2214-53-1

Basic information

• Product Name: 4-CYANO-2-METHYLPYRIDINE
• Synonyms: 4-CYANO-2-METHYLPYRIDINE;2-METHYL-4-CYANOPYRIDINE;4-CYANO-2-PICOLINE;2-Methyl-isonicotinonitrile;2-Methyl-4-pyridinecarbonitrile;2-cyano-2-Methyl-1,2-dihydropyridine-4-carboxylic acid;4-Pyridinecarbonitrile,2-Methyl-
• CAS NO: 2214-53-1
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.13594
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Pyridines;Aromatics;Heterocycles;Intermediates
• Mol File: 2214-53-1.mol

Chemical Properties

• Melting Point: NA
• Boiling Point: 213℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.08
• Vapor Pressure: 0.17mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: 4-CYANO-2-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-2-METHYLPYRIDINE(2214-53-1)
• EPA Substance Registry System: 4-CYANO-2-METHYLPYRIDINE(2214-53-1)

Safety Data

• Hazardous Substances Data: 2214-53-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-CYANO-2-METHYLPYRIDINE is used as an intermediate for the synthesis of calcium antagonists, which are medications that help in the treatment of various cardiovascular conditions such as hypertension, angina, and arrhythmias. Its chemical properties make it a suitable candidate for the development of these therapeutic agents.

InChI:InChI=1/C7H6N2/c1-6-4-7(5-8)2-3-9-6/h2-4H,1H3

Upstream product

• 19354-04-2 2-methyl-isonicotinic acid amide 
• 151-50-8 potassium cyanide 
• 92304-51-3 N-Methoxy-2-picolinium iodide 
• 143-33-9 sodium cyanide 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 4021-11-8 2-methylisonicotinic acid 

Downstream Products

• 94413-70-4 1-(2-methylpyridin-4-yl)methanamine 
• 4021-11-8 2-methylisonicotinic acid 
• 3390-77-0 2-methyl-thioisonicotinic acid amide 
• 98549-84-9 4-Cyano-2-picoline-N-oxide 
• 100383-05-9 2-methyl-1-oxy-isonicotinic acid amide 
• 63875-01-4 2-methyl-pyridine-4-carbaldehyde 
• 659725-71-0 4,6-dichloro-5-(2-methoxy-phenoxy)-2-(2-methyl-pyridin-4-yl)-pyrimidine 
• 659725-69-6 5-(2-methoxy-phenoxy)-2-(2-methyl-pyridin-4-yl)-pyrimidine-4,6-diol 
• 370105-35-4 4,6-dichloro-5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-pyrimidine 
• 370105-91-2 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-pyrimidin-4-yl]-amide 
• 370105-36-5 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-pyrimidin-4-yl]-amide 
• 370105-74-1 4-tert-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-pyrimidin-4-yl]-benzenesulfonamide 
• 370567-30-9 5-isopropyl-pyridine-2-sulfonic acid [5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-6-prop-2-ynyloxy-pyrimidin-4-yl]-amide 
• 370567-28-5 4-tert-butyl-N-[5-(2-methoxy-phenoxy)-2-(2-methyl-1-oxy-pyridin-4-yl)-6-prop-2-ynyloxy-pyrimidin-4-yl]-benzenesulfonamide 

Relevant articles and documents

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.

Volatile compounds formed from the pyrolysis of chitosan

Chitosan is a renewable resource for the production of nitrogen-containing aromatic heterocyclics. It was found that chitosan started to decompose and produce some volatile compounds at around 525 K in a nitrogen atmosphere, the volatiles were characterized by Fourier transform infrared spectrometer. The apparent activation energy for the thermal degradation of chitosan was determined. To further investigate the degradation, chitosan was pyrolyzed under vacuum at 553 K for 1 h, and the volatile compounds were analyzed by gas chromatography/mass spectrometry. The volatile compounds included aromatic heterocyclics such as pyrazines, pyridines, pyrroles and furans, and the pyrazines were the major products. The pyrolysis mechanism of chitosan was also proposed.

PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS

The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituants are as defined in the claims.

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula I.