217813-00-8

Basic information

• Product Name: 4,5-difluoro-2-(trimethylsilyl)phenyl triflate
• CAS NO: 217813-00-8
• Molecular Formula: C₁₀H₁₁F₅O₃SSi
• Molecular Weight: 334.33500
• Mol File: 217813-00-8.mol

Chemical Properties

• CAS DataBase Reference: 4,5-difluoro-2-(trimethylsilyl)phenyl triflate(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-difluoro-2-(trimethylsilyl)phenyl triflate(217813-00-8)
• EPA Substance Registry System: 4,5-difluoro-2-(trimethylsilyl)phenyl triflate(217813-00-8)

Safety Data

• Hazardous Substances Data: 217813-00-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is used as a reagent for its powerful electrophilic nature in various organic synthesis processes. It facilitates reactions such as nucleophilic substitution, where it can be replaced by a nucleophile, and palladium-catalyzed coupling reactions, which are crucial for forming carbon-carbon bonds in complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate is utilized as a key intermediate in the synthesis of complex drug molecules. Its unique combination of difluoro and trimethylsilyl groups allows for the creation of novel pharmaceutical compounds with potential therapeutic applications.
Used in Fluorination Reactions:
4,5-difluoro-2-(trimethylsilyl)phenyl triflate is employed as a fluorinating agent in chemical reactions where the introduction of fluorine atoms is required. The presence of the difluoro groups makes it particularly useful for fluorination processes, which are important for enhancing the properties of organic compounds, including their reactivity, stability, and lipophilicity.
Used in Research and Development:
In research and development settings, 4,5-difluoro-2-(trimethylsilyl)phenyl triflate is used as a tool to explore new chemical reactions and mechanisms. Its unique properties allow chemists to investigate novel pathways and develop innovative synthetic strategies for the creation of new organic compounds and materials.

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 166281-37-4 2-bromo-4,5-difluorophenol 
• 232611-13-1 (2-bromo-4,5-difluoro-phenoxy)-trimethyl-silane 
• 232611-14-2 1,2-difluoro-4-trimethylsilanyl-5-trimethylsilanyloxy-benzene 

Downstream Products

• 951773-63-0 1-(4,5-difluoro-2-styrylphenyl)pentan-3-one 
• 1129543-62-9 (E)-4-(4,5-difluoro-2-(hex-1-ynyl)phenyl)but-2-en-1-ol 
• 1430214-82-6 diethyl (3,4-difluorophenyl)phosphonate 
• 1430214-83-7 dimethyl 3,4-difluorophenylphosphonate 
• 223444-29-9 N-(tert-butyl)-3,4-difluorobenzamide 
• 1612231-95-4 1-benzyl-6,7-difluoro-4-(methylthio)-3-(4-nitrophenyl)quinolin-2(1H)-one 
• 1612232-27-5 (Z)-N-benzyl-3-(3,4-difluorophenylthio)-3-(methylthio)-2-(4-nitrophenyl)acrylamide 
• 1612232-28-6 (E)-N-benzyl-3-(3,4-difluorophenylthio)-3-(methylthio)-2-(4-nitrophenyl)acrylamide 
• 1612231-96-5 3-benzoyl-1-benzyl-6,7-difluoro-4-(methylthio)quinolin-2(1H)-one 
• 1595288-07-5 2-(cyano(dimethylamino)methyl)-4,5-difluorophenyl benzoate 
• 1507400-76-1 2-[(4-bromophenyl)amino]-4,5-difluorobenzonitrile 
• 1447034-87-8 4-(benzyl(3,4-difluorophenyl)amino)-3-phenylbutanenitrile 

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