28867-76-7Relevant articles and documents
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Kametani et al.
, p. 1678 (1960)
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Scheppele et al.
, p. 557 (1970)
Liquid chromatographic determination of hydrazine at sub-parts-per-million levels in workroom air as benzaldazine with the use of chemosorption on benzaldehyde-coated amberlite XAD-2
Andersson,Hallgren,Levin,Nilsson
, p. 1730 - 1731 (1984)
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General and Greener Synthesis of Diverse Functional Organic Salts through Schiff Base Chemistry
Hu, Baoping,Shi, Qingrong,Lu, Feipeng,Zhang, Pengcheng,Peng, Panpan,Zhao, Chaofeng,Du, Yao,Su, Hui,Li, Shenghua,Pang, Siping,Nie, Fudie
, p. 910 - 918 (2019)
We report a greener and more-general organic method for the synthesis of functional organic salts containing organic anions through a Schiff base reaction between readily available aldehydes and simple aminoguanidinium salts. This reaction is operationally simple, free of metal salts, and forms water as the sole byproduct. The broad scope and good functional-group compatibility of this method permit its use to provide ready access to a library of more than 70 distinct organic salts, including those of heterocyclic anions, complex pharmaceutical anions, and polyanions, which are difficult to obtain through classical inorganic methods. Moreover, choosing different aldehydes and organic anions provides a convenient method for modulating or improving the functional properties of the designed organic salts, such as their melting points, fluorescence, and energetic properties. We therefore expect that this method will open new opportunities for the discovery and functionalization of a wide variety of organic salts and functional materials.
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
, p. 624 - 634 (2020/11/30)
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
Dihydrazone-based dynamic covalent epoxy networks with high creep resistance, controlled degradability, and intrinsic antibacterial properties from bioresources
Feng, Jie,Li, Qiong,Liu, Yanlin,Lu, Na,Ma, Songqi,Wang, Sheng,Wu, Jiahui,Xu, Xiwei,Yang, Jintao,Zhu, Jin
, p. 11261 - 11274 (2020/06/17)
Covalent adaptable networks (CANs) provide a promising approach to solve the issue of recycling thermosets due to their dynamic cross-linked networks. However, CANs are susceptible to creep at relatively low temperatures, and their chemical stability is also inevitably doubtful. Here, we designed novel dihydrazone CANs by cross-linking a dihydrazone-containing epoxy monomer, which was synthesized from the condensation of a lignin derivative vanillin and hydrazinium hydrate, followed by a reaction with epichlorohydrin. Besides the excellent malleability and reprocessability, the dihydrazone CANs exhibited a high initial creep temperature of ～105 °C, which was ascribed to the superior stability of the hydrazone bond at around 100 °C and favorable hydrazone exchangeability at elevated temperatures. Meanwhile, the degradation of the dihydrazone CANs exhibited temperature, solvent, and acidity dependence. Moreover, on account of the high antibacterial properties of the hydrazone bond, the CANs presented a high killing rate (95.8%) for Gram-negative bacteria (E. coli). Thus, this work discloses an effective dynamic covalent motif for the development of CANs with excellent dimensional stability, chemical resistance, and intrinsic antibacterial properties.
