27825-20-3

Basic information

• Product Name: METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE
• Synonyms: METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE;Pyrazinecarboxylic acid, 3,4-dihydro-3-oxo-, methyl ester;Methyl 3-Hydroxy-2-pyrazinecarboxylate;methyl 2-oxo-1H-pyrazine-3-carboxylate
• CAS NO: 27825-20-3
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• Product Categories: pharmacetical
• Mol File: 27825-20-3.mol

Chemical Properties

• Melting Point: 154 °C
• Boiling Point: 417.9 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 1.41E-07mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 10.55±0.40(Predicted)
• CAS DataBase Reference: METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE(27825-20-3)
• EPA Substance Registry System: METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE(27825-20-3)

Safety Data

• Hazardous Substances Data: 27825-20-3(Hazardous Substances Data)

Usage

Uses

Used in Food and Beverage Industry:
METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE is used as a flavoring agent for its characteristic earthy, nutty, and roasted coffee-like aroma, enhancing the taste and aroma of various food products such as snacks, sauces, and beverages.
Used in Perfume and Cosmetics Industry:
METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE is used as a fragrance ingredient in perfumes and cosmetics due to its pleasant scent, contributing to the overall sensory experience of these products.
It is crucial to adhere to safety regulations and guidelines when using METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE to ensure the protection of human health and the environment.

InChI:InChI=1/C6H6N2O3/c1-11-6(10)4-5(9)8-3-2-7-4/h2-3H,1H3,(H,8,9)

Upstream product

• 67-56-1 methanol 
• 20737-42-2 3-oxo-3,4-dihydropyrazine-2-carboxylic acid 
• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 20737-42-2 3-hydroxypyrazine-2-carboxylic acid 

Downstream Products

• 55321-99-8 3-oxo-3,4-dihydropyrazine-2-carboxamide 
• 655228-07-2 methyl 4-[(4aR,7S,8aS)-2-phenylhexahydropyrano[3,2-d][1,3]dioxan-7-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxylate 
• 655228-09-4 Methyl 4-[(4aR,7R,8S,8aS)-8-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxan-7-yl]-3-oxo-3,4-dihydro-2-pyrazinecarboxylate 
• 356782-76-8 methyl 4-{(2R, 3R, 4R, 5R)-3,4-bis(benzoyloxy)-5-[(benzoyloxy)methyl]tetrahydro-2-furanyl}-3-oxo-3,4-dihydro-2-pyrazinecarboxylate 
• 356782-72-4 methyl 3-oxo-4-{4-[(trityloxy)methyl]-2-cyclopenten-1-yl}-3,4-dihydro-2-pyrazinecarboxylate 
• 1204400-32-7 methyl 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydiropyrazine-2-carboxylate 
• 114698-43-0 methyl 4-methyl-3-oxo-3,4-dihydropyrazin-2-carboxylate 
• 120992-56-5 4-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylic acid 
• 188622-62-0 2-(2-fluoro-5-chlorobenzyl)pyrazine-3-carboxylic acid 
• 188622-55-1 3-(5-Chloro-2-fluoro-benzyl)-pyrazine-2-carboxylic acid methyl ester 
• 1025948-42-8 3-Benzyliminomethyleneamino-pyrazine-2-carboxylic acid methyl ester 
• 157731-15-2 3-Allyl-2-phenylamino-3H-pteridin-4-one 
• 157731-14-1 2-Allylamino-3-phenylpteridin-4(3H)-one 

Relevant articles and documents

NEW CHEMICAL COMPOUNDS

The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

HETEROCYCLIC CARBOXYLIC ACID AMIDES AS PDK1 INIHIBITORS

The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

1H - IMIDAZO [4, 5 - C] QUINOLINES

The present invention encompasses compounds of general formula (1), wherein the groups R1 to R7, Qa, Qb, L, n and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations containing such compounds and their use as medicaments.

Synthesis of 2′-C-methyl ribonucleoside analogues with modified heterocyclic base moieties

Recently, 2′-C-methyl nucleoside analogues have been reported to exhibit potent anti-hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2′-C-methyl ribonucleoside analogues. Copyright Taylor & Francis Group, LLC.

NEW CHEMICAL COMPOUNDS

The present invention encompasses compounds of general formula (1) wherein the units W, A, L, Q1 and QH are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties.

Synthesis of regioisomeric 6,9-(chlorofluoro)-substituted benzo[g]quinoline-5,10-diones, benzo[g]isoquinoline-5,10-diones and 6-chloro-9-fluorobenzo[g]quinoxaline-5,10-dione

Treatment of difluoro or chloro fluoro-substituted benzyl bromides 5a-c with zinc dust in tetrahydrofuran leads to the corresponding benzylic zinc bromides 6a-c. These organometallics on treatment with chlorosubstituted heterocyclic esters 4A and 4B mediated by nickel catalysis undergo couplings to yield dihalobenzyl substituted heterocyclic esters 7Aa-c and 7Ba-c. Treatment of 4c with 6c under Pd catalysis leads to 7Cc. The acids 8, prepared by hydrolysis of these esters, with treatment of fuming sulfuric acid undergo cyclizations and oxidations to yield the desired regioisomeric dihalo-substituted heterocyclic quinones 2.

Methyl 3-(triphenylphosphoranylideneamino)pyrazine-2-carboxylate: Synthesis, crystal structure and use in pteridin-4(3H)-ones synthesis

The title iminophosphorane 6 has been prepared from methyl 3-aminopyrazine-2-carboxylate 1 by a modified Kirsanov method using a triphenylphosphine-hexachloroethane-triethylamine system. The crystal structure of 6 illustrated an iminophosphorane function (N=P bond). 2,3-Disubstituted pteridin-4(3H)-ones were obtained in a one-pot reaction of 6 with isocyanates, followed by heterocyclization on addition of alcohols or amines.