15192-76-4Relevant academic research and scientific papers
Development, evaluation and effect of anionic co-ligand on the biological activity of benzothiazole derived copper(II) complexes
Bandyopadhayaya, Shreetama,Bhar, Kishalay,Jain, Surbhi,Mandal, Chandi C.,Sharma, Anuj K.,Singh, Vikas K.,Tapryal, Suman
, (2020)
Research on development of novel metal based anti-cancer agents continues with its popularity among bioinorganic community. Benzothiazole, an important heterocyclic pharmacophore, was chosen as a valuable and useful scaffold for the synthesis of novel copper(II) complexes. Three new copper(II) complexes obtained from the synthesis of newly synthesized benzothiazole based N-(benzo[d]thiazol-2-ylmethyl)-N-methyl-2-(pyridin-2-yl)ethan-1-amine (btzpy) ligand with CuCl2 [Cu(btzpy)Cl2] (1), Cu(NCS)2 [Cu(btzpy)(NCS)2] (2), and Cu(NO3)2 [Cu(btzpy)(NO3)(H2O)]NO3 (3) were isolated and characterized by physical and spectroscopic measurements, including single-crystal X-ray structures. The interaction of complexes 1 and 3 with calf thymus (CT)-DNA was investigated using ethidium bromide fluorescence quenching assay and weak intercalation with KSV values of 9.8 × 102 M?1 and 8.2 × 102 M?1, respectively was observed. All three complexes have shown DNA cleavage of supercoiled plasmid DNA forming single nicked and double nicked forms in the presence of external reducing agents like 3-mercaptopropionic acid (3-MPA) and ascorbic acid. The water-soluble complexes 1 and 3 also show prominent hydrolytic DNA cleavage. From the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, it was observed that complex 2 also exhibits good antioxidant properties. The cytotoxicity of complexes 1–3 was tested against the lung cancer cell line (A549) and complex 2 with -NCS moiety shows maximum activity in the micromolar range. A rationale for the observed activity is proposed in light of the other properties of these molecules.
A Novel, Nonelectrochemical Synthesis of the Organic Superconductor κ-(BEDT-TTF)2Cu(NCS)2
Mueller, Harald,Ueba, Yoshinobu
, p. 32 - 39 (1993)
Bis(ethylendithio)tetrathiafulvalene (BEDT-TTF or ET) can be oxidized with Cu(SCN)2 to yield superconducting, microcrystalline κ-(ET)2CU(NCS)2.The reaction is achieved either by heating a suspension of the reactants in various organic solvents or by ultrasound agitation at room temperature.The formation of the title compound was established by X-ray diffractograms, FT-IR and ESR spectroscopy.Susceptibility measurements revealed superconducting transition temperatures of 9.5-10 K.The clearly observed Meissner effect suggests superconductivity to be a bulk property of the so-obtained powder samples.
SYNTHESIS AND STUDIES OF CuHg(NCX)4 (X=S, Se) AND THEIR COMPLEXES AND APPLICATION OF THE SOFTNESS PARAMETER IN THE ELUCIDATION OF THEIR STUCTURE
Singh, P. P.,Pal, R. B.,Srivastava, A. K.
, p. 303 - 316 (1980)
Complexes of CuHg(NCS)4, CuHg(NCS)2 (NCSe)2 and CuHg(NCSe)4 with tetrahydrofuran, dioxan, pyridine, 2-aminopyridine, nicotinamide, bipyridine and phenanthroline have been prepared and comparative studies made.Bipyridine and phenanthroline form cationic-an
Oxidation of phenyl propyne catalyzed by copper(II) complexes of a benzimidazolyl schiff base ligand: Effect of acid/base, oxidant, surfactant and morphology
Kumar, Ravinder,Mathur, Pavan
, p. 818 - 823 (2015)
Copper(II) complexes with a new N-Substituted benzimidazolyl schiff base ligand are used as catalyst for the oxidation of 1-phenyl propyne. The oxidation is carried out under mild conditions using stoichiometric amounts of oxidant and catalytic amounts of Cu(II) complex as catalyst. Effect of acid/base, oxidant, morphology and surfactant has been studied. Two major products of phenyl propyne oxidation are the α-diketonic product and a terminal aldehyde. Diketone is the major product under acidic conditions while aldehyde formation is highest under basic conditions. The maximum conversion is found with the NO3- bound complex. GC-MS is used to find the percentage yields of products. SEM and PXRD of the reused complexes as catalyst suggest that morphology affects the catalytic efficiency.
Copper(II) complexes of new tetradentate NSNO pyridylthioazophenol ligands: Synthesis, spectral characterization and crystal structure
Dhara, Pulak K.,Pramanik, Sadhan,Lu, Tian-Huay,Drew, Mike.G.B.,Chattopadhyay, Pabitra
, p. 2457 - 2464 (2004)
Copper(II) complexes of a series of new tetradentate NSNO ligands were synthesized and characterized spectroscopically. The ligands were also characterized by elemental analyses, IR, 1H NMR, FAB-MS and UV-Vis spectroscopy. The solid-state structures of two complexes 2a and 4a were established by X-ray crystallography. The geometry about the copper ion of the complexes is dependent on the counter anion of the copper salt used. The five-coordinated copper ion is distorted square pyramidal when SCN- or Cl- ligate with the copper(II) ion, occupying the equatorial position, whereas the geometry about the four-coordinated copper ion is square planar when the counter anion is perchlorate. The electronic spectra of 2 and 3 in methanol show that the distortion of square pyramidal towards trigonal bipyramidal geometry about the copper ion of the complexes in solution is dependent on the presence of the electron withdrawing group. All the complexes exhibit a band for S(σ) → Cu(II) charge transfer (LMCT) in the range of 380-394 nm. The EPR spectra of complexes 2 and 3 are consistent with the fact that the unpaired electron is predominantly in the dx2-y2 orbital as g II > gI. The redox behavior of all the complexes in methanol was studied by CV using TBAP as the supporting electrolyte.
Copper(II) complexes with box or flower type morphology: Sustainability versus perishability upon catalytic recycling
Kumar, Ravinder,Yadav, Anjana,Mahiya, Kuldeep,Mathur, Pavan
, p. 279 - 284 (2016)
Graphical abstract Selective oxidation of p-chlorobenzyl alcohol to p-chlorobenzaldehyde is carried out by new copper(II) complexes of a benzimidazolyl schiff base ligand. Efficiency of oxidation depends on the morphology of the complexes; box type morphology sustains catalysis upon recycling to a greater extent in comparison to the flower type.
Restraining the motion of a ligand for modulating the structural phase transition in two isomorphic polar coordination polymers
Wang, Bao-Ying,Xu, Wei-Jian,Xue, Wei,Lin, Rui-Biao,Du, Zi-Yi,Zhou, Dong-Dong,Zhang, Wei-Xiong,Chen, Xiao-Ming
, p. 9008 - 9011 (2014)
A structural phase transition induced by ligand motion was found in a new polar coordination polymer: [Cu(NCS)2(4-APy)2]n (4-APy = 4-aminopyridine). Restraining such motion in an isomorphic compound [Cu(NCS)2(4-MeAPy)2]n (4-MeAPy = 4-methylaminopyridine) results in distinct phase transition behaviour. These findings provide a new clue for modulating phase transition behaviour in known materials. the Partner Organisations 2014.
Synthesis and spectral studies of copper complexes using a N-octylated bis benzimidazole diamide ligand
Mohapatra, Subash Chandra,Mathur, Pavan
, p. 612 - 616 (2011)
Monomeric Cu(II) and Cu(I) complexes bound to a tetradentate bis-benzimidazole diamide ligand N,N′-bis(N-octyl benzimidazolyl-2yl) (methyl)pentane diamide (O-GBGA) have been isolated and characterized. X-Band EPR spectra of the copper(II) complexes in CH
Nitric oxide inhibition, antioxidant, and antitumour activities of novel copper(ii) bis-benzimidazole diamide nanocoordination complexes
Singla, Manisha,Ranjan, Rajeev,Mahiya, Kuldeep,Mohapatra, Subash C.,Ahmad, Sharif
, p. 4316 - 4327 (2015)
Novel copper(ii) nanocoordination complexes [LCuCl]Cl C1, [LCu(SCN)]SCN C2, and [LCu(NO3)]NO3C3 capped by bis-benzimidazole diamide ligand N1,N5-bis{(1H-benzo[d]imidazole-2-yl)methyl}glutarimide L were synthesized and characterized by spectroscopic methods viz. transmission electron microscopy (5-100 nm), dynamic light scattering, elemental analysis, EPR, and infrared spectroscopy. These complexes were also tested for their ability to inhibit nitric oxide release during culture. Lipopolysaccharide-induced superoxide production decreased most significantly for complex C2. Nanocoordination complex C2 also showed the most significant in vitro cytotoxicity against HeLa human cervical cancer cells, MCF-7 breast cancer cells, and U-87 glioblastoma cells, ranging from 50 μg ml-1 to 500 μg ml-1. In vivo study revealed an increase in body weight (11.5 g) for the tumour control groups, whereas in the case of the mouse groups treated with test sample C3, the difference in body weight as compared to the control was approximately 4.7 g. In further studies, it decreased to 2.2 g and 0.6 g in the case of mouse groups treated with nanocoordination complexes C1 and C2, respectively. The mean mouse survival time was 21 days, which increased to 100, 120, and 170 days for C3, C1, and C2, respectively.
Facile synthesis of a hierarchical CuS/CuSCN nanocomposite with advanced energy storage properties
Kannangara, Yasun Y.,Prabunathan, Pichaimani,Song, Jang-Kun
, p. 15387 - 15396 (2018/09/29)
We introduce CuS/CuSCN nanocomposites as active materials in pseudocapacitors, in which the redox reactions of both CuS and CuSCN simultaneously contribute to energy storage. This nanocomposite is prepared using an in situ methodology via facile, low-energy-consuming green nanochemistry. The CuS/CuSCN nanocomposites offer a high capacitance compared to their individual constituents. CuS nanorods (～15 nm) are anchored on the surface of CuSCN nanosheets (～100 nm) and they interconnect the CuSCN nanosheets, producing mesoporous nanoclusters with a large surface area, thus improving the charge transfer efficiency. The CuS/CuSCN nanocomposites exhibit high electrical conductivity and strong redox reactivity, and in particular, the pseudocapacitor with a compositional ratio of 1:1 exhibits the highest charge transfer efficiency. Consequently, the 11 CuS/CuSCN active material exhibits a high energy density (approximately 63 W h kg-1) and a high power density (1.9 kW kg-1 at 9.0 W h kg-1) as a single electrode. The highest specific capacitance is measured to be 1787.3 F g-1 in the single electrode. Furthermore, an aqueous asymmetric hybrid supercapacitor based on the CuS/CuSCN 1:1//activated carbon (AC) shows an approximately four times increase in the power density (7.9 kW kg-1), compared to the single electrode.
