2987-46-4

Basic information

• Product Name: 4-AMINOPHENYL THIOCYANATE
• Synonyms: AKOS B029033;4-AMINOPHENYL THIOCYANATE;4-Thiocyanatoaniline;Thiocyanic acid, 4-aminophenyl ester (9CI);1-Amino-4-thiocyanatobenzene;4-Thiocyanobenzenamine;(4-azanylphenyl) thiocyanate;thiocyanic acid (4-aminophenyl) ester
• CAS NO: 2987-46-4
• Molecular Formula: C₇H₆N₂S
• Molecular Weight: 150.2
• EINECS: 233-118-8
• Product Categories: AMINEPRIMARY;API Intermediate
• Mol File: 2987-46-4.mol

Chemical Properties

• Melting Point: 142°C
• Boiling Point: 314.5°C at 760 mmHg
• Flash Point: 144°C
• Appearance: /
• Density: 1.2162 (rough estimate)
• Vapor Pressure: 0.000465mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• PKA: 2.94±0.10(Predicted)
• Water Solubility: 0.2g/L(temperature not stated)
• CAS DataBase Reference: 4-AMINOPHENYL THIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOPHENYL THIOCYANATE(2987-46-4)
• EPA Substance Registry System: 4-AMINOPHENYL THIOCYANATE(2987-46-4)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 2987-46-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Aminophenyl thiocyanate is used as a key intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Dye and Pigment Industry:
4-Aminophenyl thiocyanate is used as a precursor in the production of dyes and pigments, enabling the creation of a wide range of colors for various applications.
Used in Organic Synthesis for Research and Industrial Use:
4-Aminophenyl thiocyanate is used as a reagent in the synthesis of organic compounds for both research purposes and industrial applications, facilitating the development of new chemical products and processes.
Used in Chemical Reactions:
4-Aminophenyl thiocyanate is utilized for its ability to participate in a range of chemical reactions, making it an important component in organic synthesis and contributing to the advancement of chemical knowledge and technology.

InChI:InChI=1/C7H6N2S/c8-5-10-7-3-1-6(9)2-4-7/h1-4H,9H2

Upstream product

• 2137-92-0 4-nitrophenyl thiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 505-14-6 thiocyanogen 
• 62-53-3 aniline 
• 2959-01-5 N,N'-dichloro-urea 
• 333-20-0 potassium thioacyanate 
• 592-87-0 lead(II) thiocyanate 
• 15192-76-4 copper(II) thiocyanate 
• 28241-61-4 ammonia thiocyanic acid 
• 40897-45-8 m-Tolyl-p-aminophenyldisulfid 
• 151-50-8 potassium cyanide 
• 40897-46-9 m-Bromphenyl-p-aminophenyl-disulfid 
• 40897-47-0 4-(2-(4-bromophenyl)disulfanyl)benzenamine 
• 40897-48-1 4-aminophenyl 4'-nitrophenyl disulfide 

Downstream Products

• 29269-89-4 2-((4-thiocyanatophenyl)amino)ethan-1-ol 
• 99841-22-2 4-[N,N-bis(2-hydroxyethyl)amino]benzenethiocyanate 
• 23933-23-5 N,N'-(4-Thiocyanato-phenyl)-thioharnstoff 
• 98555-04-5 (4-thiocyanato-phenyl)-urea 
• 122148-91-8 4-cyanophenyl thiocyanate 
• 722-27-0 bis(4-aminophenyl)disulfide 
• 139-65-1 4,4'-thiobisaniline 
• 3774-52-5 4-thiocyanato-phenol 
• 3226-37-7 4-chlorophenyl thiocyanate 
• 3226-41-3 4-bromobenzenediazonium tetrafluoroborate 
• 3321-94-6 N-(4-thiocyanatophenyl)acetamide 
• 25733-03-3 1,4-dithiocyanatobenzene 
• 14030-87-6 2,6-dibromo-4-thiocyanato-aniline 
• 117043-04-6 (4-thiocyanato-phenyl)-arsonic acid 

Relevant articles and documents

Isoquinolinium-N-sulfonic acid thiocyanate/H2O2 as efficient reagent for thiocyanation of N-bearing (hetero)aromatic compounds

In the present study, isoquinoline sulfonic acid thiocyanate (isoquinoline-SO3H)SCN and isoquinoline sulfonic acid chloride (isoquinoline-SO3H)Cl as a novel and heterogeneous catalyst were designed and synthesized by a simple and ine

A two phase electrochemical method for thiocyanation

A two phase electrochemical method for thiocyanation has been described. Thiocyano derivatives of aromatic amines and phenols and isothiocyano derivatives of substituted amines were obtained in 50-80% yield.

A facile synthesis of aryl thiocyanates using sodium perborate

A simple and convenient synthesis of aryl thiocyanates in high yields using sodium perborate is described.

N-Thiocyanato-2,10-camphorsultam Derivatives: Design and Applications of Original Electrophilic Thiocyanating Reagents

The synthesis of bench-stable electrophilic thiocyanating reagents was depicted in two steps from readily available starting materials in good yields. These newly designed electrophilic reagents were successfully applied for the thiocyanation of different

Selective electrochemical: Para -thiocyanation of aromatic amines under metal-, oxidant- And exogenous-electrolyte-free conditions

An electrochemical oxidative para-C-H-thiocyanation of aromatic amines has been developed to construct thiocyanato aromatic compounds under metal-, oxidant-, and exogenous-electrolyte-free conditions in an undivided cell. The transformation is compatible

Porphyrin-Based Conjugated Microporous Polymer Tubes: Template-Free Synthesis and A Photocatalyst for Visible-Light-Driven Thiocyanation of Anilines

Conjugated microporous polymers (CMPs) represent an important type of functional materials. In this area, morphological engineering has remained a major challenge. Here, we report the synthesis of porphyrin-based CMP tubes (CMP-1) through a template-free

A highly effective green catalyst Ni/Cu bimetallic nanoparticles supported by dendritic ligand for chemoselective oxidation and reduction reaction

The highly active Ni/Cu bimetallic nanoparticles (NPs) of the different molar ratios of Ni and Cu (1:1, 1:3, 3:1) assisted by dendritic ligand 2,4,6-Tris (di-4-chlorobenzamido)-1,3-diazine were synthesized successfully confirmed by Scanning Electron Microscopy (SEM), Electron Diffraction X-ray (EDX), X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), and Transmission Electron Microscopy (TEM) analysis. These NPs were studied as a heterogeneous catalyst for the chemoselective oxidation of alcohol to the corresponding aldehyde at 30?min and chemoselective reduction of aromatic nitro substituents to the corresponding amino substituents at 20?min, while the Ni/Cu (3:1) NPs were found to be the most effective among other Ni/Cu?(1:1)?and Ni/Cu?(1:3)?NPs at room temperature under mild conditions. The Ni/Cu (3:1) NPs can be recycled for at least five successive runs with no perceptible decrease in catalytic activity. Graphic abstract: [Figure not available: see fulltext.]

ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light

An ARS-TiO2 photocatalyst has been prepared, by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark, to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazole, phenol, aniline, indole and pyrrole derivatives) were treated with the thiocyanate anion at room temperature. Herein, the first report on thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives under visible light is presented.

Visible-light-enabled regioselective aerobic oxidative C(sp2)-H thiocyanation of aromatic compounds by Eosin-Y photocatalyst

Herein, visible-light-enabled regioselective aerobic oxidative C(sp2)-H thiocyanation of aromatic compounds has been developed by employing eosin-Y as effective photocatalyst and oxygen as the green terminal oxidant. This process featured green, efficient and operationally simple. Furthermore, the practicality and utility of this protocol was demonstrated by the gram scale synthesis. Mechanistic studies suggested that this reaction was realized via a photoredox radical pathway.

Method for inducing thiocyanation of arylamine compound by visible light

The invention discloses a method for inducing thiocyanation of an arylamine compound by visible light. Specifically, in the atmosphere of oxygen or air, an arylamine compound, an ammonium thiocyanatecompound and copper chloride dihydrate are added into a