2167-14-8

Basic information

• Product Name: 1-Ethyl-1H-pyrrole-2-carbaldehyde
• Synonyms: 1-Ethyl-1H-pyrrole-2-carbaldehyde;1-Ethyl-1H-pyrrole-2-carboxaldehyde;1-ethyl-1H-pyrrole-2-carbaldehyde (SALTDATA: FREE);1-ETHYL-2-PYRROLECARBOXALDEHYDE
• CAS NO: 2167-14-8
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• Mol File: 2167-14-8.mol

Chemical Properties

• Boiling Point: 59 °C(Press: 6 Torr)
• Appearance: /
• Density: 0.99±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -6.88±0.70(Predicted)
• Stability: Moisture Sensitive
• CAS DataBase Reference: 1-Ethyl-1H-pyrrole-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-1H-pyrrole-2-carbaldehyde(2167-14-8)
• EPA Substance Registry System: 1-Ethyl-1H-pyrrole-2-carbaldehyde(2167-14-8)

Safety Data

• Hazardous Substances Data: 2167-14-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethyl-1H-pyrrole-2-carbaldehyde is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable component in the development of new drugs and medicinal agents.
Used in Chemical Industry:
In the chemical industry, 1-Ethyl-1H-pyrrole-2-carbaldehyde is utilized as a building block for the synthesis of a range of chemical products. Its versatility and reactivity contribute to the creation of diverse chemical entities for various applications.

Upstream product

• 617-92-5 1-ethyl-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 1192-58-1 N-methylpyrrole aldehyde 
• 74-88-4 methyl iodide 
• 1003-29-8 2-pyrrole aldehyde 
• 78-40-0 triethyl phosphate 
• 400715-78-8 1-(2-Bromoethyl)-1H-pyrrole-2-carbaldehyde 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 98-01-1 furfural 
• 1708-41-4 2-(furan-2-yl)-1,3-dioxolane 
• 20948-40-7 methyl 3-(2-formyl-1H-pyrrol-1-yl)propanoate 
• 90005-94-0 3-(2-formyl-1H-pyrrol-1-yl)propanoic acid 
• 400715-57-3 phenyl 3-(2-formyl-1H-pyrrol-1-yl)propaneselenoate 

Downstream Products

• 1590409-43-0 C₁₆H₁₃F₃N₂O₂ 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 

Relevant articles and documents

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The invention relates to a preparation method for N-ethyl-2-aminomethylpyrrolidine. The preparation method comprises the following steps: with furfural as a raw material, subjecting the furfural to acetal protection so as to obtain furfural glycol acetal, allowing the furfural glycol acetal to react with ethylamine so as to generate 2-(1,3-dioxolan-2-yl)-N-ethylpyrrole, allowing the 2-(1,3-dioxolan-2-yl)-N-ethylpyrrole to react with diluted hydrochloric acid so as to generate N-ethylpyrrole-2-carbaldehyde, and subjecting the N-ethylpyrrole-2-carbaldehyde and liquid ammonia to palladium-carbonreductive ammoniation by one step so as to generate the N-ethyl-2-aminomethylpyrrolidine. The preparation method has a synthetic route which is described in the specification. The invention has the following advantages: the preparation method for the N-ethyl-2-aminomethylpyrrolidine provided by the invention starts with the furfural as a raw material to prepare a product through protection, amination and reductive ammoniation, and has the advantages of short reaction route, high yield capable of reaching 85% or above, little pollution and applicability to industrialization.

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