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Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 20443-03-2 Structure
  • Basic information

    1. Product Name: Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate
    2. Synonyms: Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate
    3. CAS NO:20443-03-2
    4. Molecular Formula: C9H9NO5
    5. Molecular Weight: 211.17146
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 20443-03-2.mol
  • Chemical Properties

    1. Melting Point: 169-169.5 °C(Solv: methanol (67-56-1))
    2. Boiling Point: 349.0±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.346±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 5.77±0.69(Predicted)
    10. CAS DataBase Reference: Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate(20443-03-2)
    12. EPA Substance Registry System: Dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate(20443-03-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 20443-03-2(Hazardous Substances Data)

20443-03-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 20443-03-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,4 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20443-03:
(7*2)+(6*0)+(5*4)+(4*4)+(3*3)+(2*0)+(1*3)=62
62 % 10 = 2
So 20443-03-2 is a valid CAS Registry Number.

20443-03-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester

1.2 Other means of identification

Product number -
Other names chelidamic acid dimethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20443-03-2 SDS

20443-03-2Relevant articles and documents

Synthetic Approaches to the Bifunctional Chelators for Radio nuclides Based on Pyridine-Containing Azacrown Compounds

Fedorova, Olga A.,Shchukina, Anna A.,Zubenko, Anastasia D.

, p. 1087 - 1095 (2020)

Synthetic ways to introduce functional groups (CO 2 Me, CO 2 H, OCH 2 CO 2 H, OCH 2 C≡CH, CH 2 OH, CH 2 Cl, CH 2 N 3) into the pyridine ring of pyridine-containing azacrown compounds are described. These groups were introduced at position-4 of the pyridine ring, while keeping the macrocyclic carboxylate groups available for metal chelation. The derivatives were obtained by macrocyclization reaction of 4-substituted, trimethyl pyridine-2,4,6-tricarboxylate or by modification of methyl ester group in pyridine fragment of macrocycles. Obtained derivatives can be applied for preparing radiotherapeutic agents by conjugation to different vector biomolecules for targeted drug delivery to cancer cells without damaging healthy tissue.

Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis

Chen, Shuo-Bin,Chen, Xiu-Cai,Dai, Jing,Huang, Zhi-Shu,Luo, Wen-Hua,Shao, Wen,Tan, Jia-Heng,Tang, Gui-Xue,Zeng, Shu-Tang

supporting information, p. 20779 - 20791 (2021/12/14)

The mitochondrial DNA G-quadruplex (mtDNA G4) is a potential regulatory element for the regulation of mitochondrial functions; however, its relevance and specific roles in diseases remain largely unknown. Here, we engineered a set of chemical probes, incl

Picolinamide oligomers, preparation method and applications thereof

-

Paragraph 0024; 0047; 0050, (2018/08/28)

The invention belongs to the technical field of membrane separation, and more specifically relates to picolinamide oligomers, a preparation method and applications thereof. The picolinamide oligomerscomprise the following characteristics: 1. the oligomers

The assembly of "s3N"-ligands decorated with an azo-dye as potential sensors for heavy metal ions

Rasheed,McDouall,Muryn,Raftery,Vitorica-Yrezabal,Quayle

, p. 5229 - 5239 (2017/04/27)

An "S3N-ligand azo-dye" conjugate has been synthesised with a view to the development of a sensor for heavy metal ions. Complexation of this system with Ag(i), Hg(ii) and Cu(ii) salts has been investigated and an X-ray structure has been obtained for a Hg(ii) complex. Complexation of the conjugated dye to these metals results in a bathochromic shift in the absorption maximum of the azo dye, an effect which is most pronounced for Cu(ii).

The Synthesis of Group 10 and 11 Metal Complexes of 3,6,9-Trithia-1-(2,6)-pyridinacyclodecaphane and Their Use in A3-Coupling Reactions

Rasheed, Omer K.,Bawn, Carlo,Davies, David,Raftery, James,Vitorica-Yrzebal, I?igo,Pritchard, Robin,Zhou, Huimin,Quayle, Peter

, p. 5252 - 5261 (2017/09/29)

The reaction between 3,6,9-trithia-1(2,6)-pyridinacyclodecaphane and representative group 10 and 11 metal salts [Cu(NO3)2, NiCl2 or Ag(CF3CO2)] afforded 1:1 complexes, which in the case of CuII and AgI were characterised by single-crystal X-ray crystallography. The catalytic activity of these complexes in A3-coupling reactions between aldehydes, terminal alkynes and amines was assessed in both protic (water) and aprotic (toluene) media. These A3-reactions prove to be more efficient, proceed with lower catalyst loadings and with faster reaction rates, when conducted in a focused microwave reactor as compared to the same reactions promoted by standard, thermal, modes of activation.

Pyridostatin compound and its preparation method and application

-

Paragraph 0037-0040, (2016/10/09)

The invention provides Pyridostatin compounds, and a preparation method and application thereof. The structural formula of the Pyridostatin compounds is disclosed as Formula I. The compounds and pharmaceutically acceptable salts thereof have favorable antitumor activity for human lung cancer and human colon cancer.

Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog

Feng, Yun,Yang, Dazhang,Chen, Hongbo,Cheng, Wenli,Wang, Lixia,Sun, Hongxia,Tang, Yalin

supporting information, p. 1660 - 1663 (2016/07/27)

The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer.

Pyridostatins selectively recognize two different forms of the human telomeric G-quadruplex structures and their anti-tumor activities in vitro

Wang, Li-Xia,Shang, Qian,Li, Qian,Xiang, Jun-Feng,Liu, Yan,Guan, Ai-Jiao,Sun, Hong-Xia,Yu, Li-Jia,Tang, Ya-Lin

supporting information, p. 4982 - 4986 (2015/06/23)

G-quadruplex as a therapeutic target to develop novel anti-cancer agents has attracted a growing interest. Among all the ligands of G-quadruplexes, pyridostatin derivatives play a very important role. Here, we first reported the recognition of the fundamental skeleton pyridostatin I, which was simply synthesized. Compared to pyridostatin II comprising terminal amino groups, pyridostatin I selectively stabilized intramolecular anti-parallel telomeric G-quadruplex by raising the melting temperature about 20 °C at 295 nm of H22, while pyridostatin II preferred to stabilize intermolecular parallel telomeric G-quadruplex by raising the melting temperature about 25 °C at 265 nm of H7, maybe due to the suited size measurements between G-quadruplex hosts and pyridostatin guests. MTT assays indicated that pyridostatin II had better cytotoxic effects against HCT-8 and A549 cell lines obviously, indicating positively charged side chains may be required for improving the water solubility and cellular uptake of the apolar central skeleton.

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position

Hamada, Yoshio,Suzuki, Kenji,Nakanishi, Tomoya,Sarma, Diganta,Ohta, Hiroko,Yamaguchi, Ryoji,Yamasaki, Moe,Hidaka, Koushi,Ishiura, Shoichi,Kiso, Yoshiaki

, p. 618 - 623 (2014/01/23)

We have previously reported potent substrate-based pentapeptidic BACE1 inhibitors possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic. While these inhibitors exhibited potent activities in enzymatic and cellular assays (KMI-4

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres

Rodriguez, Raphael,Mueller, Sebastian,Yeoman, Justin A.,Trentesaux, Chantal,Riou, Jean-Francois,Balasubramanian, Shankar

supporting information; experimental part, p. 15758 - 15759 (2009/05/15)

We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. We report that this compound can be used in vitro to inhibit telomerase activity and to uncap human POT1 (protection of telomeres 1) from the telomeric G-overhang. We also show that the small molecule G-quadruplex binder induces a partial alteration of shelterin through POT1 uncapping from telomeres in human HT1080 cancer cells and the presence of γH2AX foci colocalized at telomeres. Copyright

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