500011-88-1Relevant articles and documents
Preparation method of pyridyl pyrazolidinone carboxylic acid compound
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Paragraph 0031-0038; 0043-0046; 0052-0054, (2022/03/17)
The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of a pyridyl pyrazolidinone carboxylic ester compound. The reaction formula is shown in the specification, each group in the formula being defined in the specification. The invention provides a method for preparing a key intermediate pyridyl pyrazolidinone carboxylic ester compound of benzamide insecticides, and by adopting the method provided by the invention, the yield of a product is improved, the energy consumption is reduced, and industrial production is facilitated.
Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities
Chen, Rui-Jia,Cheng, Jia-Gao,Dong, Le-Feng,Feng, Ting-Ting,Gu, Yu-Cheng,Li, Zhong,Shao, Xu-Sheng,Wang, Gang-Ao,Wang, Jun-Jie,Xu, Xiao-Yong,Xu, Zhi-Ping,Zhou, Cong
, (2022/02/03)
Diamide insecticides, represented by chlorantraniliprole (CHL), were widely applied in the control of lepidopteran insects. In efforts to develop bioactive diamides with novel scaffolds, we design and synthesized a series of diamides containing central amino acids to conformationally simulate CHL. Bioassay results indicated that most compounds containing 1-aminocyclopropane-1-carboxylic acid exhibited excellent larvacidal potency against Mythimna separate and Plutella xylostella. After a systematic structure–activity relationship study, 1–23 was identified as a potential insecticidal candidate with LC50 values of 34.920 mg·L?1 against M. separate and 61.992 mg·L?1 on P. xylostella. Finally, molecular docking revealed the possible binding mode of 1–23 with the target protein, ryanodine receptors.
N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF
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, (2021/01/25)
The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R1 is selected from halo or C1-C3 alkyl; R2