309735-44-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-[(phenylamino)methyl]-, 1,1-dimethylethyl ester
• Synonyms: 3-phenylaminomethylpiperidine-1-carboxylic acid tert-butyl ester;N-(1-Boc-piperidin-3-ylmethyl)aniline;N-(1-Boc-piperidin-3-ylmethyl)-aniline
• CAS NO: 309735-44-2
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Mol File: 309735-44-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[(phenylamino)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[(phenylamino)methyl]-, 1,1-dimethylethyl ester(309735-44-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[(phenylamino)methyl]-, 1,1-dimethylethyl ester(309735-44-2)

Safety Data

• Hazardous Substances Data: 309735-44-2(Hazardous Substances Data)

Usage

Type of compound

Synthetic organic compound, derivative of piperidinecarboxylic acid

Uses

Intermediate in the synthesis of pharmaceutical compounds, particularly in the production of angiotensin-converting enzyme (ACE) inhibitors, which are used in the treatment of hypertension and heart failure

Structure

1-Piperidinecarboxylic acid, 3-[(phenylamino)methyl]-, 1,1-dimethylethyl ester

Functional group

Tert-butyl ester, indicating a tert-butyl group attached to the carboxylic acid functional group

Stability

More stable and easier to handle in laboratory settings due to the presence of the tert-butyl group

Safety precautions

May be harmful if ingested or inhaled, and could be a skin and eye irritant, so it should be handled with caution.

Upstream product

• 62-53-3 aniline 
• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 149-73-5 trimethyl orthoformate 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 309735-80-6 N-(1-Boc-piperidin-3-ylmethyl)-N-phenyl-propionamide 
• 309748-82-1 furan-2-carboxylic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenyl amide 
• 1018480-10-8 C₁₂H₁₈N₂ 
• 116574-71-1 (±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate 
• 360555-24-4 N-(1-Boc-piperidin-3-yl-methyl)-N-phenyl-N'-ethylurea 
• 404589-50-0 3-[(methanesulfonyl-phenyl-amino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 309747-21-5 thiophene-2-carboxylic acid N-(1-Boc-piperidin-3-ylmethyl)-N-phenyl amide 

Relevant articles and documents

PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are useful for the treatment of diabetes and obesity.

Heterocyclic analgesic compounds and methods of use thereof

One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-coupled receptors, and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds as analgesics.

Antipsychotic sulfonamide-heterocycles, and methods of use thereof

One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.