25529-00-4Relevant articles and documents
β-Lactoglobulin Directed Photoisomerization of Retinal and Related Compounds
Li, Xiao-yuan,Asato, Alfred E.,Liu, R. S. H.
, p. 4841 - 4844 (1990)
The 11-cis enriched photostationary state mixture of retinal trapped in BLG, a water soluble protein, is similar to that of retinal in heptanol.The results, along with those of the lower homologs, are consistend with a model involving specific protein interaction with the cyclohexenyl portion of the substrate and remote protonation of the aldehyde carbonyl group.
A synthesis method of 9-cis Beta-carotene
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, (2021/05/18)
The present invention relates to a method for synthesizing 9 - cis Beta-carotene (9 - cis beta-carotene) compounds having high purity and easy mass production through a chemical reaction, and a reaction for substituting 9 - cis Retinol groups of Alcohol with 9 - cis Phosphonium salt. The reaction of β - (3 - Methyl-2-butenal to Knoevenagel condensation) to synthesize All-trans Aldehyde. In step 9 - cis Retinoic Phosphonium salt) and in step), the completed All-trans Aldehyde is subjected to Wittig Olefination reaction with carbon double bonds, and 9. cis Beta-carotene obtained by the reaction of carbon double bonds.
Efficient generation of a trisporoid library by combination of synthesis and biotransformation
Schachtschabel, Doreen,Boland, Wilhelm
, p. 1366 - 1372 (2007/10/03)
(Chemical Equation Presented) Trisporic acids and their biosynthetic precursors represent a family of powerful fungal pheromones and morphogenetic factors. A highly flexible synthetic protocol is described that (i) provides rapid access to nonfunctionaliz
Syntheses of new 9- and 13-methylene isomers of retinal
Laurent,Prat,Valla,Andriamialisoa,Giraud,Labia,Potier
, p. 7221 - 7224 (2007/10/03)
Syntheses of new 9- and 13-methylene isomers of retinal via the '9-methylene-C-18 ketone' 1 or 'C-18 ketone' 2 are reported. (C) 2000 Published by Elsevier Science Ltd.
Synthesis of 9-cis-retinoic acid and C-20-[3H3C]-9-cis-retinoic acid with high specific activity
Tadikonda, Praveen K.,Lacy, James M.,Rigdon, Michael G.,Deluca, Hector F.
, p. 1 - 10 (2007/10/03)
The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcyclohexanone is described. The same methodology was extended for the synthesis of deuterium and tritium labeled 9-cis-retinoic acid with high specific activity (73 Ci/mmol). In this methodology, a Grignard reaction was utilized for introducing three tritium atoms simultaneously in the final synthetic steps.
Polyvinylogation Reagents: 1-Lithio-4-trimethylsiloxy-penta-1,3-diene and 1-Lithio-4-ethoxy-2-methyl-buta-1,3-diene
Duhamel, Lucette,Ancel, Jean-Erick
, p. 9237 - 9250 (2007/10/02)
Title products, lithiodienol ethers 6a and 7a, synthetic equivalents of 4-lithio pent-3-ene-2-one and 4-lithio-senecialdehyde were obtained by bromine-lithium exchange.They are choice reagents for the transformations 1 -> 2 and 1 -> 3, respectively.
Synthesis of 8-, 9-, 12-, and 13-mono-13C-retinal
Pardoen, J. A.,Mulder, P. P. J.,Berg, E. M. M. van den,Lugtenburg, J.
, p. 1431 - 1435 (2007/10/02)
The 8-, 9-, 12-, and 13-mono-13C-retinals were synthesized with >98percent chemical purity and 93percent 13C incorporation from 13C-labelled acetonitrile.Their 13C-13C and 13C-1H nmr coupling constants were determined.
A CONVENIENT ROUTE TO α,β-UNSATURATED METHYL KETONES APPLICATION TO RETINAL ANALOGUE SYNTHESIS
Croteau, Allan A.,Termini, John
, p. 2481 - 2484 (2007/10/02)
Deprotonated ketimines 1a,b add to aldehydes and ketones to provide tri- and tetra-substituted α,β-unsaturated methyl ketones 2a,b with substantial percentage of Z-geometry which are not readily accessible by other methods.
PHOTOISOMERIZATION OF THE C18 KETONE IN THE VITAMIN A SERIES. SOLVENT EFFECT ON PHOTOISOMERIZATION OF COMPOUNDS RELATED TO RETINAL
Ramamurthy, V.,Denny, M.,Liu, R. S. H.
, p. 2463 - 2466 (2007/10/02)
The directions of photoisomerization of polyenals and polyenones are believed to be controlled by the relative ordering of n,?* and ?,?* states.
4-ω-BROMOALKAPOLYENYLMETHYL KETONES-II; USE OF 5-BROMO-3-PENTEN-2-ONE ETHYLENE KETAL AS A C5-SYNTHON
Camps, J.,Font, J.,March, P. De
, p. 2493 - 2500 (2007/10/02)
The preparation of the phosphonium salt and the dimethyl-phosphonate of (E)-5-bromo-3-penten-2-one ethylene ketal, 6 and 7, is described.These C5-isoprenoid synthons were condensed with several aldehydes and ketones giving mixtures of the corresponding E
