25563-14-8

Basic information

• Product Name: 4-chloro-N-methoxybenzamide
• Synonyms: 4-chloro-N-methoxybenzamide
• CAS NO: 25563-14-8
• Molecular Weight: 185.61
• Mol File: 25563-14-8.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-methoxybenzamide(25563-14-8)
• EPA Substance Registry System: 4-chloro-N-methoxybenzamide(25563-14-8)

Safety Data

• Hazardous Substances Data: 25563-14-8(Hazardous Substances Data)

Upstream product

• 57139-20-5 potassium p-chlorobenzohydroxyamate 
• 74-88-4 methyl iodide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 593-56-6 N-methoxylamine hydrochloride 
• 74-11-3 para-chlorobenzoic acid 
• 67-62-9 O-Methylhydroxylamin 
• 122-01-0 4-chloro-benzoyl chloride 
• 57139-34-1 (Z)-O-methyl-p-chlorobenzohydroximoyl chloride 

Downstream Products

• 186768-19-4 N-methoxy-N-propargyl-p-chlorobenzamide 
• 1202932-79-3 4-chloro-N,2-dimethoxybenzamide 
• 1202932-89-5 4-chloro-2-ethoxy-N-methoxybenzamide 
• 155694-56-7 (E)-4-chloro-2-styrylbenzamide 
• 162192-37-2 N-(3,5-dimethylbenzyl)-N-methoxy-4-chlorobenzamide 
• 1141-35-1 2-(4-chlorophenyl)benzoxazole 
• 1456693-86-9 5-chloro-3-hydroxy-2-methoxy-3-phenylisoindolin-1-one 
• 1346684-68-1 6-chloro-2,3-diphenylisoquinolin-1-(2H)-one 
• 33184-56-4 2-benzoyl-4-chlorobenzoic acid 
• 1364511-70-5 6-chloro-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 253663-25-1 (Z)-4-chloro-N-methoxybenzenecarboximidoyl fluoride 
• 253663-30-8 (E)-4-chloro-N-methoxybenzenecarboximidoyl fluoride 
• 1581719-96-1 4-chloro-N-methoxy-2-((triisopropylsilyl)ethynyl)benzamide 
• 1609939-43-6 6-chloro-2-methoxy-3-phenylisoquinolin-1(2H)-one 

Relevant articles and documents

Harnessing hypervalent iodonium ylides as carbene precursors: C-H activation of: N -methoxybenzamides with a Rh(iii)-catalyst

Hypervalent iodonium ylides expeditiously generate carbenes which undergo domino intermolecular C-H activation followed by intramolecular condensation in the presence of N-methoxybenzamide as a starting material and a Rh(iii)-catalyst to afford dihydrophenanthridines. KIE studies and DFT calculations were performed to substantiate the mechanistic pathway. To extend the synthetic utilisation, fluorescent pyranoisocoumarins were achieved by using Rh(iii)-catalyzed peri-C-H/O-H activation/annulation reactions.

Palladium-Catalyzed Inert C?H Bond Activation and Cyclocarbonylation of Isoquinolones with Carbon Dioxide Leading to Isoindolo[2,1-b]isoquinoline-5,7-Diones

A palladium-catalyzed inert C?H bond activation and cyclocarbonylation of isoquinolones leading to isoindolo[2,1-b]isoquinoline-5,7-diones under 1 atm of carbon dioxide has been developed. This transformation features high regio- and chemo-selectivity, step-economy, and good functional group tolerance. Most of the corresponding products were obtained in moderate to good yields. It offers an alternative approach for the synthesis of useful diverse isoindolo[2,1-b]isoquinoline-5,7-dione derivatives. (Figure presented.).

Rhodium(III)-catalyzed chemodivergent annulations between: N-methoxybenzamides and sulfoxonium ylides via C-H activation

Chemodivergent and redox-neutral annulations between N-methoxybenzamides and sulfoxonium ylides have been realized via Rh(iii)-catalyzed C-H activation. The sulfoxonium ylide acts as a carbene precursor, and coupling occurs under acid-controlled condition