2524-49-4 Usage
Uses
Used in Organic Synthesis:
3-Buten-1-amine is used as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its reactivity allows it to participate in a wide range of reactions, such as nucleophilic addition, reductive amination, and Michael addition, making it a valuable component in the development of new molecules and materials.
Used in Proteomics Research:
In the field of proteomics, 3-buten-1-amine plays a crucial role in the study of proteins and their interactions. It is used to modify proteins and peptides, enabling researchers to investigate their structure, function, and dynamics. This modification can also improve the solubility and stability of proteins, facilitating their analysis and manipulation.
Used in Neurodegenerative Disease Detection:
3-Buten-1-amine's hydrochloride salt is utilized in the detection of neurodegenerative diseases, such as Alzheimer's, through enzyme-linked immunosorbent assay (ELISA) titrations. It helps to enhance the specificity of the assay by reducing the background signal caused by non-specific associations of molecules and proteins. This improvement in detection sensitivity and specificity is vital for the accurate diagnosis and monitoring of Alzheimer's disease and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2524-49-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,2 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2524-49:
(6*2)+(5*5)+(4*2)+(3*4)+(2*4)+(1*9)=74
74 % 10 = 4
So 2524-49-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H9N/c1-2-3-4-5/h2H,1,3-5H2
2524-49-4Relevant articles and documents
A Peptide Backbone Stapling Strategy Enabled by the Multicomponent Incorporation of Amide N-Substituents
Ricardo, Manuel G.,Marrrero, Javiel F.,Valdés, Oscar,Rivera, Daniel G.,Wessjohann, Ludger A.
supporting information, p. 769 - 774 (2019/01/04)
The multicomponent backbone N-modification of peptides on solid-phase is presented as a powerful and general method to enable peptide stapling at the backbone instead of the side chains. This work shows that a variety of functionalized N-substituents suitable for backbone stapling can be readily introduced by means of on-resin Ugi multicomponent reactions conducted during solid-phase peptide synthesis. Diverse macrocyclization chemistries were implemented with such backbone N-substituents, including the ring-closing metathesis, lactamization, and thiol alkylation. The backbone N-modification method was also applied to the synthesis of α-helical peptides by linking N-substituents to the peptide N-terminus, thus featuring hydrogen-bond surrogate structures. Overall, the strategy proves useful for peptide backbone macrocyclization approaches that show promise in peptide drug discovery.
