313340-08-8

Basic information

• Product Name: 3,5-Dichloro-6-ethylpyrazinecarboxamide
• Synonyms: 3,5-Dichloro-6-ethylpyrazinecarboxamide;3,5-Dichloro-6-ethylpyrazine-2-carboxaMide;3,5-Dichloro-6-ethyl-pyrazine-2-carboxylic acid amide;3,5-dichloro-6-ethyl-2-Pyrazinecarboxamide;2-Pyrazinecarboxamide, 3,5-dichloro-6-ethyl-
• CAS NO: 313340-08-8
• Molecular Formula: C₇H₇Cl₂N₃O
• Molecular Weight: 220.05598
• Product Categories: API
• Mol File: 313340-08-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 271.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.454±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.10±0.50(Predicted)
• CAS DataBase Reference: 3,5-Dichloro-6-ethylpyrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-6-ethylpyrazinecarboxamide(313340-08-8)
• EPA Substance Registry System: 3,5-Dichloro-6-ethylpyrazinecarboxamide(313340-08-8)

Safety Data

• Hazardous Substances Data: 313340-08-8(Hazardous Substances Data)

Usage

Uses

3,5-Dichloro-6-ethyl-2-pyrazinecarboxamide acts as a reagent in the preparation of nitrogen-containing heterocyclic derivatives as remedies for complications of diabetes.

Upstream product

• 1254055-46-3 3,5-dichloro-6-ethylpyrazine-2-carbonitrile 
• 1314936-02-1 3,5-dichloro-2-ethylpyrazine 
• 77287-34-4 formamide 
• 312736-50-8 3,5-dichloropyrazine-2-carboxamide 
• 313339-92-3 3,5-dichloro-pyrazine-2-carbonitrile 

Downstream Products

• 1254049-66-5 6-ethyl-5-[(1-methylpiperidin-3-yl)amino]-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide 
• 1254048-03-7 5-{[(1-aminocyclohexyl)methyl]amino}-6-ethyl-3-{[3-(methylsulfonyl)phenyl]amino}pyrazine-2-carboxamide 
• 1254055-46-3 3,5-dichloro-6-ethylpyrazine-2-carbonitrile 

Relevant articles and documents

Preparation method of Gilteritinib key intermediate

The invention relates to the field of drug synthesis, and particularly discloses a preparation method of a Gilteritinib key intermediate, namely a method for synthesizing a 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I). The method is novel in route, simple and convenient to operate, high in yield, good in safety and suitable for industrial production, and comprises the following steps: by taking ethyl propionyl acetate as an initial raw material, carrying out hydrolytic acylation to obtain a compound III; carrying out ring closing on the compound III and aminomalononitrilep-toluenesulfonate to obtain a compound V; then carrying out amino diazotization chlorination to obtain a compound VI; carrying out phosphorus oxychloride transposition on the compound VI to obtain 3,5-dichloro-6-ethylpyrazine-2-carbonitrile (a compound VII); and hydrolyzing the compound VII to obtain the 3,5-dichloro-6-ethylpyrazinecarboxamide intermediate (compound I).