262849-34-3

Basic information

• Product Name: (S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran
• Synonyms: (S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran
• CAS NO: 262849-34-3
• Molecular Weight: 368.473
• Mol File: 262849-34-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran(262849-34-3)
• EPA Substance Registry System: (S)-(+)-2-acetoxymethyl-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran(262849-34-3)

Safety Data

• Hazardous Substances Data: 262849-34-3(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 171270-07-8 (6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methanol 
• 100-44-7 benzyl chloride 
• 56305-04-5 trolox 
• 53713-36-3 rac-2-methoxy-3,4-dihydro-2,5,7,8-tetramethyl-6-(phenylmethoxy)-2H-1-benzopyran 
• 100-39-0 benzyl bromide 
• 53209-24-8 2,5,7,8-tetramethyl-2-methoxy-6-hydroxychroman 
• 700-13-0 Trimethylhydroquinone 
• 3396-11-0 cesium acetate 
• 865444-18-4 4-(benzyloxy)-2,3,5-trimethyl-6-(3-methylbut-3-en-1-yl)phenol 
• 210174-90-6 methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate 
• 86646-83-5 methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate 
• 163037-44-3 Acetic acid (S)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethyl ester 

Downstream Products

• 1263473-57-9 (S)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethyl (R)-α-methoxy-α-phenyl-α-trifluoromethylacetate 
• 906079-28-5 (S)-[3,4-dihydro-6-benzyloxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl]methyl trifluoromethane-sulfonate 
• 69400-39-1 (+) (S)-6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-carbaldhyde 
• 69371-87-5 (S)-(-)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol 

Relevant articles and documents

Enantioselective Halo-oxy- and Halo-azacyclizations Induced by Chiral Amidophosphate Catalysts and Halo-Lewis Acids

Catalytic enantioselective halocyclization of 2-alkenylphenols and enamides have been achieved through the use of chiral amidophosphate catalysts and halo-Lewis acids. Density functional theory calculations suggested that the Lewis basicity of the catalyst played an important role in the reactivity and enantioselectivity. The resulting chiral halogenated chromans can be transformed to α-Tocopherol, α-Tocotrienol, Daedalin A and Englitazone in short steps. Furthermore, a halogenated product with an unsaturated side chain may provide polycyclic adducts under radical cyclization conditions.

Enantioselective transesterification of (±)-6-benzyloxy-2,5,7,8- tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol catalyzed by the Amano PS lipase in the ionic liquid [bmim]PF6

(S)-(-)-6-Benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2- ylmethanol, a synthon for the design of natural α-tocopherol, was obtained by kinetically selective acetylation of the corresponding racemic alcohol in the presence of the Amano PS lipase from Burkholderia cepacia in the ionic liquid 1-butyl-3-methylimidazolinium hexafluorophosphate ([bmim]PF6).