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2,6-Dichloro-7-methylpurine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2273-93-0 Structure
  • Basic information

    1. Product Name: 2,6-Dichloro-7-methylpurine
    2. Synonyms: 2,6-Dichloro-7-methyl-7h-purine ,98%;7H-Purine, 2,6-dichloro-7-methyl-;2,6-dichloro-7-methyl-purin;2,6-DICHLORO-7-METHYLPURINE;2,6-DICHLORO-7-METHYL-7H-PURINE;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
    3. CAS NO:2273-93-0
    4. Molecular Formula: C6H4Cl2N4
    5. Molecular Weight: 203.03
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2273-93-0.mol
  • Chemical Properties

    1. Melting Point: 195.5-196 °C
    2. Boiling Point: 307.247 °C at 760 mmHg
    3. Flash Point: 139.6 °C
    4. Appearance: Off-white crystalline powder
    5. Density: 1.76 g/cm3
    6. Vapor Pressure: 0.000733mmHg at 25°C
    7. Refractive Index: 1.76
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: -2.04±0.30(Predicted)
    11. CAS DataBase Reference: 2,6-Dichloro-7-methylpurine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2,6-Dichloro-7-methylpurine(2273-93-0)
    13. EPA Substance Registry System: 2,6-Dichloro-7-methylpurine(2273-93-0)
  • Safety Data

    1. Hazard Codes: Xi,Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2273-93-0(Hazardous Substances Data)

2273-93-0 Usage

Uses

2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.

Check Digit Verification of cas no

The CAS Registry Mumber 2273-93-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,7 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2273-93:
(6*2)+(5*2)+(4*7)+(3*3)+(2*9)+(1*3)=80
80 % 10 = 0
So 2273-93-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H4Cl2N4/c1-12-2-9-5-3(12)4(7)10-6(8)11-5/h2H,1H3

2273-93-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-dichloro-7-methylpurine

1.2 Other means of identification

Product number -
Other names 2,6-Dichloro-7-methyl-7H-purine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2273-93-0 SDS

2273-93-0Relevant articles and documents

Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ

Brik, Ashraf,Wu, Chung-Yi,Best, Michael D.,Wong, Chi-Huey

, p. 4622 - 4626 (2005)

Tremendous efforts have been invested in the synthesis of purine libraries due to their importance in targeting various enzymes involved in different diseases and cellular processes. The synthesis of N9-alkylated purine scaffolds relied mostly

Regioselective alkylation reaction of purines under microwave irradiation

Vinuesa, Arturo,Vi?as, Miquel,Jahani, Daniel,Ginard, Jaume,Mur, Nuria,Pujol, Maria Dolors

, p. 597 - 602 (2021/12/22)

The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide is complicated and in the best cases, mixtures of N-alkylated compounds are obtained. Purine derivatives can be acquired from alkylati

HYPOXANTHINE COMPOUND

-

Paragraph 0216, (2021/07/17)

PROBLEM TO BE SOLVED: To provide a novel compound having an inhibitory action of prolyl hydroxylase (PHDs) and useful as a therapeutic agent of an inflammatory bowel disease such as ulcerative colitis. SOLUTION: The present invention relates to a hypoxanthine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. The compound of the present invention or its pharmaceutically acceptable salt has an inhibitory effect of prolyl hydroxylase and is useful as a therapeutic agent for inflammatory bowel disease such as ulcerative colitis. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

SUBSTITUTED BICYCLIC PYRIMIDINE-BASED COMPOUNDS AND COMPOSITIONS AND USES THEREOF

-

Paragraph 00231; 00232, (2018/08/20)

Novel C-2-substituted bicyclic compounds of Formula I have been prepared and found to be useful as potent inhibitors of hGGPPS by inhibiting geranylgeranylation of proteins and inhibiting the biosynthesis of GGPP. The application is directed to these compounds, to compositions comprising these compounds, and to their use, in particular as medicaments for use in the treatment of cancer and other conditions which are treatable by inhibiting human geranylgeranylation pyrophosphate hGGPPS activity.

Direct, Regioselective N-Alkylation of 1,3-Azoles

Chen, Shuai,Graceffa, Russell F.,Boezio, Alessandro A.

supporting information, p. 16 - 19 (2016/01/15)

Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.

COMPOUNDS FOR IMPROVING MRNA SPLICING

-

Page/Page column 222; 223, (2016/08/10)

Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.

HETEROCYCLIC HYDROXAMIC ACIDS AS PROTEIN DEACETYLASE INHIBITORS AND DUAL PROTEIN DEACETYLASE-PROTEIN KINASE INHIBITORS AND METHODS OF USE THEREOF

-

Paragraph 00425; 00426, (2016/04/26)

The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mpsl kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mpsl k

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

Lee, Wendy,Ortwine, Daniel F.,Bergeron, Philippe,Lau, Kevin,Lin, Lichuan,Malek, Shiva,Nonomiya, Jim,Pei, Zhonghua,Robarge, Kirk D.,Schmidt, Stephen,Sideris, Steve,Lyssikatos, Joseph P.

, p. 5097 - 5104 (2013/09/12)

A series of N-7-methyl-imidazolopyrimidine inhibitors of the mTOR kinase have been designed and prepared, based on the hypothesis that the N-7-methyl substituent on imidazolopyrimidine would impart selectivity for mTOR over the related PI3Kα and δ kinases. The corresponding N-Me substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines also show potent mTOR inhibition with selectivity toward both PI3α and δ kinases. The most potent compound synthesized is pyrazolo[4,3-d]pyrimidine 21c. Compound 21c shows a Ki of 2 nM against mTOR inhibition, remarkable selectivity (>2900×) over PI3 kinases, and excellent potency in cell-based assays.

N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

-

Page/Page column 29, (2011/04/25)

The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4, Y1 and Y2 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.

N-9 SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

-

Page/Page column 25, (2011/04/25)

The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4 and D have the meaning described herein. The present invention also relates to pharmac

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