26862-71-5

Basic information

• Product Name: ethyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2-carboxylate
• CAS NO: 26862-71-5
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.2732
• Mol File: 26862-71-5.mol

Chemical Properties

• Boiling Point: 408.2°C at 760 mmHg
• Flash Point: 200.7°C
• Density: 1.268g/cm³
• Vapor Pressure: 7.13E-07mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: ethyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2-carboxylate(26862-71-5)
• EPA Substance Registry System: ethyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2-carboxylate(26862-71-5)

Safety Data

• Hazardous Substances Data: 26862-71-5(Hazardous Substances Data)

Upstream product

• 14891-10-2 ethyl-3-oxo-1-pyrrolidinecarboxylate 
• 529-23-7 o-aminobenzaldehyde 
• 541-41-3 chloroformic acid ethyl ester 
• 30125-83-8 2-benzyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline 
• 10222-53-4 quinoline-2,3-dicarbaldehyde 
• 3751-82-4 ethyl 1-ethoxycarbonyl-4-oxopyrrolidine-3-carboxylate 
• 111877-76-0 3-[1,3]dioxalalan-2-yl-2iodo-quinoline 
• 778593-72-9 3-(1,3-dioxolan-2-yl)-quinoline-2-carbaldehyde 
• 80231-40-9 2-iodo-3-quinolinecarboxaldehyde 

Downstream Products

• 55854-89-2 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one 
• 229176-20-9 3-methyl-4-oxo-2-(1-phenylcarbonyloxypropyl)-4,6-dihydroindolizino[1,2-b]quinoline 
• 229176-19-6 3-chloromethyl-4-oxo-2-(1-phenylcarbonyloxypropyl)-4,6-dihydroindolizino[1,2-b]quinoline 

Relevant articles and documents

Facile syntheses of ABC ring skeleton of camptothecin and related alkaloids

Facile synthetic approaches toward the preparation of ABC ring of camptothecin and related alkaloids starting from cheaper and readily available chemical reagents.

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Several pyrrolo-quinoline γ-lactones were found as novel inhibitors for two members of the PI3-kinase related kinase (PIKK) family. Ataxia-Telangiectasia-mutated (ATM) protein and the mammalian Target of Rapamycin (mTOR). Preliminary structure-activity relationship studies indicated that an electrophilic exocyclic double bond conjugated to the carbonyl group of the γ-lactone ring was crucial for the PIKK inhibitory potency. One of the best ATM inhibitors in this series, DK8G557, showed IC50 values of 0.6 and 7.0 μM for ATM and mTOR, respectively. This compound exhibited potent and selective growth inhibition activities in the NCI 60 human tumor cell line screen with a GI50 MG-MID value of 2.69 μM. The best mTOR inhibitor in this series, HP9912, exhibited IC50 values of 0.5 and 6.5 μM for mTOR and ATM, respectively. These compounds suggest novel leads for the discovery of potent small molecule inibitors of PIKKs as potential anticancer drugs, with therapeutic activities as either single, or as sensitizing agents to conventional radio-, or chemo-therapeutic strategies. Copyright

A convergent total synthesis of mappicine ketone: A leading antiviral compound

An efficient total synthesis of the naturally occuring mappicine ketone 1 and mappicine 2 are described. The approach is based on the assembly of tricyclic amine 5 with pseudo acid chloride 20. A Friedlander condensation is utilized for the construction o

Microwave assisted friedlander condensation catalyzed by clay

Clay catalyzed Friedlander condensation of 2-amino arylaldehyde or ketone with carbonyl compounds containing α-methylene group has been achieved in solvent free condition under microwave irradiation to give polycyclic quinoline derivatives.