3751-82-4

Basic information

• Product Name: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER;4-ketopyrrolidine-1,3-dicarboxylic acid diethyl ester;diethyl 4-oxopyrrolidine-1,3-dicarboxylate;4-Oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-eth
• CAS NO: 3751-82-4
• Molecular Formula: C₁₀H₁₅NO₅
• Molecular Weight: 229.2298
• Mol File: 3751-82-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 59-62 °C
• Boiling Point: 333°Cat760mmHg
• Flash Point: 155.2°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.489
• PKA: 11.19±0.20(Predicted)
• CAS DataBase Reference: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(3751-82-4)
• EPA Substance Registry System: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(3751-82-4)

Safety Data

• Hazardous Substances Data: 3751-82-4(Hazardous Substances Data)

Usage

General Description

4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER is a chemical compound that is commonly used in the pharmaceutical and research industries. It is a diethyl ester derivative of pyrrolidinedione, and has been studied for its potential as a precursor in the synthesis of various organic compounds. 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER has a wide range of potential applications, including use as a building block in the production of drugs, agrochemicals, and other fine chemicals. It is also used as a reagent in organic synthesis and as a catalyst in various chemical reactions. The compound's properties and potential uses make it an important and versatile chemical in the field of organic chemistry.

InChI:InChI=1/C10H15NO5/c1-3-15-9(13)7-5-11(6-8(7)12)10(14)16-4-2/h7H,3-6H2,1-2H3

Upstream product

• 999-30-4 ethyl ethoxycarbonylglycinate 
• 13756-47-3 N-(ethoxycarbonyl)-α-amino methyl carboxylic ester 
• 140-88-5 ethyl acrylate 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 14891-08-8 N-ethoxycarbonyl-N-ethoxycarbonylmethyl-β-alanine ethyl ester 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 130482-73-4 5-(3-Benzyloxy-propyl)-4-oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester 
• 130482-71-2 5-Benzyl-4-oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester 
• 130482-76-7 5-(Hydroxy-phenyl-methyl)-4-oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester 
• 1212-06-2 1-Ethoxycarbonyl-4-amino-Δ³-pyrrolin-3-carbonsaeure-ethylester 
• 142288-15-1 (2S,3R)-2-[(S)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-hydroxy-pyrrolidine-1-carboxylic acid ethyl ester 
• 142288-15-1 (2R,3S)-2-[(S)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-hydroxy-pyrrolidine-1-carboxylic acid ethyl ester 
• 142288-16-2 (4S,4aS,7aR)-4-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-[1,3]dioxino[5,4-b]pyrrole-5-carboxylic acid ethyl ester 
• 142288-16-2 (4S,4aR,7aS)-4-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-[1,3]dioxino[5,4-b]pyrrole-5-carboxylic acid ethyl ester 
• 142288-13-9 2-[(R)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 155975-26-1 (R)-2-[(S)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 142394-38-5 (S)-2-[(S)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 1046860-33-6 2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid isopropylamide 
• 1046860-32-5 2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyanomethylamide 
• 1046861-00-0 2-amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid ethylamide 

Relevant articles and documents

Method for preparing 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate

The invention provides a method for preparing 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate (I). The method comprises the steps: subjecting glycinate or an acceptable salt thereof (VIII), which serves as a raw material, to a reaction with chloroformate (VII), so as to produce an intermediate ethoxycarbonyl glycinate (VI); subjecting the intermediate (VI) to cyclization with acrylate (V) under alkaline conditions, so as to obtain a pyrrolidone intermediate (IV); and subjecting the intermediate (IV) to a reaction with 1,3-halochloropropane (III) so as to obtain an intermediate (II), and then,carrying out decarboxylation under acidic conditions, thereby obtaining the 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate (I). Compared with old processes, the method has the advantages that processing steps are shortened, processing operations are simplified, and the emission of waste gases, waste water and waste residues and the cost are greatly reduced, thereby being beneficial to industrialized enlarged production.

2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS

The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

A convergent total synthesis of mappicine ketone: A leading antiviral compound

An efficient total synthesis of the naturally occuring mappicine ketone 1 and mappicine 2 are described. The approach is based on the assembly of tricyclic amine 5 with pseudo acid chloride 20. A Friedlander condensation is utilized for the construction o