20570-96-1

Basic information

• Product Name: BENZYLHYDRAZINE DIHYDROCHLORIDE
• Synonyms: BENZYL HYDRAZINE DI HCL;BENZYLHYDRAZINE DIHYDROCHLORIDE;benzyl-hydrazindihydrochloride;Benzylhydrazine2HCl;Hydrazine, benzyl, dihydrochloride.;BZHDH;Benzylhydrazine dihydrochloride,97%;BENZYLHYDRAZINE DIHY
• CAS NO: 20570-96-1
• Molecular Formula: C₇H₁₀N₂*ClH
• Molecular Weight: 195.09
• EINECS: 243-887-1
• Product Categories: Hydrazines;Nitrogen Compounds;Organic Building Blocks;Pharmaceutical intermediate
• Mol File: 20570-96-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 143-145 °C (dec.)(lit.)
• Boiling Point: 265.4 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: Slightly yellow to beige/Powder
• Density: 0.628g/cm3 at 23℃
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 3688990
• CAS DataBase Reference: BENZYLHYDRAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYLHYDRAZINE DIHYDROCHLORIDE(20570-96-1)
• EPA Substance Registry System: BENZYLHYDRAZINE DIHYDROCHLORIDE(20570-96-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MU8540000
• F: 10
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 20570-96-1(Hazardous Substances Data)

Usage

Uses

Benzylhydrazine dihydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Safety Profile

Poison by intraperitoneal route.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits very toxicfumes of HCl and NOx.

Upstream product

• 561067-10-5 N-benzyl-N'-isopropylidene-hydrazinecarboxylic acid tert-butyl ester 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 100-52-7 benzaldehyde 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 100-51-6 benzyl alcohol 
• 287729-00-4 N-benzyl-N-tert-butyloxycarbonylaminophthalimide 
• 185456-43-3 N-benzyl-N’-[(tert-butoxy)carbonyl](tert-butoxy)carbohydrazide 
• 147688-34-4 tert-butyl 1-benzylhydrazine-1-carboxylate 
• 13211-11-5 benzaldehyde benzylhydrazone 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 93019-54-6 1-Ethansulfonyl-1-benzyl-2-benzyliden-hydrazin 
• 81468-07-7 3-(3-benzyl-thiocarbazoyl-thio)-propionsaeure 
• 80465-12-9 1-benzyl-3,5-diphenyl-1H-1,2,4-triazole 
• 143706-70-1 1-(phenylmethyl)-5-(trifluoromethyl)-1H-pyrazol-3-ol 
• 143706-79-0 1-(phenylmethyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol 
• 152713-70-7 2-Benzyl-5-butyl-4-(2'-cyano-biphenyl-4-ylmethyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 115310-15-1 2-<(2-(phenylmethyl)hydrazino)methylene>-1,3-cyclopentanedione 
• 132960-22-6 tert-butyl 3,4-dihydro-4-oxo-3-benzyl-1-phthalazineacetate 
• 134390-10-6 1-phenyl-2-(phenylmethyl)phthalazinium chloride 
• 87289-87-0 1-benzylhexahydro-1,2,4-triazine-3,6-dione 
• 160712-05-0 Acetic acid (S)-3-((R)-1-benzyl-5-oxo-pyrazolidin-3-yl)-2-hydroxy-propyl ester 
• 196504-90-2 5-amino-1-benzyl-3-phenyl-1H-pyrazole-4-carbonitrile 
• 303066-82-2 ethyl 5-amino-1-benzyl-3-methyl-1H-pyrazole-4-carboxylate 
• 19867-62-0 ethyl 5-amino-1-benzyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides

A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C?N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C?N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono-amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures.

Simple preparation of monoalkylhydrazines

Alkylation of t-butyl isopropylidene carbazate with alkyl bromides occurs under phase-transfer conditions. Acid hydrolysis of the product completes a simple two-step synthesis of monoalkylhydrazines.

N-tert-butoxycarbonylaminophthalimide, a versatile reagent for the conversion of alcohols into alkylated tert-butylcarbazates or hydrazines via the Mitsunobu protocol

An efficient two-step method has been developed for the conversion of alcohols to substituted hydrazines. The use of N-tert- butoxycarbonylaminophthalimide as an acid partner in Mitsunobu reactions with a variety of alcohols permits the synthesis of the corresponding monoalkylated tert-butylcarbazates and hydrazines.