22347-47-3

Basic information

• Product Name: 1,4-Dioxan-2-ol
• CAS NO: 22347-47-3
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Mol File: 22347-47-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1,4-Dioxan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxan-2-ol(22347-47-3)
• EPA Substance Registry System: 1,4-Dioxan-2-ol(22347-47-3)

Safety Data

• Hazardous Substances Data: 22347-47-3(Hazardous Substances Data)

Usage

General Description

1,4-Dioxan-2-ol, also known as p-dioxane-2-ol, is a colorless liquid with a mild, pleasant odor. It is a stabilizer and solvent commonly used in the manufacture of pharmaceuticals, dyes, and organic synthesis. 1,4-Dioxan-2-ol is also used as a solvent for cellulose esters, resins, waxes, and oils. It is considered to be a moderately hazardous chemical, with potential harmful effects on the respiratory system and skin irritation. Additionally, 1,4-Dioxan-2-ol is classified as a potential environmental hazard due to its toxicity to aquatic organisms. Despite its potential hazards, this compound has various applications in the chemical industry and is widely used in the production of a range of consumer products.

Upstream product

• 62005-55-4 2-(2,2-diethoxyethoxy)ethan-1-ol 
• 23125-71-5 2-chloro-1,4-dioxacyclohexene 
• 123-91-1 1,4-dioxane 
• 111-46-6 diethylene glycol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 4598-47-4 dioxanyl radical 
• 100-34-5 benzene diazonium chloride 

Downstream Products

• 4076-31-7 2-[2-(4-methylpiperazin-1-yl)ethoxy]ethanol 
• 1219592-80-9 2-(2-((3-fluorophenyl)amino)ethoxy)ethan-1-ol 
• 1219592-82-1 2-{2-[(2-chlorophenyl)amino]ethoxy}ethanol 
• 1219592-84-3 ethyl 7-chloro-1-cyclopropyl-6-[2-(2-hydroxyethoxy)ethylamino]-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 190330-64-4 2‐[2‐(benzylamino)ethoxy]ethanol 
• 1219592-78-5 2-[2-(2-methyl-1-piperidyl)ethoxy]ethanol 
• 1184819-88-2 1,4-dioxane-2-yl-methacrylate 
• 61564-94-1 Ethyl-7-acetoxy-2-carbethoxy-5-oxa-2-heptenoat 

Relevant articles and documents

Au NPs@ polystyrene resin for mild and selective aerobic oxidation of 1,4 dioxane to 1,4 dioxan-2-ol

Supported gold nanoparticles of sizes 5–8 nm have been found as highly efficient catalyst for the oxidation of 1,4 dioxane, a saturated ether, using elemental oxygen at low temperature. GC–MS analysis of the reaction mixture showed > 85% conversion of 1,4 dioxane with a TON of 1120 h? 1 to 1,4 dioxan-2-ol with 90% selectivity. 1,4 Dioxan-2-one was obtained as the major byproduct along with traces of acetic acid and methoxy dioxalane. The catalyst displayed excellent stability and recyclability. TEM analysis of reused catalyst indicated that there was no significant change in the size, shape and morphology of gold nanoparticles.

Lignin-fueled photoelectrochemical platform for light-driven redox biotransformation

The valorization of lignin has significant potential in producing commodity chemicals and fuels from renewable resources. However, the catalytic degradation of lignin is kinetically challenging and often requires noble metal catalysts to be used under harsh and toxic conditions. Here, we report the bias-free, solar reformation of lignin coupled with redox biotransformation in a tandem structure of a BiVO4 photoanode and perovskite photovoltaic. The tandem structure compensates for the potential gap between lignin oxidation and biocatalytic reduction through artificial Z-schematic absorption. We found that the BiVO4-catalyzed photoelectrochemical oxidation of lignin facilitated the fragmentation of higher molecular weight lignin into smaller carboxylated aliphatic and aromatic acids. Lignin oxidation induced photocurrent generation at the photoanode, which enabled efficient electroenzymatic reactions at the cathode. This study successfully demonstrates the oxidative valorization of lignin as well as biocatalytic reductions (e.g., CO2-to-formate and α-ketoglutarate-to-l-glutamate) in an unbiased biocatalytic PEC platform, which provides a new strategic approach for photo-biocatalysis using naturally abundant renewable resources.

Production of Hydroxy Acids: Selective Double Oxidation of Diols by Flavoprotein Alcohol Oxidase

Flavoprotein oxidases can catalyze oxidations of alcohols and amines by merely using molecular oxygen as the oxidant, making this class of enzymes appealing for biocatalysis. The FAD-containing (FAD=flavin adenine dinucleotide) alcohol oxidase from P. chrysosporium facilitated double and triple oxidations for a range of aliphatic diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. For example, diethylene glycol could be selectively and fully converted into 2-(2-hydroxyethoxy)acetic acid. Such a facile cofactor-independent biocatalytic route towards hydroxy acids opens up new avenues for the preparation of polyester building blocks.