Welcome to LookChem.com Sign In|Join Free

Cas Database

27126-76-7

27126-76-7

Identification

  • Product Name:Iodine,hydroxy(4-methylbenzenesulfonato-kO)phenyl-

  • CAS Number: 27126-76-7

  • EINECS:-0

  • Molecular Weight:392.214

  • Molecular Formula: C13H13IO4S

  • HS Code:29039990

  • Mol File:27126-76-7.mol

Synonyms:Benzene,[hydroxy[(p-tolylsulfonyl)oxy]iodo]- (8CI);Iodine,hydroxy(4-methylbenzenesulfonato-O)phenyl-;Benzenesulfonic acid, 4-methyl-,iodine complex;HTIB;Hydroxy(4-methylbenzenesulfonato-O)phenyliodine;Hydroxy(4-methylbenzenesulfonato-kO)phenyliodine;Hydroxy(phenyl)iodo tosylate;Koser's reagent;NSC 294176;Phenyliodoso hydroxide tosylate;Phenyliodosyl hydroxide tosylate;Reagents,Koser's;[Hydroxy(4-toluenesulfonato)iodo]benzene;[Hydroxy(tosyloxy)iodo]benzene;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:[Hydroxy(tosyloxy)iodo]benzene
  • Packaging:250mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:[Hydroxy(tosyloxy)iodo]benzene >97.0%(T)
  • Packaging:5g
  • Price:$ 20
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:[Hydroxy(tosyloxy)iodo]benzene >97.0%(T)
  • Packaging:25g
  • Price:$ 81
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydroxy(tosyloxy)iodobenzene
  • Packaging:25 g
  • Price:$ 39
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydroxy(tosyloxy)iodobenzene
  • Packaging:500 g
  • Price:$ 458
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Hydroxy(tosyloxy)iodobenzene
  • Packaging:100 g
  • Price:$ 119
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:[Hydroxy(tosyloxy)iodo]benzene 96%
  • Packaging:25g
  • Price:$ 112
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:[Hydroxy(tosyloxy)iodo]benzene 96%
  • Packaging:5g
  • Price:$ 46.7
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Oakwood
  • Product Description:Hydroxy{[(4-methylphenyl)sulfonyl]oxy}phenyliodine(HTIB) 96%
  • Packaging:5g
  • Price:$ 10
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Oakwood
  • Product Description:Hydroxy{[(4-methylphenyl)sulfonyl]oxy}phenyliodine(HTIB) 96%
  • Packaging:1g
  • Price:$ 9
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 28 Articles be found

Koser et al.

, p. 3609 (1976)

-

Stang,P.J.,Surber,B.W.

, p. 1452 (1985)

-

Application of [hydroxy(tosyloxy)iodo]benzene in the wittig-ring expansion sequence for the synthesis of β-benzocycloalkenones from α-benzocycloalkenones

Justik, Michael W.,Koser, Gerald F.

, p. 217 - 225 (2005)

The conversion of α-benzocycloalkenones to homologous β-benzocycloalkenones containing six, seven and eight-membered rings is reported. This was accomplished via a Wittig olefination-oxidative rearrangement sequence using [hydroxy(tosyloxy)iodo]-benzene (HTIB) is the oxidant, that enables the synthesis of regioisomeric pairs of methyl-substituted β-benzocycloalkenones. The incorporation of carbon-13 at C-1 of the β-tetralone nucleus was also demonstrated. The Wittig-HTIB approach is a useful alternative to analogous sequences in which Tl(NO3) 3·3H2O or the Prevost combination (AgNO 3/I2) are employed in the oxidation step.

Use of hypervalent iodine reagents in visible light-promoted α-ketoacylations of sulfoximines with aryl alkynes

Wang, Chenyang,Ma, Ding,Tu, Yongliang,Bolm, Carsten

, p. 8937 - 8940 (2020)

In visible light, sulfoximidoyl-containing hypervalent iodine reagents react with aryl alkynes to give N-α-ketoacylated sulfoximines in good to high yields. The process is metal- and base-free, providing the diketonic products without the use of highly ox

Synthesis of Diverse Aryliodine(III) Reagents by Anodic Oxidation?

Zu, Bing,Ke, Jie,Guo, Yonghong,He, Chuan

supporting information, p. 627 - 632 (2021/02/12)

An anodic oxidation enabled synthesis of hypervalent iodine(III) reagents from aryl iodides is demonstrated. Under mild electrochemical conditions, a range of aryliodine(III) reagents including iodosylarenes, (difunctionaliodo)arenes, benziodoxoles and diaryliodonium salts can be efficiently synthesized and derivatized in good to excellent yields with high selectivity. As only electrons serve as the oxidation reagents, this method offers a more straightforward and sustainable manner avoiding the use of expensive or hazardous chemical oxidants.

SYNTHESIS OF HYPERVALENT IODINE REAGENTS WITH DIOXYGEN

-

Paragraph 0085-0086, (2019/01/15)

Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.

A trivalent hypervalent iodine compound using hypochlorite (by machine translation)

-

Paragraph 0064, (2020/02/14)

[A] used in the prior art organic salt, toxic chlorine gas, organic peroxides can be used without the novel trivalent hypervalent iodine compound production. Furthermore, the acyloxy groups other than the trivalent hypervalent iodine compounds having a ligand manufacturing method. (1) Formula [solution](In the formula, R1 Substituted/unsubstituted aromatic group, aliphatic group or the like. N is an integer of 1 or more. ) Represented by the iodine compound, carboxylic acid, carboxylic acid anhydride, a sulfonic acid or sulfonic acid anhydride with at least one organic acid selected from the group consisting of, a hypochlorite mixing, trivalent hypervalent iodine compound. [Drawing] no (by machine translation)

Continuous-Flow Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications

Elsherbini, Mohamed,Winterson, Bethan,Alharbi, Haifa,Folgueiras-Amador, Ana A.,Génot, Célina,Wirth, Thomas

supporting information, p. 9811 - 9815 (2019/06/24)

An efficient and reliable electrochemical generator of hypervalent iodine reagents has been developed. In the anodic oxidation of iodoarenes to hypervalent iodine reagents under flow conditions, the use of electricity replaces hazardous and costly chemical oxidants. Unstable hypervalent iodine reagents can be prepared easily and coupled with different substrates to achieve oxidative transformations in high yields. The unstable, electrochemically generated reagents can also easily be transformed into classic bench-stable hypervalent iodine reagents through ligand exchange. The combination of electrochemical and flow-chemistry advantages largely improves the ecological footprint of the overall process compared to conventional approaches.

Process route upstream and downstream products

Process route

iodobenzene
591-50-4

iodobenzene

(hydroxy(tosyloxy)iodo)pentafluorobenzene
111873-52-0

(hydroxy(tosyloxy)iodo)pentafluorobenzene

1,2,3,4,5-pentafluoro-6-iodobenzene
827-15-6

1,2,3,4,5-pentafluoro-6-iodobenzene

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
In acetonitrile; for 24h; Ambient temperature;
[bis(acetoxy)iodo]benzene
3240-34-4

[bis(acetoxy)iodo]benzene

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
In acetonitrile;
100%
for 0.166667h;
97%
In acetonitrile; at 20 ℃;
94%
In acetonitrile; Heating;
93%
With toluene-4-sulfonic acid; In acetonitrile; for 0.5h;
88%
In acetonitrile;
87%
In acetonitrile;
82%
In acetonitrile; at 20 ℃; Inert atmosphere;
80%
In acetonitrile; at 20 ℃; for 0.5h;
80%
In acetonitrile; at 25 ℃; for 0.125h; Yield given;
In acetonitrile; at 20 ℃;
612 mg
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
benzene; With trifluorormethanesulfonic acid; iodine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.166667h;
toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h;
75%
phenylbis(2,2,2-trifluoroethoxy)- λ<sup>3</sup>-iodane

phenylbis(2,2,2-trifluoroethoxy)- λ3-iodane

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
In acetonitrile; at 20 ℃; Flow reactor;
80%
iodobenzene
591-50-4

iodobenzene

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hypochlorite pentahydrate / 0.17 h / 20 °C
2: acetonitrile / 20 °C
With sodium hypochlorite pentahydrate; In acetonitrile;
Multi-step reaction with 2 steps
1: tetrabutylammonium tetrafluoroborate / Electrolysis; Flow reactor
2: acetonitrile / 20 °C / Flow reactor
With tetrabutylammonium tetrafluoroborate; In acetonitrile;
Multi-step reaction with 2 steps
1: lithium perchlorate / 2,2,2-trifluoroethanol / 7.5 h / 20 °C / Electrochemical reaction
2: acetonitrile / 0.5 h / 20 °C
With lithium perchlorate; In 2,2,2-trifluoroethanol; acetonitrile;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

bis-[(trifluoroacetoxy)iodo]benzene
2712-78-9

bis-[(trifluoroacetoxy)iodo]benzene

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
for 0.166667h;
97%
<methoxy(tosyloxy)iodo>benzene
75067-08-2

benzene

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
With water; In acetonitrile;
83%
With water; In acetonitrile; Mechanism; also with methanol-d4 and further solvent;
μ-Oxo-I,I'-bis(trifluoroacetato-O)-I,I'-diphenyldiiodine(III)
91879-79-7

μ-Oxo-I,I'-bis(trifluoroacetato-O)-I,I'-diphenyldiiodine(III)

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
In chloroform; for 1h; Heating;
87%
iodosylbenzene
536-80-1

iodosylbenzene

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
In acetonitrile; at 20 ℃; for 0.0833333h;
iodobenzene
591-50-4

iodobenzene

[hydroxy(tosyloxy)iodo]benzene
27126-76-7

[hydroxy(tosyloxy)iodo]benzene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 92 percent / acetic acid / 4 h
2: 93 percent / acetonitrile / Heating
With acetic acid; In acetonitrile;

Global suppliers and manufacturers

Global( 105) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:79
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
  • Afine Chemicals Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-85134551
  • Emails:info@afinechem.com
  • Main Products:92
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 27126-76-7
Post Buying Request Now
close
Remarks: The blank with*must be completed