226888-37-5

Basic information

• Product Name: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE
• Synonyms: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE;Methyl (4-fluoro-3-nitrophenyl)acetate
• CAS NO: 226888-37-5
• Molecular Formula: C₉H₈FNO₄
• Molecular Weight: 213.16
• Mol File: 226888-37-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(226888-37-5)
• EPA Substance Registry System: METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE(226888-37-5)

Safety Data

• Hazardous Substances Data: 226888-37-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical structure and properties.
Used in Agrochemical Industry:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used in the synthesis of various agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Fine Chemicals Production:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is used as an intermediate in the production of fine chemicals, playing a crucial role in creating high-quality specialty products.
Used in Research and Development:
METHYL 2-(4-FLUORO-3-NITROPHENYL)ACETATE is utilized in research and development settings to explore its potential applications and enhance the understanding of its chemical properties and behavior in various reactions.

Upstream product

• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 405-50-5 p-Fluorophenylacetic acid 
• 67-56-1 methanol 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 
• 400-94-2 4-fluoro-3-nitrobenzoyl chloride 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 949570-83-6 C₈H₄FN₃O₃ 
• 157662-77-6 2-(4-fluoro-3-nitrophenyl)acetonitrile 

Downstream Products

• 949570-69-8 methyl 4-chloro-2-(4-(2-methoxy-2-oxoethyl)-2-nitrophenoxy)benzoate 
• 1455471-80-3 ethyl 2-((4-(2-methoxy-2-oxoethyl)-2-nitrophenyl)thio)acetate 
• 1455471-87-0 methyl 2-((4-(2-methoxy-2-oxoethyl)-2-nitrophenyl)amino)acetate 
• 257632-77-2 methyl (3-amino-4-fluorophenyl)acetate 
• 226888-23-9 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-isopropoxy-4-methoxybenzyl)-3-phenylpropionamide 
• 226888-40-0 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide 
• 192508-40-0 2-(4-fluoro-3-nitrophenyl)-N-<(3-isopropoxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-41-1 2-(4-fluoro-3-nitrophenyl)-N-<(3-hydroxy-4-methoxy-benzylcarbamoyl)-methyl>acetamide 
• 192508-37-5 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid methyl ester 
• 192508-38-6 <2-(4-fluoro-3-nitrophenyl)-acetylamino>-acetic acid 
• 192508-36-4 2-(4-fluoro-3-nitrophenyl)acetic acid 

Relevant articles and documents

Preparation method of 3-nitro-4-fluorophenylacetate

The invention discloses a method for preparing 3-nitro-4-fluorophenylacetate by using a microreactor, and belongs to the technical field of organic matter synthesis, the microreactor comprises precooling modules and a mixing module, and the method specifically comprises the following steps: (1) preparing raw materials: preparing a mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and a nitric acid solution; (2) pre-cooling: cooling the pre-cooling modules and the mixing module to a reaction temperature in advance, and then respectively adding the mixed solution of 4-fluorophenylacetate and concentrated sulfuric acid and the nitric acid solution into different pre-cooling modules; (3) mixing: after the raw materials are pre-cooled, adding the pre-cooled raw materials into the mixing module for mixing reaction; and (4) performing quenching and post-processing. The method provided by the invention can effectively control the heat release problem of the nitration reaction, and is high in safety; and the 3-nitro-4-fluorophenylacetate can be prepared with high selectivity, the conversion rate of the 4-fluorophenylacetate can reach 98.4%, and the selectivity can reach99: 1.

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases such as chronic viral infection, chronic bacterial infections, cancer, sepsis or a neurological disorder.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

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Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1, 4]diazepin-11-one-based potent and selective Chk-1 inhibitors

A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-based design. Aided by protein X-ray crystallography, medicinal chemistry efforts led to the

NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS

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Isothiazole derivatives and their use as pesticides

A compound of formula (I), where A is optionally substituted alkylene, alkenylene, alkynylene, cycloalkylene, alkylenoxy, oxy(C1-6)alkylene, alkylenethio, thio(C1-6)alkylene, C1-6alkylenamino, amino(C1-6)alkylene, [C1-6alkyleneoxy(C1-6)alkylene], [C1-6alkylenethio(c1-6)alkylene], [1-6alkylenesulfinyl(c1-6)alkylene], [c1-6alkylenesulfonyl(C1-6)alkylenc] or [C1-6alkyleneamino(C1-6)alkylene]; provided that A is not CH2 or CH2O; B is N, N-oxide or CR8; Y is O, S or NR9; Z is O, S or NR10; and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 are specified radicals; compositions containing them; processes for making them; and their use as insecticides or fungicides.

Synthetic studies towards western and eastern macropolypeptide subunits of Kistamycin

The western subunit (fused bicyclic 16+15 membered ring) was synthesized by sequential intramolecular S(N)Ar reaction and the first 17-membered ring compound as model of the eastern subunit was obtained by an intramolecular Ni0 mediated coupling reaction.