26387-53-1

Basic information

• Product Name: TRIETHYL ORTHOFORMATE-D1
• Synonyms: TRIETHYL ORTHOFORMATE-D1
• CAS NO: 26387-53-1
• Molecular Formula: C₇H₁₆O₃
• Molecular Weight: 149.206301778
• Mol File: 26387-53-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TRIETHYL ORTHOFORMATE-D1(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYL ORTHOFORMATE-D1(26387-53-1)
• EPA Substance Registry System: TRIETHYL ORTHOFORMATE-D1(26387-53-1)

Safety Data

• Hazardous Substances Data: 26387-53-1(Hazardous Substances Data)

Usage

General Description

Triethyl Orthoformate-d1 is a deuterated form of the chemical triethyl orthoformate, which is commonly used as a reagent in organic synthesis reactions. It contains deuterium, a stable isotope of hydrogen, at the ortho position of the orthoformate group. This deuteration can be advantageous in certain experiments due to its effects on chemical reactivity and stability. Triethyl Orthoformate-d1 is often employed in the preparation of deuterated compounds for nuclear magnetic resonance (NMR) spectroscopy studies, where the deuterium atoms can provide valuable information about molecular structures and dynamics. Additionally, it can serve as a solvent in various chemical reactions, offering improved resolution and sensitivity in NMR experiments compared to non-deuterated solvents.

Upstream product

• 865-49-6 chloroform-d1 
• 925-93-9 ethyl [2]alcohol 

Downstream Products

• 1245720-34-6 (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-5-deutero-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide 
• 183435-32-7 3-deuterio-3,3-diethoxy-1-(phenylseleno)-1-propyne 
• 35976-76-2 ethyl deuterioformate 
• 75-65-0 tert-butyl alcohol 
• 105-58-8 Diethyl carbonate 

Relevant articles and documents

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs) from five key core intermediates A-E is described. These core compounds were obtained from myo-inositol orthoformate 1 via regioselective DIBAL-H and trimethylaluminium-mediated cleavages and a resolution-protection process using camphor acetals 10. Coupling of cores A-E with phosphoramidites 34 and 38, derived from the requisite protected lipid side chains, afforded the fully-protected PIPs. Removal of the remaining protecting groups was achieved via hydrogenolysis using palladium black or palladium hydroxide on carbon in the presence of sodium bicarbonate to afford the complete family of dipalmitoyl- and amino-PIP analogues 42, 45, 50, 51, 58, 59, 67, 68, 76, 77, 82, 83, 92, 93, 99 and 100. Investigations using affinity probes incorporating these compounds have identified novel proteins involved in the PI3K intracellular signalling network and have allowed a comprehensive proteomic analysis of phosphoinositide interacting proteins. The Royal Society of Chemistry 2010.