcone backbone with a nitro group attached to the phenyl ring, making it a versatile building block for various chemical reactions and applications.

Upstream product

• 17638-55-0 P-phenacyltriphenylphosphonium cation 
• 555-16-8 4-nitrobenzaldehdye 
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• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 1439-43-6 1-(4-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 100-19-6 (4-nitrophenyl)ethanone 
• 552-89-6 2-nitro-benzaldehyde 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 66680-87-3 (Z)-tributyl(styryl)stannane 
• 19372-00-0 1-(trimethylsilyl)-2-phenylethene 

Downstream Products

• 118757-40-7 5-(4-Nitro-phenyl)-7-phenyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 121567-86-0 5-(4-Nitro-phenyl)-7-phenyl-4,7-dihydro-tetrazolo[1,5-a]pyrimidine 
• 150356-92-6 2,3-dihydro-7-(4-nitrophenyl)-5-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one 
• 113854-32-3 3-Methyl-6-(4-nitro-phenyl)-1,4-diphenyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridine 
• 107710-47-4 4-(4'-nitrophenyl)-6-phenyl-4-hydroxy-tetrahydro-1,3-thiazine-2-thione 
• 54914-77-1 1-(4-nitrophenyl)-3-phenyl-1-propanone 
• 122-78-1 phenylacetaldehyde 
• 62-23-7 4-nitro-benzoic acid 
• 72758-64-6 (Z)-4'-nitrochalcone 
• 40327-57-9 trans-2,3-epoxy-1-(4-nitrophenyl)-3-phenylpropan-1-one 
• 92744-66-6 1-(p-Nitrophenyl)-3-phenyl-3-(2'-oxocyclopentyl)-1-propanone 
• 13561-57-4 3-Phenyl-4-nitro-1-(4-nitro-phenyl)-hexan-1-on 
• 39274-70-9 (E)-1-(4-nitrophenyl)-3-phenylprop-2-en-1-ol 
• 1256449-78-1 thioacetic acid S-[3-(4-nitrophenyl)-3-oxo-1-phenyl-propyl] ester 

Relevant articles and documents

Synthesis and anti-inflammatory activity of three nitro chalcones

The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2 h. The three structures were evaluated on biological activity at dose of 200 mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.

Recyclable Copper Nanoparticles-Catalyzed Hydroboration of Alkenes and β-Borylation of α,β-Unsaturated Carbonyl Compounds with Bis(Pinacolato)Diboron

Nano-ferrite-supported Cu nanoparticles (Fe-dopamine-Cu NPs) catalyzed anti-Markovnikov-selective hydroboration of alkenes with B2pin2 is reported under mild reaction conditions. This protocol can be applied to a broad range of substrates with high functional group compatibility. In addition, we demonstrated the use of Fe-dopamine-Cu NPs as a catalyst for the β-borylation of α,β-unsaturated ketones and ester, providing alkylboronate esters in up to 98% yield. Reuse of the magnetically recyclable catalyst resulted in no significant loss of activity in up to five reaction runs for both systems. (Figure presented.).

Boosting the catalytic performance of zinc linked amino acid complex as an eco-friendly for synthesis of novel pyrimidines in aqueous medium

Zinc linked amino acid complex, Zn(l-proline)2, is considered as a green catalyst for the synthesis of novel series of pyrimidine derivatives 5a–q. The pyrimidines 5a–q were prepared via two pathways: the first is a one-pot reaction of guanidines 3a–c with aromatic aldehyde 1 and acetophenones 2; and the second one is the reaction of guanidines 3a–c with different chalcones 4a–j in aqueous medium. The simplicity of the operation, the short reaction time, and the high efficiency (97%) are the main advantages of this protocol. Furthermore, the green aspects of this synthetic protocol were further investigated by examining the reusability of Zn(l-proline)2 complex throughout five consecutive cycles without a significant loss of catalytic activity. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, a short reaction time, excellent yields, and high purities without using any organic solvents.