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Z-SER(BZL)-OH is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

20806-43-3

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20806-43-3 Usage

Uses

Cbz-Ser(Bzl)-OH is used in preparation of Aminoamide derivatives as anticancer agents.

Check Digit Verification of cas no

The CAS Registry Mumber 20806-43-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,8,0 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20806-43:
(7*2)+(6*0)+(5*8)+(4*0)+(3*6)+(2*4)+(1*3)=83
83 % 10 = 3
So 20806-43-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H19NO5/c20-17(21)16(13-23-11-14-7-3-1-4-8-14)19-18(22)24-12-15-9-5-2-6-10-15/h1-10,16H,11-13H2,(H,19,22)(H,20,21)/t16-/m0/s1

20806-43-3 Well-known Company Product Price

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  • Alfa Aesar

  • (H62748)  N-Benzyloxycarbonyl-O-benzyl-L-serine, 95%   

  • 20806-43-3

  • 250mg

  • 403.0CNY

  • Detail
  • Alfa Aesar

  • (H62748)  N-Benzyloxycarbonyl-O-benzyl-L-serine, 95%   

  • 20806-43-3

  • 1g

  • 1176.0CNY

  • Detail
  • Alfa Aesar

  • (H62748)  N-Benzyloxycarbonyl-O-benzyl-L-serine, 95%   

  • 20806-43-3

  • 5g

  • 5460.0CNY

  • Detail

20806-43-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-3-phenylmethoxy-2-(phenylmethoxycarbonylamino)propanoic acid

1.2 Other means of identification

Product number -
Other names Cbz-Ser(Bzl)-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20806-43-3 SDS

20806-43-3Relevant articles and documents

A new method for formacetal linkage formation: Protection of alcohols, phenols and carboxylic acids

Sawada, Daisuke,Ito, Yukishige

, p. 2501 - 2504 (2001)

A new formacetal linkage (ROCH2OR′) forming reaction was developed, which exploited a combination of sulfide (R′OCH2SR″) and CuBr2-Bu4NBr. This reaction proceeded to give high yields under neutral conditions and was applied to the protection of alcohols, phenols and carboxylic acids by several types of α-oxymethyl groups.

METHOD FOR PRODUCING CARBOXYLIC ACID AND ALCOHOL BY HYDROLYSIS OF ESTER

-

Paragraph 0069; 0070, (2014/11/13)

As shown by the following formula (1), after methyl laurate (2 mmol) and water (8 mL) are added to an ammonium pyrosulfate catalyst (5 mol%), a hydrolysis reaction of methyl laurate is carried out by heating for 24 hours at 60°C while stirring is performed, so that lauric acid can be obtained with a yield of 86%.

N,N-diarylammonium pyrosulfate as a highly effective reverse micelle-type catalyst for hydrolysis of esters

Koshikari, Yoshiki,Sakakura, Akira,Ishihara, Kazuaki

experimental part, p. 3194 - 3197 (2012/07/31)

Reverse micelle-type N,N-diarylammonium pyrosulfate (3-5 mol %) efficiently catalyzes the hydrolysis of esters (up to 100 mmol scale) under organic solvent-free conditions. The present method is successfully applied to the hydrolysis of various esters without the decomposition of the base-sensitive moieties and without any loss of optical purity for α-heterosubstituted carboxylic acids.

A stereocontrolled synthesis of a new class of 3,4,5,6- tetrahydropyrimidine-based chiral amino acids

Zamri, Adel,Sirockin, Finton,Abdallah, Mohamed A.

, p. 5157 - 5170 (2007/10/03)

The stereocontrolled synthesis of seven 2-substituted-4-carboxy-3,4,5,6- tetrahydropyrimidines bearing either one chiral center at C-4 or two chiral centers at C-4 and C-8 was performed by condensation of (S)- or (R)- 2,4- diaminobutyric acid (Daba) with iminoethers derived from glycine, (S)- and (R)- serine, (S)- and (R)- tyrosine. Under the conditions reported, epimerization was always completely prevented at the C-4 center, whereas at the C-8 center, it was completely avoided in the case of tyrosine derivatives and considerably diminished for the serine derivatives.

6-Amino-2,4-lutidine carboxamides: α-aminoamide derivatives as systemic and topical inflammation inhibitors

Duflos, Muriel,Courant, Jacqueline,Le Baut, Guillaume,Grimaud, Nicole,Renard, Pierre,Manechez, Dominique,Caignard, Daniel-Henri

, p. 635 - 645 (2007/10/03)

The development of new potential anti-inflammatory compounds resulting from the incorporation of α-aminoacid residues into 6-amino-2,4-lutidine afforded (N-protected) aminoamides with interesting inhibitory activity. Out of 28 tested compounds, 10 (5a, 5b, 7d, 8a, 8b, 8d, 10a, 11b, 12a and 12b) exerted potent (> 90%) inhibition in the carrageenan foot edema (CFE) rat model after oral administration or 0.4 mmol kg-1. Except for Cbz-glycyl, Cbz-alanyl, Fmoc-valyl and Cbz-alanyl-glycyl derivatives (5a, 5b, 7d and 11b), N-deprotection afforded more active compounds. Introduction of a glycyl residue in the previously studied highly active 3-fluorobenzamide 2, which led to 10a, maintained potent peripheral edema inhibition but had a detrimental effect in the acute TPA-induced mouse ear-swelling model. Glycylglycinamide 12a, which had an ID50 of 9.0 mg kg-1 in the CFE test, appeared to be the most efficient compound tested in this new series of non-carboxylic nonsteroidal anti-inflammatory drugs. Glycinamide 8a, although less potent in the same assay (14.3 mg kg-1), exerted a significant inhihitory effect in acute and chronic ear-swelling tests after topical application of 3 mg/ear.

A Stereoselective Synthesis of threo-3-Hydroxyglutamic Acid

Dell'Uomo, Natalina,Giovanni, Maria C. Di,Misiti, Domenico,Zappia, Giovanni,Monache, Giuliano Delle

, p. 641 - 644 (2007/10/02)

The highly stereoselective iodocyclocarbamation of the chiral Z olefins 6 and 12, derived from the corresponding α-amino acid, yields threo-3-hydroxy-D- and -L-glutamic acid (1 and 2). - Key Words: Amino acids / Glutamic acids / Serine / Iodocyclocarbamation

Improved efficiency and selectivity in peptide synthesis: Use of triethylsilane as a carbocation scavenger in deprotection of t-butyl esters and t-butoxycarbonyl-protected sites

Mehta, Anita,Jaouhari, Rabih,Benson, Timothy J.,Douglas, Kenneth T.

, p. 5441 - 5444 (2007/10/02)

The use of triethylsilane as a carbocation scavenger in the presence of trifluoroacetic acid in dichloromethane leads to increased yields, decreased reaction times, simple work-up and improved selectivity for the deprotection of t-butyl ester and t-butoxycarbonyl sites in protected amino-acids and peptides in the presence of other acid-sensitive protecting groups such as the benzyloxycarbonyl, 9-fluorenylmethoxycarbonyl, O- and S-benzyl and t-butylthio groups.

GLUTARAMIDE DIURETIC AGENTS

-

, (2008/06/13)

A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5-or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.

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