22841-92-5

Basic information

• Product Name: (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE;3-CHLORO-2-HYDRAZINOPYRIDINE;3-Chloro-2-hydrazinopyridine 98%;3-Chloro-2-hydrazinylpyridine;3-chloro-2-hydrazylpyridine;2-(3-chloropyridin-2-yl)hydrazine
• CAS NO: 22841-92-5
• Molecular Formula: C₅H₆ClN₃
• Molecular Weight: 143.57
• Product Categories: blocks;Pyridines;pharmacetical;Heterocycle-Pyridine series;amine|alkyl chloride
• Mol File: 22841-92-5.mol
• Article Data: 56

Chemical Properties

• Melting Point: 165-167°
• Boiling Point: 276.7 °C at 760 mmHg
• Flash Point: 121.1 °C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 0.00474mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.65±0.70(Predicted)
• CAS DataBase Reference: (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(22841-92-5)
• EPA Substance Registry System: (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(22841-92-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 22841-92-5(Hazardous Substances Data)

Usage

General Description

(3-Chloro-pyridin-2-yl)-hydrazine is a chemical compound with the molecular formula C5H5ClN4. It is a hydrazine derivative with a chloropyridine group attached to the hydrazine moiety. (3-CHLORO-PYRIDIN-2-YL)-HYDRAZINE has potential applications in the field of medicinal chemistry and pharmaceuticals due to its ability to interact with biological targets and exhibit biological activity. Its unique structure and properties make it a valuable building block for the synthesis of various organic compounds and pharmaceuticals. Studies have shown that (3-Chloro-pyridin-2-yl)-hydrazine has potential as an anti-tuberculosis agent, making it a promising candidate for the development of new drugs to combat tuberculosis. Additionally, it may also have potential applications in the development of agricultural and crop protection products.

InChI:InChI=1/C5H6ClN3/c6-4-2-1-3-8-5(4)9-7/h1-3H,7H2,(H,8,9)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 6515-09-9 2,3,6-trichloropyridine 
• 462-08-8 pyridin-3-ylamine 
• 79785-97-0 hydrazine hydrate 
• 54231-32-2 3-chloro-2-nitropyridine 

Downstream Products

• 500011-88-1 2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester 
• 1410073-12-9 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide 
• 1262305-51-0 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-ethoxyphenyl)-1H-pyrazole-5-carboxamide 
• 1410073-16-3 3-bromo-N-(3-chloro-4-fluorophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-18-5 3-bromo-1-(3-chloropyridin-2-yl)-N-(2,4-dimethylphenyl)-1H-pyrazole-5-carboxamide 
• 1217093-52-1 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-methyl-4-nitrophenyl)-1H-pyrazole-5-carboxamide 
• 1410073-23-2 3-bromo-1-(3-chloropyridin-2-yl)-N-(2,6-dimethylphenyl)-1H-pyrazole-5-carboxamide 
• 1373214-57-3 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-methyl-6-nitrophenyl)-1H-pyrazole-5-carboxamide 
• 1410073-27-6 3-bromo-N-(2-chloro-4-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-30-1 3-bromo-N-(2-bromo-4-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-32-3 3-bromo-N-(2-nitro-4-chlorophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-34-5 3-bromo-1-(3-chloropyridin-2-yl)-N-(2,5-dichlorophenyl)-1H-pyrazole-5-carboxamide 
• 1410073-35-6 3-bromo-N-(4-chloro-2,6-dimethylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-38-9 3-bromo-N-(4-bromo-2,6-dimethylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Synthesis, antifungal and insecticidal activity of novel [1,2,4]triazolo[4,3-a]pyridine derivatives containing a sulfide substructure

A series of [1,2,4]triazolo[4,3-a]pyridine derivatives bearing a sulfide substructure was designed, synthesized and characterized via 1H·NMR, 13C·NMR, IR and elemental analyses. Bioassay Results indicated some of the derivatives displayed good fungicidal activity on Rhizoctonia cerealis, moderated insecticidal activity against Plutella xylostella and good insecticidal activity on Helicoverpa armigera. The inhibitory effects of compounds 4g and 4u against Rhizotonia cerealis were 70.9% at 50 μg mL-1; the IC50 values of compounds 4d and 4s against Plutella xylostella were 43.87 and 50.75 μg mL-1, respectively. And the IC50 values of compounds 4d, 4q, and 4s on Helicoverpa armigera were 58.3, 77.14 and 65.31 μg mL-1, respectively, which were better than that of commercial chlorpyrifos (103.77 μg mL-1).

Synthesis and insecticidal activity of anthranilic diamides with hydrazone substructure

A series of anthranilic diamides with a hydrazone substructure was synthesised and characterised using 1H NMR, 13C NMR, IR and elemental analyses. The in vitro insecticidal activity of all the compounds was tested against Plutella xylostella. The results showed the synthesised compounds to possess good insecticidal activity. The LC50 values of compounds VIIg, VIIl, VIIm, VIIn exhibited excellent insecticidal activities, with the LC50 affording 7.92 mg L-1, 12.01 mg L-1, 0.62 mg L-1 and 10.71 mg L-1, respectively. These may prove to be useful as potential insecticidal agents.

Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-a]pyridine derivatives

A series of novel 1,2,4-triazolo[4,3- a]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by 1H

Synthesis and biological activity of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety

A series of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety was synthesized and characterized via 1H NMR, 13C NMR, IR, and elemental analyses. Bioassay results indicated some of the derivatives displayed good antifungal activities and insecticidal activity. The inhibition rates of 8-chloro-3-((2,6-difluorobenzyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine against Rhizotonia erealis and Helminthosporium maydis were 78.6% and 76.4% activities at 50?μg mL?1, respectively. And compound 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine showed >95% mortality at 500?μg mL?1 and >65% mortality at 200?μg mL?1 against Plutella xylostella, respectively. As well as 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine displayed >90% mortality at 500?μg mL?1 against Helicoverpa armigera. A preliminary structure activity relationship (SAR) is discussed.

Synthesis method of 3-chloro-2-hydrazinopyridine

The invention relates to a synthesis method of 3-chloro-2-hydrazinopyridine. The method comprises the following steps: carrying out sulfonation reaction on 3-chloropyridine serving as a raw material, and reacting the obtained intermediate with hydrazine hydrate to obtain the 3-chloro-2-hydrazinopyridine. The route is simple, the average yield of the product is not lower than 80%, and the purity of the product is 99.50% or above; reaction conditions are mild, operation is safe and simple, equipment requirements are not high, and the method is suitable for industrial production; and raw materials and auxiliary materials are conventional compounds, used solvents can be recycled, the catalyst is single, industrial three wastes are few, and the method is environment-friendly.

2-hydrazino-3-chloropyridine improvement process

The invention relates to the technical field of insecticides, and discloses a 2-hydrazino-3-chloropyridine improvement process which is characterized by comprising the steps of (1) adding alcohol amine, hydrazine hydrate and 2,3-dicyanopyridine into a pressure kettle, closing the reaction kettle, introducing nitrogen to keep a certain pressure, heating, and keeping the temperature to react for 6-12 hours until the content of the 2,3-dicyanopyridine is detected to be less than 0.5%; and (2) after the reaction is finished, relieving the pressure to normal pressure. According to the scheme, alcohol amine is used for absorbing hydrogen chloride generated in the synthesis reaction under the pressurization condition, after synthesis is finished, most of hydrogen chloride is desorbed and released through pressure reduction and temperature rise, and meanwhile, moisture in hydrazine hydrate serving as a raw material is removed. Nitrogen is used for further air stripping, so that residual free acid is reduced after the filter cake is separated, and the filter cake is washed more easily to be qualified; and by using the scheme, excessive hydrazine hydrate is reduced, and waste water and safety risks caused by hydrazine hydrate recovery due to salification of hydrazine hydrate and hydrogen chloride are avoided.