196504-90-2

Upstream product

• 18440-50-1 N-benzyl-N'-benzylidene-4-methylbenzenesulfonohydrazide 
• 109-77-3 malononitrile 
• 2168-78-7 methyl dithiobenzoate 
• 13846-64-5 2-Cyano-3-methylthio-3-phenylacrylonitrile 
• 20570-96-1 benzylhydrazine dihydrochloride 

Downstream Products

• 196505-04-1 1-Benzyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol 
• 196505-09-6 (1-Benzyl-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(3-chloro-phenyl)-amine 
• 196505-06-3 1-Benzyl-4-chloro-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Preparation method of 5-amino-4-cyanopyrazole

The invention belongs to the field of organic chemistry, relates to a preparation method of 5-amino-4-cyanopyrazole, and discloses a preparation method of 5-amino-4-cyanopyrazole. According to the invention, a series of 5-amino-4-cyanopyrazole are prepare

Regioselective Synthesis of Highly Functionalized Pyrazoles from N-Tosylhydrazones

A regioselective synthesis of highly functionalized pyrazoles from N-tosylhydrazones was developed. The reaction was general for a wide range of substrates and demonstrated excellent tolerance to a variety of substituents, and the method has been successfully applied to the formal synthesis of ibrutinib.

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w