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287714-35-6

287714-35-6

Identification

Synonyms:2-Chloropyrimidine-5-carboxylicacid methyl ester;Methyl 2-chloropyrimidine-5-carboxylate;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
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  • Manufacture/Brand:TRC
  • Product Description:Methyl2-Chloropyrimidine-5-carboxylate
  • Packaging:1g
  • Price:$ 155
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Methyl 2-chloropyrimidine-5-carboxylate 98%
  • Packaging:5 g
  • Price:$ 750
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Methyl 2-chloropyrimidine-5-carboxylate 98%
  • Packaging:1 g
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 2-chloropyrimidine-5-carboxylate 95+%
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 2-chloropyrimidine-5-carboxylate 95+%
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Methyl 2-chloropyrimidine-5-carboxylate 95+%
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  • Product Description:Methyl2-chloropyrimidine-5-carboxylate 98%
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  • Manufacture/Brand:Chemenu
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  • Manufacture/Brand:Chemenu
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  • Manufacture/Brand:Chemenu
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Relevant articles and documentsAll total 7 Articles be found

COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY

-

Paragraph 0088; 0095, (2020/04/09)

The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

-

Page/Page column 35, (2016/02/26)

The invention provides a compound of Formula I, Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.

HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES

-

Paragraph 0162; 0179, (2014/02/16)

The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The com-pounds can be used in methods of treating proliferative dis-eases and disorders such as cancer

Process route upstream and downstream products

Process route

2-amino-pyrimidine-5-carboxylic acid methyl ester
308348-93-8

2-amino-pyrimidine-5-carboxylic acid methyl ester

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

Conditions
Conditions Yield
2-amino-pyrimidine-5-carboxylic acid methyl ester; With hydrogenchloride; zinc(II) chloride; In dichloromethane; at 5 - 20 ℃; for 0.5h;
With sodium nitrite; at 5 - 10 ℃; for 2h;
44.4%
2-amino-pyrimidine-5-carboxylic acid methyl ester; With hydrogenchloride; zinc(II) chloride; In dichloromethane; water; at 15 - 20 ℃; for 0.5h; Cooling;
With sodium nitrite; In dichloromethane; water; at 5 - 10 ℃; for 2h;
44.4%
2-amino-pyrimidine-5-carboxylic acid methyl ester; With hydrogenchloride; zinc(II) chloride; In dichloromethane; water; at 15 - 20 ℃; for 0.5h;
With sodium nitrite; In dichloromethane; at 5 - 10 ℃; for 2h;
44.4%
2-amino-pyrimidine-5-carboxylic acid methyl ester; With hydrogenchloride; zinc(II) chloride; In dichloromethane; at 15 - 20 ℃; for 0.5h;
With sodium nitrite; In dichloromethane; at 5 - 10 ℃; for 2h;
44.4%
methanol
67-56-1

methanol

2-bromopyrimidine-5-carboxylic acid
374068-01-6

2-bromopyrimidine-5-carboxylic acid

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

Conditions
Conditions Yield
With diazomethyl-trimethyl-silane; In hexane; benzene; at 20 ℃; for 0.5h;
2-bromopyrimidine-5-carboxylic acid
374068-01-6

2-bromopyrimidine-5-carboxylic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

Conditions
Conditions Yield
In methanol; hexane; benzene; at 20 ℃; for 0.5h;
720 mg
2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

Conditions
Conditions Yield
1-Methylhomopiperazine
4318-37-0

1-Methylhomopiperazine

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

methyl 2-(4-methyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate
1035271-70-5

methyl 2-(4-methyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 25 ℃; for 18h;
94%
(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid
1186482-51-8

(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate
1204529-59-8

methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate

Conditions
Conditions Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 120 ℃; Inert atmosphere; Microwave;
58%
3-(3-methoxyphenyl)propan-1-amine
18655-52-2

3-(3-methoxyphenyl)propan-1-amine

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

2-[3-(3-methoxy-phenyl)propylamino]pyrimidine-5-carboxylic acid methyl ester
1400705-40-9

2-[3-(3-methoxy-phenyl)propylamino]pyrimidine-5-carboxylic acid methyl ester

Conditions
Conditions Yield
With potassium acetate; In methanol; at 150 ℃; for 1h; microwave irradiation;
99%
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(4-chloro-phenyl)
1407833-72-0

4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(4-chloro-phenyl)

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(methoxycarbonyl)pyrimidin-2-yl)-6-(4-chloro-phenyl)
1407833-76-4

4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(methoxycarbonyl)pyrimidin-2-yl)-6-(4-chloro-phenyl)

Conditions
Conditions Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; at 50 ℃; for 12h; Inert atmosphere;
39%
[7-tert-butyl-5-(4-chlorophenyl)furo[3,2-b]pyridin-2-yl]-(2,2-dimethylpiperazin-1-yl)methanone dihydrochloride

[7-tert-butyl-5-(4-chlorophenyl)furo[3,2-b]pyridin-2-yl]-(2,2-dimethylpiperazin-1-yl)methanone dihydrochloride

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

methyl 2-[4-[7-tert-butyl-5-(4-chlorophenyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazin-1-yl]pyrimidine-5-carboxylate

methyl 2-[4-[7-tert-butyl-5-(4-chlorophenyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazin-1-yl]pyrimidine-5-carboxylate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 120 ℃; for 0.166667h; Microwave irradiation;
89%
(3aR,5R,6aS)-5-(2-(trifluoromethyl)phenyl)octahydrocyclopenta[c]pyrrole hydrochloride

(3aR,5R,6aS)-5-(2-(trifluoromethyl)phenyl)octahydrocyclopenta[c]pyrrole hydrochloride

2-chloro-pyrimidine-5-carboxylic acid methyl ester
287714-35-6

2-chloro-pyrimidine-5-carboxylic acid methyl ester

methyl 2-((3aR,5r,6aS)-5-(2-(trifluoromethyl)phenyl)hexahydrocyclopenta[c]pyrrole-2(1H)-yl)pyrimidine-5-carboxylate

methyl 2-((3aR,5r,6aS)-5-(2-(trifluoromethyl)phenyl)hexahydrocyclopenta[c]pyrrole-2(1H)-yl)pyrimidine-5-carboxylate

Conditions
Conditions Yield
With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 16h;
52%
With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Inert atmosphere;

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