227609-85-0

Basic information

• Product Name: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)
• Synonyms: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI);2-Fluoro-5-(hydroxymethyl)benzonitrile
• CAS NO: 227609-85-0
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.1377432
• Product Categories: HALIDE
• Mol File: 227609-85-0.mol

Chemical Properties

• Boiling Point: 284.5 °C at 760 mmHg
• Flash Point: 125.8 °C
• Appearance: /
• Density: 1.27 g/cm³
• PKA: 13.93±0.10(Predicted)
• CAS DataBase Reference: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(227609-85-0)
• EPA Substance Registry System: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(227609-85-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 227609-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 2-fluoro-5-(hydroxymethyl)(9CI) is used as a key intermediate for the synthesis of anti-cancer agents, contributing to the development of pharmaceuticals that target and combat cancer cells. Its unique structure allows for the creation of drugs with potential therapeutic effects against various types of cancer.
Used in Agricultural Industry:
In the agricultural sector, Benzonitrile, 2-fluoro-5-(hydroxymethyl)(9CI) is utilized as a precursor in the production of pesticides, helping to develop compounds that protect crops from pests and diseases, thereby ensuring food security and crop yield.
Used in Organic Chemistry Research:
Benzonitrile, 2-fluoro-5-(hydroxymethyl)(9CI) is employed as a reagent in the development of new drug candidates, facilitating the exploration of novel chemical entities with potential medicinal properties. Its role in research is pivotal for advancing the frontiers of organic chemistry and discovering new applications in various fields.
Used in Synthesis of Other Organic Compounds:
As a starting material, Benzonitrile, 2-fluoro-5-(hydroxymethyl)(9CI) is instrumental in the preparation of a wide range of organic compounds, expanding the scope of chemical synthesis and enabling the creation of new molecules with diverse applications across different industries.

Upstream product

• 218301-22-5 2-fluoro-5-formylbenzonitrile 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 171050-06-9 3-cyano-4-fluorobenzoic acid 
• 557-21-1 zinc(II) cyanide 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 

Downstream Products

• 1423135-12-9 tert-butyl 4-{3-[(3R)-3-{[(1S)-1-{5-[(3-cyano-4-fluorobenzyl)oxy]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate 
• 1373152-21-6 C₁₄H₂₀FNOSi 
• 481075-38-1 2-fluoro-5-(hydroxymethyl)benzoic acid 
• 180302-35-6 5-bromomethyl-2-fluorobenzonitrile 

Relevant articles and documents

PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION

The compounds of Formula Ib, Formula Ia, and Formula I are described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The process of preparation of the compounds of Formula Ib, Formula Ia, and Formula I is also described. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are 2-(benzyloxy)pyrimidine derivatives that are inhibitors of PD-1/PD-L1 activation.

TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS

The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

GLUCOKINASE ACTIVATORS

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of wherein the variables are as defined herein.

PARP inhibitors

A compound of the formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R2, R3, R4 and R5 are independently selected from the group consisting of H, C1-7 /su

Potassium channel openers

Compounds having the formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Potassium channel openers

Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.