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1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene is a complex organic sulfone derivative characterized by a molecular formula of C18H20O6S2. It features a benzene ring with multiple substituents, including two sulfonyl groups, which may contribute to its potential reactivity and applications in various fields such as pharmaceuticals or industry.

24124-59-2

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24124-59-2 Usage

Uses

Given the provided materials, there are no specific applications listed for 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene. However, based on its chemical structure and the nature of similar compounds, potential uses could be hypothesized in the following industries:
Used in Pharmaceutical Industry:
1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene could be used as a pharmaceutical intermediate for the synthesis of drugs with specific therapeutic effects. Its complex structure and sulfonyl groups may allow it to interact with biological targets, potentially leading to the development of new medications.
Used in Chemical Industry:
In the chemical industry, 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene might serve as a reactant or catalyst in various chemical processes. Its reactivity and functional groups could be harnessed to facilitate specific chemical transformations or to improve the efficiency of industrial processes.

Check Digit Verification of cas no

The CAS Registry Mumber 24124-59-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,2 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 24124-59:
(7*2)+(6*4)+(5*1)+(4*2)+(3*4)+(2*5)+(1*9)=82
82 % 10 = 2
So 24124-59-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H16O6S2/c1-12-3-7-14(8-4-12)22(16,17)20-11-21-23(18,19)15-9-5-13(2)6-10-15/h3-10H,11H2,1-2H3

24124-59-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-methylphenyl)sulfonyloxymethyl 4-methylbenzenesulfonate

1.2 Other means of identification

Product number -
Other names Methanediol,di-p-toluenesulfonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24124-59-2 SDS

24124-59-2Relevant articles and documents

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

Delost, Michael D.,Njardarson, Jon T.

supporting information, p. 6121 - 6125 (2021/08/16)

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

HPLC-free: In situ 18F-fluoromethylation of bioactive molecules by azidation and MTBD scavenging

Lu, Yingqing,Choi, Ji Young,Kim, Sang Eun,Lee, Byung Chul

supporting information, p. 11798 - 11801 (2019/10/02)

Sequential usage of azide and MTBD, which generates pure [18F]fluoromethyl tosylate and scavenges unreacted desmethyl precursors, provided an efficient HPLC-free strategy for the radiosynthesis of 18F-fluoromethylated compounds with

A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol

Brocklesby, Kayleigh L.,Waby, Jennifer S.,Cawthorne, Christopher,Smith, Graham

supporting information, p. 1635 - 1637 (2018/04/02)

Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).

Synthesis and evaluation of [18F]-fluoromethyl triphenylphosphonium cation as a novel mitochondria-specific positron emission tomography tracer

Zeng, Huahui,Wu, Xiangxiang,Song, Fahuan,Xu, Caiyun,Liu, Hao,Liu, Wendi

, p. 90 - 97 (2016/05/10)

We developed a radiosynthesis of the voltage sensitive tracer [18F]-fluoromethyltriphenylphosphonium cation ([18F]-FTPMP), giving high yield (30-34%, decay-corrected), radiochemical purity (>99%) and specific activity (about 760 GBq/

11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography

Cantore, Mariangela,Benadiba, Marcel,Elsinga, Philip H.,Kwizera, Chantal,Dierckx, Rudi A. J. O.,Colabufo, Nicola Antonio,Luurtsema, Gert

, p. 108 - 118 (2016/01/15)

P-Glycoprotein (P-gp) is an efflux transporter widely expressed at the human blood-brain barrier. It is involved in xenobiotics efflux and in onset and progression of neurodegenerative disorders. For these reasons, there is great interest in the assessmen

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability

Zhang, Zhaoda,Kil, Kun-Eek,Poutiainen, Pekka,Choi, Ji-Kyung,Kang, Hye-Jin,Huang, Xi-Ping,Roth, Bryan L.,Brownell, Anna-Liisa

supporting information, p. 3956 - 3960 (2015/08/24)

Abstract In recent years, mGlu4 has received great attention and research effort because of the potential benefits of mGlu4 activation in treating numerous brain disorders, such as Parkinson's disease (PD). Many positive allosteric m

Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: Synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism

Schwan, Gregor,Barbar Asskar, Ghadir,Hoefgen, Norbert,Kubicova, Lenka,Funke, Uta,Egerland, Ute,Zahn, Michael,Nieber, Karen,Scheunemann, Matthias,Straeter, Norbert,Brust, Peter,Briel, Detlef

supporting information, p. 1476 - 1487 (2014/07/21)

Based on the potent phosphodiesterase 10 A (PDE10A) inhibitor PQ-10, we synthesized 32 derivatives to determine relationships between their molecular structure and binding properties. Their roles as potential positron emission tomography (PET) ligands were evaluated, as well as their inhibitory potency toward PDE10A and other PDEs, and their metabolic stability was determined in vitro. According to our findings, halo-alkyl substituents at position 2 of the quinazoline moiety and/or halo-alkyloxy substituents at positions 6 or 7 affect not only the compounds′ affinity, but also their selectivity toward PDE10A. As a result of substituting the methoxy group for a monofluoroethoxy or difluoroethoxy group at position 6 of the quinazoline ring, the selectivity for PDE10A over PDE3A increased. The same result was obtained by 6,7-difluoride substitution on the quinoxaline moiety. Finally, fluorinated compounds (R)-7-(fluoromethoxy)-6-methoxy-4-(3-(quinoxaline-2-yloxy)pyrrolidine-1-yl) quinazoline (16 a), 19 a-d, (R)-tert-butyl-3-(6-fluoroquinoxalin-2-yloxy) pyrrolidine-1-carboxylate (29), and 35 (IC50 PDE10A 11-65 nM) showed the highest inhibitory potential. Further, fluoroethoxy substitution at position 7 of the quinazoline ring improved metabolic stability over that of the lead structure PQ-10. Fluor your health: Phosphodiesterase 10 A (PDE10A) has emerged as an attractive target for the development of 18F-labelled brain imaging agents for positron emission tomography. A series of fluorinated dialkoxybiaryl compounds were synthesized and evaluated as PDE10A inhibitors, assisted by QSAR docking studies. The 7-fluoromethoxy derivative appears to be a promising candidate for further development.

2-PYRIDYLOXY-4-ETHER OREXIN RECEPTOR ANTAGONISTS

-

Page/Page column 62, (2014/09/29)

The present invention is directed to 2-pyridyloxy-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-4-ether compounds described herein in the potential treatment or prevention o

NOVEL PRECURSOR

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Page/Page column 40, (2012/04/10)

Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endomet

NOVEL RADIOTRACER

-

Page/Page column 39-40, (2012/04/10)

Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endomet

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