3060-46-6

Basic information

• Product Name: N-Methyl-L-leucine
• Synonyms: H-ALPHA-ME-LEU-OH;H-(ME)LEU-OH;ALPHA-METHYL-L-LEUCINE;N-METHYL-L-LEUCINE;N-ME-LEU-OH;N-ME-LEUCINE;N-ALPHA-METHYL-L-LEUCINE;L-N-Methylleucine
• CAS NO: 3060-46-6
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Product Categories: Amino Acid Derivatives;amino acid;amino acids;Pyrazoles,Pyrazines
• Mol File: 3060-46-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 300 °C
• Boiling Point: 226.1 °C at 760 mmHg
• Flash Point: 90.6 °C
• Appearance: /
• Density: 0.979 g/cm³
• Vapor Pressure: 0.0303mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: Store at RT.
• PKA: 2.48±0.21(Predicted)
• CAS DataBase Reference: N-Methyl-L-leucine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-L-leucine(3060-46-6)
• EPA Substance Registry System: N-Methyl-L-leucine(3060-46-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3060-46-6(Hazardous Substances Data)

Usage

General Description

N-Methyl-L-leucine is a chemical compound known for its use in biochemistry. As a derivative of the essential amino acid leucine, it is often used in scientific research related to protein synthesis and metabolism. It has a very specific structure that incorporates a methyl group, which refers to a carbon atom surrounded by three hydrogen atoms. This orientation allows N-Methyl-L-leucine to participate in various biochemical reactions. The safety profile and potential application of N-Methyl-L-leucine in medical or pharmaceutical contexts require further investigation, as with many such compounds used primarily in research settings.

InChI:InChI=1/C7H15NO2/c1-5(2)4-6(8-3)7(9)10/h5-6,8H,4H2,1-3H3,(H,9,10)/t6-/m0/s1

Upstream product

• 1342309-24-3 trichodepsipeptide B 
• 1342309-23-2 trichodepsipeptide A 
• 1242573-53-0 C₃₅H₅₁N₅O₆S 
• 1187486-26-5 carriebowmide sulfone 
• 10034-85-2 hydrogen iodide 
• 64143-96-0 N-methyl-N-tosyl-L-leucine 
• 7647-01-0 hydrogenchloride 
• 108027-39-0 Cyclosporin L 
• 1494680-68-0 ohmyungsamycin A 

Downstream Products

• 4104-44-3 N-methylisoamylamine 
• 879125-40-3 N-(1-acetyl-3-methyl-butyl)-N-methyl-acetamide 
• 69935-32-6 N-methyl-N-(2.4-dinitro-phenyl)-L-leucine 
• 13734-32-2 2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoic acid 
• 4216-95-9 p-Nitro-benzyloxycarbonyl-N-methyl-L-leucin 
• 141849-38-9 N-<2,3-bis(benzyloxy)benzoyl>-N-methyl-L-leucine 
• 816-66-0 4-methyl-2-oxopentanoic acid 
• 74-89-5 methylamine 
• 42417-80-1 Z-Ala-MeLeu-OH 
• 48168-99-6 N-methyl-L-leucine benzyl ester 
• 82414-76-4 valyl>-N-methylleucin-tert-butylester-chlorid 
• 84569-87-9 [2-((S)-1-{(S)-1-[((S)-1-Carboxy-3-methyl-butyl)-methyl-carbamoyl]-2-methyl-propylcarbamoyl}-ethoxycarbonyloxy)-ethyl]-triphenyl-phosphonium; chloride 
• 84569-85-7 [2-((S)-1-{(S)-1-[((S)-1-Carboxy-3-methyl-butyl)-methyl-carbamoyl]-2-methyl-propylcarbamoyl}-2-methyl-propoxycarbonyloxy)-ethyl]-triphenyl-phosphonium; chloride 
• 84569-83-5 lactoylvalyl>-N-methylleucin-tert-butylester-chlorid 

Relevant articles and documents

Adiponectin-Secretion-Promoting Cyclic Peptide-Polyketide Hybrids from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS0417

Three new cyclic peptide-polyketide hybrids (1-3) and two new chaetiacandin-type polyketides (4 and 5) along with nine known compounds were isolated from cultures of a halophyte-associated fungus, Colletotrichum gloeosporioides JS0417. Spectroscopic analysis revealed that 1-3 were cyclic depsipeptides where 3,5,11-trihydroxy-2,6-dimethyldodecanoic acid was linked to two amino acids through amide and ester bonds to form a 12-membered ring. Relative and absolute configurations for the peptides were determined with spectroscopic analysis and chemical reactions. The cyclic depsipeptides 2 and 6 were determined to act as strong adiponectin-secretion-promoting modulators with potential to treat metabolic diseases associated with hypoadiponectinemia. Notably, a known compound, tryptophol, significantly inhibited PGE2synthesis and also promoted adiponectin secretion, exhibiting a similar biological activity profile to aspirin, but with greater potency. The presence of an isoleucine moiety and non-glycosylation may be important for biological activity of the cyclic peptide-polyketide hybrids, and non-methoxylation of the side chain may influence activity of the indole derivatives.

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

CXCR7 plays an emerging role in several physiological processes. A linear peptide, amantamide (1), was isolated from marine cyanobacteria, and the structure was determined by NMR and mass spectrometry. The total synthesis was achieved by solid-phase method. After screening two biological target libraries, 1 was identified as a selective CXCR7 agonist. The selective activation of CXCR7 by 1 could provide the basis for developing CXCR7-targeted therapeutics and deciphering the role of CXCR7 in different diseases.

Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp. Marine Cyanobacterium

Janadolide, a new cyclic polyketide-peptide hybrid possessing a tert-butyl group, was isolated from an Okeania sp. marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configurations of the amino acid moieties were determined by acid hydrolysis and chiral-phase HPLC analyses. The absolute configuration of the two stereogenic centers in the polyketide moiety was elucidated based on a combination of degradation reactions and spectroscopic analyses including the phenyl-glycine methyl ester method. Janadolide showed potent antitrypanosomal activity with an IC50 value of 47 nM without cytotoxicity against human cells at 10 μM.