29916-33-4

Basic information

• Product Name: 2-(2-furyl)-4,5-diphenyl-1H-imidazole
• Synonyms: 2-(2-furyl)-4,5-diphenyl-1H-imidazole
• CAS NO: 29916-33-4
• Molecular Formula: C₁₉H₁₄N₂O
• Molecular Weight: 286.32726
• Mol File: 29916-33-4.mol
• Article Data: 60

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-furyl)-4,5-diphenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-furyl)-4,5-diphenyl-1H-imidazole(29916-33-4)
• EPA Substance Registry System: 2-(2-furyl)-4,5-diphenyl-1H-imidazole(29916-33-4)

Safety Data

• Hazardous Substances Data: 29916-33-4(Hazardous Substances Data)

Usage

Type of compound

Synthetic chemical compound

Target enzyme

p38 mitogen-activated protein kinase (MAPK)

Mechanism of action

Inhibits the activity of p38 MAPK

Effects

Reduces production of inflammatory cytokines and other mediators involved in the pathogenesis of various diseases

Potential applications

Treatment of inflammatory conditions, cancer, and neurodegenerative disorders

Status

Extensively studied and subject of ongoing research and development

Properties

Novel, potent, and selective inhibitor of p38 MAPK

Upstream product

• 98-01-1 furfural 
• 631-61-8 ammonium acetate 
• 134-81-6 benzil 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 451-40-1 phenyl benzyl ketone 
• 24242-77-1 α-iodo-α-phenylacetophenone 
• 501-65-5 diphenyl acetylene 
• 54610-73-0 furan-5-carboxamidine 
• 1484-50-0 desyl bromide 

Downstream Products

• 141989-39-1 2-Furan-2-yl-1-methyl-4,5-diphenyl-1H-imidazole 

Relevant articles and documents

Catalytic conversion of 2,4,5-trisubstituted imidazole and 5-substituted 1H-tetrazole derivatives using a new series of half-sandwich (η6-p-cymene)Ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazone ligands

A new series of half-sandwich (η6-p-cymene) ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazide derivatives [Ru(η6-p-cymene)(Cl)(L)] [L = N'-(naphthalen-1-ylmethylene)thiophene-2-carbohydrazide (L1), N'-(anthracen-9-ylmethylene)thiophene-2-carbohydrazide (L2) and N'-(pyren-1-ylmethylene)thiophene-2-carbohydrazide (L3)] were synthesized. The ligand precursors and their Ru(II) complexes (1–3) were structurally characterized by spectral (IR, UV–Vis, NMR and mass spectrometry) and elemental analysis. The molecular structures of the ruthenium(II) complexes 1–3 were determined by single-crystal X-ray diffraction. All complexes were used as catalysts for the one-pot three-component syntheses of 2,4,5-trisubstitued imidazole and 5-substituted 1H-tetrazole derivatives. The catalytic studies optimized parameters as solvent, temperature and catalyst. The catalysts revealed very active for a broad range of aromatic aldehydes presenting either electron attractor or electron donor substituents and, although less active, moderate to high activities were observed for alkyl aldehydes.

A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions

A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields. (Figure presented.).

Sugar-Catalyzed Synthesis of Triarylimidazoles—An Exemplary Model of Sweet Chemistry

Abstract: A fine, green, and efficient method has been proposed for the synthesis of2-aryl-4,5-diphenyl-1H-imidazoles usingvarious sugars such as glucose, fructose, sucrose, lactose, and maltose ascatalysts. The syntheses were carried out under very mild