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  • 2650-67-1 Structure
  • Basic information

    1. Product Name: Z-GLN-OME
    2. Synonyms: N-ALPHA-CARBOBENZOXY-L-GLUTAMINE ALPHA-METHYL ESTER;Z-GLUTAMINE-OME;Z-GLN-OME;Z-L-GLUTAMINE METHYL ESTER;N2-[(Phenylmethoxy)Carbonyl]-L-Glutamine Methyl Ester;Z-L-Gln-OMe;Z-L-glutamine methyl ester≥ 98% (HPLC)
    3. CAS NO:2650-67-1
    4. Molecular Formula: C14H18N2O5
    5. Molecular Weight: 294.3
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2650-67-1.mol
  • Chemical Properties

    1. Melting Point: 138-139 °C
    2. Boiling Point: 542.1±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.235±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: -15°C
    8. Solubility: N/A
    9. PKA: 10.83±0.46(Predicted)
    10. CAS DataBase Reference: Z-GLN-OME(CAS DataBase Reference)
    11. NIST Chemistry Reference: Z-GLN-OME(2650-67-1)
    12. EPA Substance Registry System: Z-GLN-OME(2650-67-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2650-67-1(Hazardous Substances Data)

2650-67-1 Usage

Chemical Properties

White solid

Check Digit Verification of cas no

The CAS Registry Mumber 2650-67-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,5 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2650-67:
(6*2)+(5*6)+(4*5)+(3*0)+(2*6)+(1*7)=81
81 % 10 = 1
So 2650-67-1 is a valid CAS Registry Number.

2650-67-1Relevant articles and documents

A Novel compound

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Paragraph 0072-0073; 0087-0088; 0106-0108; 0146-0148, (2021/06/15)

The present invention relates to a novel compound and uses thereof. The novel compound according to the present invention, by inducing the activation of an MKP-1 protein, has an effect of inhibiting inflammatory responses very effectively that occur in respiratory diseases by blocking cell signaling in the order of p38/CK2alpha/NF-kappaB. Accordingly, it is possible to prevent, alleviate or treat the respiratory diseases by oral administration of the novel compound of the present invention.

GLUTAMINASE INHIBITORS

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Paragraph 0105, (2019/10/20)

Disclosed are newly identified chemotherapeutic agents. These inhibitors are particularly useful in the treatment of cancers such as leukemic cells and pancreatic cancers.

Substituted 2-(2, 6-Dioxopiperidin-3-yl)-1-method of preparing oxoisoindolines

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Paragraph 0080, (2018/11/22)

The present invention concerns new processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines which are useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF±. The i

An access to aza-Freidinger lactams and E-locked analogs

Ottersbach, Philipp A.,Schmitz, Janina,Schnakenburg, Gregor,Gütschow, Michael

supporting information, p. 448 - 451 (2013/04/11)

Freidinger lactams, possessing a peptide bond configuration locked to Z, are important key elements of conformationally restricted peptidomimetics. In the present work, the CαHi+1 unit has been replaced by N, leading to novel aza-Fre

Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles

Woodard, Scott S.,Jerome, Kevin D.

experimental part, p. 132 - 137 (2012/04/18)

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.

Synthesis of imidazolidin-2-one-4-carboxylate and of (tetrahydro)pyrimidin- 2-one-5-carboxylate via an efficient modification of the Hofmann rearrangement

Angelici, Gaetano,Contaldi, Simone,Lynn Green, Sarah,Tomasini, Claudia

experimental part, p. 1849 - 1852 (2008/10/09)

A mild and efficient methodology for the rearrangement of protected asparagine and protected glutamine is reported; good results are obtained with a wide selection of protecting groups. The Royal Society of Chemistry.

Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors

Abe, Masatoshi,Akiyama, Tetsuo,Umezawa, Yoji,Yamamoto, Keiichiro,Nagai, Masashi,Yamazaki, Hiroko,Ichikawa, Yuh-Ichiro,Muraoka, Yasuhiko

, p. 785 - 797 (2007/10/03)

The structure of sulphostin (1), a novel dipeptidyl peptidase IV (DPP-IV) inhibitor, is consisted of three key functional groups, including a characteristic amino(sulfoamino)phosphinyl group, on a piperidine ring. To examine the relationship between its s

Utility of tetrathiomolybdate and tetraselenotungstate: Efficient synthesis of cystine, selenocystine, and their higher homologues

Bhat, Ramakrishna G.,Porhiel, Emmanuel,Saravanan, Vadivelu,Chandrasekaran, Srinivasan

, p. 5251 - 5253 (2007/10/03)

Efficient synthesis of cystine, selenocystine, and their higher homologues like homo and bishomo amino acid derivatives from natural amino acid derivatives using tetrathiomolybdate and tetraselenotungstate reagents under mild and neutral conditions is reported. The generality of the reaction has been studied by capping various groups to amino and carboxyl components of canonical amino acids.

A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

Reddy, Dandu R,Iqbal, Mohamed A,Hudkins, Robert L,Messina-McLaughlin, Patricia A,Mallamo, John P

, p. 8063 - 8066 (2007/10/03)

A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.

New reaction conditions using trifluoroethanol for the E-I Hofmann rearrangement

Matsumura, Yoshihiro,Yuki Satoh, Kimihiro Shirai,Onomura, Osamu,Toshihide, Maki

, p. 2057 - 2060 (2007/10/03)

The Hofmann rearrangement of -protected glutamine esters to N2-protected (2S)-4-[(2,2,2-trifluoroethoxy)carbonyIamino]-2-aminobutyric acid esters was successfully achieved by an electrochemical method using a trifluoroethanol (TFE)-MeCN solvent system where the TFE may play an important role in controlling the basicity caused by electrochemically generated bases.

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