31582-29-3Relevant articles and documents
Pyridine Nucleus Hydroxylation with Copper Oxygenase Models
Reglier, Marius,Amadei, Edith,Tadayoni, Rahim,Waegell, Bernard
, p. 447 - 450 (1989)
Reaction of iodosylbenzene with CuI complexes (2a,b) occurs with hydroxylation in the ortho position of one pyridine nucleus; CuIII=O species are postulated.
Benzylic ligand hydroxylation starting from a dicopper μ- I·2:I·2 peroxo intermediate: Dramatic acceleration of the reaction by hydrogen-atom donors
Rolff, Malte,Hamann, Jessica Nadine,Tuczek, Felix
supporting information; experimental part, p. 6924 - 6927 (2011/08/06)
Radicals in directed pathways: The μ-I·2: I·2 peroxo CuII2 intermediate 1 shows a much faster benzylic ligand hydroxylation than systems without phenol. This novel reactivity can be further accelerated by addition of external H-atom donors such as TEMPO-H. The results imply initial H-atom transfer leading to the formation of phenoxyl radicals. A highly reactive copper oxyl intermediate is then formed, which inserts oxygen into the benzylic C-H bond. Copyright