32529-80-9

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester
• CAS NO: 32529-80-9
• Molecular Formula: C9H13ClO3
• Molecular Weight: 204.653
• Mol File: 32529-80-9.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester(32529-80-9)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-(chlorocarbonyl)-, methyl ester(32529-80-9)

Safety Data

• Hazardous Substances Data: 32529-80-9(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 619-82-9 trans-hexahydroterephthalic acid 
• 3399-22-2 dimethyl 1,4-cyclohexanedicarboxylate 
• 32529-79-6 4-(methoxycarbonyl)cyclohexanecarboxylic acid 

Downstream Products

• 114116-10-8 methyl 4-(4-n-butylbenzoyl)-cyclohexanoate 
• 183996-83-0 N-[trans-4-(2-hydroxy-1-methylethyl)cyclohexanecarbonyl]-D-phenylalanine 
• 183996-95-4 4-Isopropenyl-cyclohexanecarboxylic acid methyl ester 
• 134955-99-0 4-Isopropenyl-cyclohexanecarboxylic acid 

Relevant articles and documents

Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides

A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening

Based on fragment-based virtual screening and bioisoterism strategies, novel indazole and pyrazolo[3,4-b] pyridine derivatives as HDACs inhibitors were designed, synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds 15k and 15m were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds 15k and 15m showed better anti-proliferative activities against HCT-116 and HeLa cells than positive control SAHA. The western blot analysis results indicated that compounds 15k and 15m noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds 15k and 15m could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the molecular docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs.